<abstract xmlns="http://www.w3.org/1999/xhtml">

Renal diseases have been documented as one of the massive health challenges, ranked as the 12th most common cause of death globally. This study was carried out to assess the chemopreventive effects of Vernonia amydalina on nitrobenzene mediated renal damage in rats. Rats were exposed to 100 mg/kg body weight of nitrobenzene via oral administration and treated with 200 mg/kg body weight (BW) and 400 mg/kg BW of methanol leaf extract of Vernonia amydalina (MLVA) and Vitamin E for 14 consecutive days. Nitrobenzene significantly induced a renal injury with a significant increase in the serum levels of urea and creatinine with the concomitant altered serum electrolyte profile. Also, nitrobenzene mediated the oxidative stress and lipid peroxidation with a significant increase in the renal level of malondialdehyde (MDA), hydrogen peroxide (H2O2), with a concomitant decrease in the level of reduced glutathione (GSH), Catalase (CAT) and Superoxide dismutase (SOD). Furthermore, an inflammation was observed in the nitrobenzene-treated rats with the elevated level of nitric oxide (NO) and myeloperoxidase (MPO). However, the treatment with methanol leaf extract of Vernonia amydalina reversed all the nitrobenzene-associated renal damage, electrolyte imbalance, oxidative stress, lipid peroxidation, inflammation and altered antioxidant defence system. Taken together, methanol leaf extract of Vernonia amydalina offers protection which may be beneficial for the treatment and management of kidney diseases or other related disorders via enhancing the serum electrolyte homeostasis, protecting the structural integrity of the kidney, antioxidant, anti-inflammatory mechanisms.
</abstract>

Renal diseases have been documented as one of the massive health challenges, ranked as the 12th most common cause of death globally. This study was carried out to assess the chemopreventive effects of Vernonia amydalina on nitrobenzene mediated renal damage in rats. Rats were exposed to 100 mg/kg body weight of nitrobenzene via oral administration and treated with 200 mg/kg body weight (BW) and 400 mg/kg BW of methanol leaf extract of Vernonia amydalina (MLVA) and Vitamin E for 14 consecutive days. Nitrobenzene significantly induced a renal injury with a significant increase in the serum levels of urea and creatinine with the concomitant altered serum electrolyte profile. Also, nitrobenzene mediated the oxidative stress and lipid peroxidation with a significant increase in the renal level of malondialdehyde (MDA), hydrogen peroxide (H2O2), with a concomitant decrease in the level of reduced glutathione (GSH), Catalase (CAT) and Superoxide dismutase (SOD). Furthermore, an inflammation was observed in the nitrobenzene-treated rats with the elevated level of nitric oxide (NO) and myeloperoxidase (MPO). However, the treatment with methanol leaf extract of Vernonia amydalina reversed all the nitrobenzene-associated renal damage, electrolyte imbalance, oxidative stress, lipid peroxidation, inflammation and altered antioxidant defence system. Taken together, methanol leaf extract of Vernonia amydalina offers protection which may be beneficial for the treatment and management of kidney diseases or other related disorders via enhancing the serum electrolyte homeostasis, protecting the structural integrity of the kidney, antioxidant, anti-inflammatory mechanisms.

Bitter Leaf (Vernonia Amygdalina) Modulates Nitrobenzene-Induced Renal Damage in Rats Via Suppression of Oxido-Inflammatory Activities

Department of Chemical Sciences, Faculty of Science

Phytomedicine and Toxicology Laboratories

Department of Biochemistry, Faculty of Basic and Applied Sciences

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Renal diseases have been documented as one of the massive health challenges, ranked as the 12th most common cause of death globally. This study was carried out...

Bitter Leaf (Vernonia Amygdalina) Modulates Nitrobenzene-Induced Renal Damage in Rats Via Suppression of Oxido-Inflammatory Activities

Publié en ligne: 02 févr. 2022

Pages: 317 - 324

Reçu: 03 avr. 2020

Accepté: 11 juil. 2020

DOI: https://doi.org/10.2478/sjecr-2020-0040

Mots clés
Renal damage, Nitrobenzene, oxidative stress, Vernonia amydalina, Inflammation, Electrolyte imbalance

© 2021 Johnson Olaleye Oladele et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Bitter Leaf (Vernonia Amygdalina) Modulates Nitrobenzene-Induced Renal Damage in Rats Via Suppression of Oxido-Inflammatory Activities

Publié en ligne: 02 févr. 2022

Pages: 317 - 324

Reçu: 03 avr. 2020

Accepté: 11 juil. 2020

DOI: https://doi.org/10.2478/sjecr-2020-0040

Mots clésRenal damage, Nitrobenzene, oxidative stress, Vernonia amydalina, Inflammation, Electrolyte imbalance

© 2021 Johnson Olaleye Oladele et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
Renal damage, Nitrobenzene, oxidative stress, Vernonia amydalina, Inflammation, Electrolyte imbalance