<abstract xmlns="http://www.w3.org/1999/xhtml">

The aim of our research was to increase the effectiveness of the therapy administered to the patients with idiopathic mitral valve prolapse by pharmacological correction of magnesium deficiency. 79 patients (23 females and 56 males with average years of age 35.7±4.3 ) with undifferentiated connective tissue dysplasia and mitral valve prolapse of the 1st and 2nd degree were examined. The control group consisted of 20 healthy individuals, comparable by sex and age. A test by the UNESCO Institute for Microelements was used for the preliminary diagnostics of magnesium deficiency. Daily ECG monitoring with heart rate variability analysis, echodopplercardiography with the assessment of left ventricular diastolic function and determination of magnesium concentration in blood serum were performed. For the demonstration of autonomic dysfunction “the test for detection of the signs of vegetative changes” was used (10). For the assessment of situational and personal anxiety an “anxiety test” by Ch. D. Spielberg and Y. L. Hanin (25, 26) was used. The succeeding study was performed after 6 months. It was found that complex therapy with magnesium orotate in patients with idiopathic mitral valve prolapse helps to reduce the frequency of clinical manifestations of neurovegetative disturbances in the majority of examined patients contributing to harmonization of the autonomic nervous system function. It has a favorable effect on dysplastic changes and the state of bioelectrical activity of the heart, as well as correction of the psychoemotional state.
</abstract>

The aim of our research was to increase the effectiveness of the therapy administered to the patients with idiopathic mitral valve prolapse by pharmacological correction of magnesium deficiency. 79 patients (23 females and 56 males with average years of age 35.7±4.3 ) with undifferentiated connective tissue dysplasia and mitral valve prolapse of the 1st and 2nd degree were examined. The control group consisted of 20 healthy individuals, comparable by sex and age. A test by the UNESCO Institute for Microelements was used for the preliminary diagnostics of magnesium deficiency. Daily ECG monitoring with heart rate variability analysis, echodopplercardiography with the assessment of left ventricular diastolic function and determination of magnesium concentration in blood serum were performed. For the demonstration of autonomic dysfunction “the test for detection of the signs of vegetative changes” was used (10). For the assessment of situational and personal anxiety an “anxiety test” by Ch. D. Spielberg and Y. L. Hanin (25, 26) was used. The succeeding study was performed after 6 months. It was found that complex therapy with magnesium orotate in patients with idiopathic mitral valve prolapse helps to reduce the frequency of clinical manifestations of neurovegetative disturbances in the majority of examined patients contributing to harmonization of the autonomic nervous system function. It has a favorable effect on dysplastic changes and the state of bioelectrical activity of the heart, as well as correction of the psychoemotional state.

Magnesium in Idiopathic Mitral Valve Prolapse

State Institution “National Institute of Therapy named after L.T. Malaya of the National Academy of Medical Sciences of Ukraine”

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Magnesium in Idiopathic Mitral Valve Prolapse"}

The aim of our research was to increase the effectiveness of the therapy administered to the patients with idiopathic mitral valve prolapse by pharmacological...

Magnesium in Idiopathic Mitral Valve Prolapse

Publié en ligne: 05 août 2021

Pages: 107 - 115

Reçu: 15 mai 2019

Accepté: 04 juin 2019

DOI: https://doi.org/10.2478/sjecr-2019-0026

Mots clés
valvular disease, magnesium deficiency, treatment

© 2021 Oleksandr Bilovol et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Magnesium in Idiopathic Mitral Valve Prolapse

Publié en ligne: 05 août 2021

Pages: 107 - 115

Reçu: 15 mai 2019

Accepté: 04 juin 2019

DOI: https://doi.org/10.2478/sjecr-2019-0026

Mots clésvalvular disease, magnesium deficiency, treatment

© 2021 Oleksandr Bilovol et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
valvular disease, magnesium deficiency, treatment