Nanoplastics as a Potential Environmental Health Factor: From Molecular Interaction to Altered Cellular Function and Human Diseases

1. Plastics Europe. Plastics - the facts 2018: an analysis of European plastics production, demand and waste data [Internet]. 2018. Available from: https://www.plasticseurope.org/download_file/force/2387/319Search in Google Scholar

2. Heidbreder LM, Bablok I, Drews S, Menzel C. Tackling the plastic problem: A review on perceptions, behaviors, and interventions. Sci Total Environ. 2019;668:1077–93.10.1016/j.scitotenv.2019.02.43731018449Search in Google Scholar

3. Andreani G, Cannavacciuolo A, Menotta S, Spallucci V, Fedrizzi G, Carpenè E, et al. Environmental exposure to non-essential trace elements in two bat species from urbanised (Tadarida teniotis) and open land (Miniopterus schreibersii) areas in Italy. Environ Pollut. 2019;254(Pt B):113034.10.1016/j.envpol.2019.11303431465904Search in Google Scholar

4. Vanapalli KR, Sharma HB, Ranjan VP, Samal B, Bhattacharya J, Dubey BK, et al. Challenges and strategies for effective plastic waste management during and post COVID-19 pandemic. Sci Total Environ. 2020;750(1):141514.10.1016/j.scitotenv.2020.141514Search in Google Scholar

5. Bläsing M, Amelung W. Plastics in soil: Analytical methods and possible sources. Sci Total Environ. 2018;612(1):422–35.10.1016/j.scitotenv.2017.08.08628863373Search in Google Scholar

6. Horton AA, Walton A, Spurgeon DJ, Lahive E, Svendsen C. Microplastics in freshwater and terrestrial environments: Evaluating the current understanding to identify the knowledge gaps and future research priorities. Sci Total Environ. 2017;586(1):127–41.10.1016/j.scitotenv.2017.01.19028169032Search in Google Scholar

7. Shen M, Zhang Y, Zhu Y, Song B, Zeng G, Hu D, et al. Recent advances in toxicological research of nanoplastics in the environment: A review. Environ Pollut. 2019;252(Pt A):511–21.10.1016/j.envpol.2019.05.10231167159Search in Google Scholar

8. Kik K, Bukowska B, Sicińska P. Polystyrene nanoparticles: Sources, occurrence in the environment, distribution in tissues, accumulation and toxicity to various organisms. Environ Pollut. 2020;262(1):114297.10.1016/j.envpol.2020.11429732155552Search in Google Scholar

9. Lee WS, Cho H-J, Kim E, Huh YH, Kim H-J, Kim B, et al. Correction: Bioaccumulation of polystyrene nanoplastics and their effect on the toxicity of Au ions in zebrafish embryos. Nanoscale. 2019;11(7):3396.10.1039/C8NR90280A30608099Search in Google Scholar

10. Loos C, Syrovets T, Musyanovych A, Mailänder V, Landfester K, Nienhaus GU, et al. Functionalized polystyrene nanoparticles as a platform for studying bio-nano interactions. Beilstein J Nanotechnol. 2014;5:2403–12.10.3762/bjnano.5.250431171725671136Search in Google Scholar

11. van Midwoud PM, Janse A, Merema MT, Groothuis GMM, Verpoorte E. Comparison of biocompatibility and adsorption properties of different plastics for advanced microfluidic cell and tissue culture models. Anal Chem. 2012;84(9):3938–44.10.1021/ac300771z22444457Search in Google Scholar

12. Bojic S, Falco MM, Stojkovic P, Ljujic B, Gazdic Jankovic M, Armstrong L, et al. Platform to study intracellular polystyrene nanoplastic pollution and clinical outcomes. Stem Cells. 2020. [published online ahead of print]. doi:10.1002/stem.324410.1002/stem.324432614127Search in Google Scholar

13. Xu M, Halimu G, Zhang Q, Song Y, Fu X, Li Y, et al. Internalization and toxicity: A preliminary study of effects of nanoplastic particles on human lung epithelial cell. Sci Total Environ. 2019;694:133794.10.1016/j.scitotenv.2019.13379431756791Search in Google Scholar

14. Allen S, Allen D, Phoenix VR, Le Roux G, Durántez Jiménez P, Simonneau A, et al. Atmospheric transport and deposition of microplastics in a remote mountain catchment. Nat Geosci. 2019;12(5):339–44.10.1038/s41561-019-0335-5Search in Google Scholar

15. Lehner R, Weder C, Petri-Fink A, Rothen-Rutishauser B. Emergence of Nanoplastic in the Environment and Possible Impact on Human Health. Environ Sci Technol. 2019;53(4):1748–65.10.1021/acs.est.8b0551230629421Search in Google Scholar

