<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Rheumatoid arthritis (RA) is an autoimmune systemic inflammatory disease, characterized by chronic synovial inflammation and destruction of cartilage and bone, results in varying degrees of deformity and functional disability. Previous research has shown that there is a link between adipokines and RA, but also other systemic diseases such as cardiovascular disease and diabetes mellitus. Adipokines are biologically active substances, which are predominantly or exclusively secreted from adipocytes of adipose tissue, or other adipose tissue cells such as: preadipocytes, immune cells infiltrated in AT, or other cell types within this tissue. These molecules play a significant role in energy homeostasis and metabolism regulation, and are also involved in chronic inflammation and metabolic dysfunctions. Some of the adipokines act like hormones in glucose homeostasis and appetite regulation, while others, like cytokines, support the link between obesity and insulin resistance with the immune system and the inflammatory process. However, the clear role of adipokines in pathological conditions has not yet been established. This review will focus on current knowledge about the role of the two most prominent adipokines, leptin and adiponectin, in the pathogenesis of RA.</p>
</abstract>

Rheumatoid arthritis (RA) is an autoimmune systemic inflammatory disease, characterized by chronic synovial inflammation and destruction of cartilage and bone, results in varying degrees of deformity and functional disability. Previous research has shown that there is a link between adipokines and RA, but also other systemic diseases such as cardiovascular disease and diabetes mellitus. Adipokines are biologically active substances, which are predominantly or exclusively secreted from adipocytes of adipose tissue, or other adipose tissue cells such as: preadipocytes, immune cells infiltrated in AT, or other cell types within this tissue. These molecules play a significant role in energy homeostasis and metabolism regulation, and are also involved in chronic inflammation and metabolic dysfunctions. Some of the adipokines act like hormones in glucose homeostasis and appetite regulation, while others, like cytokines, support the link between obesity and insulin resistance with the immune system and the inflammatory process. However, the clear role of adipokines in pathological conditions has not yet been established. This review will focus on current knowledge about the role of the two most prominent adipokines, leptin and adiponectin, in the pathogenesis of RA.

The Role of Leptin and Adiponectin in Rheumatoid Arthritis

University of Kragujevac, Faculty of Medical Sciences

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"The Role of Leptin and Adiponectin in Rheumatoid Arthritis"}

Rheumatoid arthritis (RA) is an autoimmune systemic inflammatory disease, characterized by chronic synovial inflammation and destruction of cartilage and bone,...

The Role of Leptin and Adiponectin in Rheumatoid Arthritis

Publié en ligne: 01 févr. 2023

Pages: -

Reçu: 02 nov. 2021

Accepté: 20 nov. 2021

DOI: https://doi.org/10.2478/sjecr-2021-0055

Mots clés
Rheumatoid arthritis, adipokines, leptin, adiponectin

© 2021 Stefan Mikic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The Role of Leptin and Adiponectin in Rheumatoid Arthritis

Publié en ligne: 01 févr. 2023

Pages: -

Reçu: 02 nov. 2021

Accepté: 20 nov. 2021

DOI: https://doi.org/10.2478/sjecr-2021-0055

Mots clésRheumatoid arthritis, adipokines, leptin, adiponectin

© 2021 Stefan Mikic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
Rheumatoid arthritis, adipokines, leptin, adiponectin