<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Antipsychotic drugs are commonly prescribed for different mental disorders and can be classified into two main groups: the first which contain originally developed antipsychotics of the first generation or typical antipsychotics and the other group with newly developed antipsychotics or atypical antipsychotics of the second generation. In this study, eleven antipsychotic drugs (chlorpromazine, flupentixol, haloperidol, zuclopenthixol, aripiprazole, clozapine, olanzapine, quetiapine, risperidone, sertindole, ziprasidone) were investigated to evaluate significance of their molecular physicochemical properties (lipophilicity, aqueous solubility, polar surface area, molecular weight, volume value and acidity) for their bioavailability. Relationships between literature available intestinal absorption data of antipsychotic drugs and their lipophilicity descriptor with one additional molecular descriptor, investigated using multiple linear regression analysis provided high correlations for molecular descriptors, Mw, Vol, pKa, as additional independent variables. Values of correlation coefficients (R<sup>2</sup>) were ranged from 0.951 (for Vol) above 0.944 (for Mw) to 0.923 (for pKa).</p>
</abstract>

Antipsychotic drugs are commonly prescribed for different mental disorders and can be classified into two main groups: the first which contain originally developed antipsychotics of the first generation or typical antipsychotics and the other group with newly developed antipsychotics or atypical antipsychotics of the second generation. In this study, eleven antipsychotic drugs (chlorpromazine, flupentixol, haloperidol, zuclopenthixol, aripiprazole, clozapine, olanzapine, quetiapine, risperidone, sertindole, ziprasidone) were investigated to evaluate significance of their molecular physicochemical properties (lipophilicity, aqueous solubility, polar surface area, molecular weight, volume value and acidity) for their bioavailability. Relationships between literature available intestinal absorption data of antipsychotic drugs and their lipophilicity descriptor with one additional molecular descriptor, investigated using multiple linear regression analysis provided high correlations for molecular descriptors, Mw, Vol, pKa, as additional independent variables. Values of correlation coefficients (R2) were ranged from 0.951 (for Vol) above 0.944 (for Mw) to 0.923 (for pKa).

A Study of Absorption and Selected Molecular Physicochemical Properties of Some Antipsychotic Drugs

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Antipsychotic drugs are commonly prescribed for different mental disorders and can be classified into two main groups: the first which contain originally...

A Study of Absorption and Selected Molecular Physicochemical Properties of Some Antipsychotic Drugs

Publié en ligne: 14 oct. 2022

Pages: -

Reçu: 08 janv. 2020

Accepté: 06 févr. 2020

DOI: https://doi.org/10.2478/sjecr-2020-0004

Mots clés
Antipsychotic drugs, absorption, lipophilicity, solubility, polar surface area

© 2020 Jadranka Odovic, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

A Study of Absorption and Selected Molecular Physicochemical Properties of Some Antipsychotic Drugs

Publié en ligne: 14 oct. 2022

Pages: -

Reçu: 08 janv. 2020

Accepté: 06 févr. 2020

DOI: https://doi.org/10.2478/sjecr-2020-0004

Mots clésAntipsychotic drugs, absorption, lipophilicity, solubility, polar surface area

© 2020 Jadranka Odovic, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
Antipsychotic drugs, absorption, lipophilicity, solubility, polar surface area