16. Da Costa JP, Nunes AR, Santos PSM, Girão A V, Duarte AC, Rocha-Santos T. Degradation of polyethylene microplastics in seawater: Insights into the environmental degradation of polymers. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2018;53(9):866–75.10.1080/10934529.2018.145538129624466Search in Google Scholar

17. Bouwmeester H, Hollman PCH, Peters RJB. Potential Health Impact of Environmentally Released Micro- and Nanoplastics in the Human Food Production Chain: Experiences from Nanotoxicology. Environ Sci Technol. 2015;49(15):8932–47.10.1021/acs.est.5b0109026130306Search in Google Scholar

18. Ritz S, Schöttler S, Kotman N, Baier G, Musyanovych A, Kuharev J, et al. Protein corona of nanoparticles: distinct proteins regulate the cellular uptake. Biomacromolecules. 2015;16(4):1311–21.10.1021/acs.biomac.5b0010825794196Search in Google Scholar

19. Yang D, Shi H, Li L, Li J, Jabeen K, Kolandhasamy P. Microplastic Pollution in Table Salts from China. Environ Sci Technol. 2015;49(22):13622–7.10.1021/acs.est.5b0316326486565Search in Google Scholar

20. Grossi M, Morgunova M, Cheung S, Scholz D, Conroy E, Terrile M, et al. Lysosome triggered near-infrared fluorescence imaging of cellular trafficking processes in real time. Nat Commun. 2016;7(1):10855.10.1038/ncomms10855477351626927507Search in Google Scholar

21. Bhattacharjee S, Rietjens IMCM, Singh MP, Atkins TM, Purkait TK, Xu Z, et al. Cytotoxicity of surface-functionalized silicon and germanium nanoparticles: the dominant role of surface charges. Nanoscale. 2013;5(11):4870–83.10.1039/c3nr34266b366720823619571Search in Google Scholar

22. Terman A, Kurz T, Navratil M, Arriaga EA, Brunk UT. Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging. Antioxid Redox Signal. 2010;12(4):503–35.10.1089/ars.2009.2598286154519650712Search in Google Scholar

23. Rodolfo C, Campello S, Cecconi F. Mitophagy in neurodegenerative diseases. Neurochem Int. 2018;117:156–66.10.1016/j.neuint.2017.08.00428797885Search in Google Scholar

24. Galluzzi L, Kepp O, Kroemer G. Enlightening the impact of immunogenic cell death in photodynamic cancer therapy. EMBO J. 2012;31(5):1055–7.10.1038/emboj.2012.2329800622252132Search in Google Scholar

25. Ding F, Li Y, Liu J, Liu L, Yu W, Wang Z, et al. Overendocytosis of gold nanoparticles increases autophagy and apoptosis in hypoxic human renal proximal tubular cells. Int J Nanomedicine. 2014;9(1):4317–30.10.2147/IJN.S68685416886925246788Search in Google Scholar

26. Afeseh Ngwa H, Kanthasamy A, Gu Y, Fang N, Anantharam V, Kanthasamy AG. Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells. Toxicol Appl Pharmacol. 2011;256(3):227–40.10.1016/j.taap.2011.07.018320524021856324Search in Google Scholar

27. Brun E, Barreau F, Veronesi G, Fayard B, Sorieul S, Chanéac C, et al. Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia. Part Fibre Toxicol. 2014;11(1):13.10.1186/1743-8977-11-13398710624666995Search in Google Scholar

28. Jatana S, Callahan L, Pentland A, DeLouise L. Impact of Cosmetic Lotions on Nanoparticle Penetration through ex Vivo C57BL/6 Hairless Mouse and Human Skin: A Comparison Study. Cosmetics. 2016;3(1):6.10.3390/cosmetics3010006495578127453793Search in Google Scholar

29. Lane ME. Skin penetration enhancers. Int J Pharm. 2013;447(1–2):12–21.10.1016/j.ijpharm.2013.02.04023462366Search in Google Scholar

30. Prietl B, Meindl C, Roblegg E, Pieber TR, Lanzer G, Fröhlich E. Nano-sized and micro-sized polystyrene particles affect phagocyte function. Cell Biol Toxicol. 2014;30(1):1–16.10.1007/s10565-013-9265-y443421424292270Search in Google Scholar

31. Hwang J, Choi D, Han S, Choi J, Hong J. An assessment of the toxicity of polypropylene microplastics in human derived cells. Sci Total Environ. 2019;684:657–69.10.1016/j.scitotenv.2019.05.07131158627Search in Google Scholar

32. Yong CQY, Valiyaveetill S, Tang BL. Toxicity of Microplastics and Nanoplastics in Mammalian Systems. Int J Environ Res Public Health. 2020;17(5):1509.10.3390/ijerph17051509708455132111046Search in Google Scholar

33. Tanzi RE, Bertram L. Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective. Cell. 2005;120(4):545–55.10.1016/j.cell.2005.02.00815734686Search in Google Scholar