<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The earliest therapy use of gold compounds dated in 2500 AD. In 1960s gold compounds were used in the treatment of rheumatoid arthritis, discoid lupus erythematosus, etc. Although the compounds of Au(I) are well-known and used in the modern medicine, new complexes of Au(III) and ligands with different donor atoms are synthetized and examined for their biological (antitumor, antimicrobial) activity. So far conducted studies show that complexes with Au(III) as central metal ions have greater activity compared with free ligands. Future syntheses should be based on the increase of biological activity with complexes that have necessary stability under physiological conditions.</p></abstract>

The earliest therapy use of gold compounds dated in 2500 AD. In 1960s gold compounds were used in the treatment of rheumatoid arthritis, discoid lupus erythematosus, etc. Although the compounds of Au(I) are well-known and used in the modern medicine, new complexes of Au(III) and ligands with different donor atoms are synthetized and examined for their biological (antitumor, antimicrobial) activity. So far conducted studies show that complexes with Au(III) as central metal ions have greater activity compared with free ligands. Future syntheses should be based on the increase of biological activity with complexes that have necessary stability under physiological conditions.

Biological Activity of Au(III) Complexes

the Faculty of Medical Sciences, Department of Pharmacy

the Faculty of Science, Department of Chemistry

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Biological Activity of Au(III) Complexes"}

The earliest therapy use of gold compounds dated in 2500 AD. In 1960s gold compounds were used in the treatment of rheumatoid arthritis, discoid lupus...

Biological Activity of Au(III) Complexes

Publié en ligne: 29 nov. 2019

Pages: -

Reçu: 14 juin 2019

Accepté: 14 juin 2019

DOI: https://doi.org/10.2478/sjecr-2019-0050

Mots clés
gold(I)-complexes, gold(III)-complexes, antitumor activity, antimicrobial activity, gold nanoparticles

© 2019 Ana S. Stankovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Biological Activity of Au(III) Complexes

Publié en ligne: 29 nov. 2019

Pages: -

Reçu: 14 juin 2019

Accepté: 14 juin 2019

DOI: https://doi.org/10.2478/sjecr-2019-0050

Mots clésgold(I)-complexes, gold(III)-complexes, antitumor activity, antimicrobial activity, gold nanoparticles

© 2019 Ana S. Stankovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
gold(I)-complexes, gold(III)-complexes, antitumor activity, antimicrobial activity, gold nanoparticles