<abstract xmlns="http://www.w3.org/1999/xhtml">Colorectal cancer (CRC) represents one of the most common cancers. It is frequently diagnosed at advanced stages, indicating on need for new diagnostic markers. The aim of this study was to determine systemic and fecal values of IL-17 and IL-33 in patients with CRC and the relationship with clinicopathological aspects of disease.The blood samples and feces liquid fraction of 50 patients with CRC were analyzed. Serum and fecal levels of IL-33 and IL-17 were measured using sensitive enzyme-linked immunosorbent assay (ELISA) kits.Fecal levels of Il-33 and IL-17 were increased in CRC patients with poor tumor tissue differentiation. Serum IL-33 and fecal IL-17 were increased in patients with presence of lung/liver metastasis or peritoneal carcinomatosis, respectively, while enhanced fecal IL-33 was detected only in patients with peritoneal carcinomatosis.Positive correlation between IL-33 and IL-17 values in sera and feces, respectively was also observed.We believe that increased local values of IL-33 and IL-17, reflected trough higher fecal concentration, in CRC patients with poor tumor tissue differentiation and with presence of lung/liver metastasis or peritoneal carcinomatosis may be considered as a sign of the tumor’s malignant progression and, consequently, of a poor prognosis for patients.</abstract>

Colorectal cancer (CRC) represents one of the most common cancers. It is frequently diagnosed at advanced stages, indicating on need for new diagnostic markers. The aim of this study was to determine systemic and fecal values of IL-17 and IL-33 in patients with CRC and the relationship with clinicopathological aspects of disease.The blood samples and feces liquid fraction of 50 patients with CRC were analyzed. Serum and fecal levels of IL-33 and IL-17 were measured using sensitive enzyme-linked immunosorbent assay (ELISA) kits.Fecal levels of Il-33 and IL-17 were increased in CRC patients with poor tumor tissue differentiation. Serum IL-33 and fecal IL-17 were increased in patients with presence of lung/liver metastasis or peritoneal carcinomatosis, respectively, while enhanced fecal IL-33 was detected only in patients with peritoneal carcinomatosis.Positive correlation between IL-33 and IL-17 values in sera and feces, respectively was also observed.We believe that increased local values of IL-33 and IL-17, reflected trough higher fecal concentration, in CRC patients with poor tumor tissue differentiation and with presence of lung/liver metastasis or peritoneal carcinomatosis may be considered as a sign of the tumor’s malignant progression and, consequently, of a poor prognosis for patients.

Increased IL-33 and IL-17 in Colorectal Carcinoma Patients with Severe Disease

Faculty of Medicine Foca, Department of Surgery

Faculty of Medical Sciences, Department of Internal medicine

Department of Pharmacy, Faculty of Medical Sciences

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Increased IL-33 and IL-17 in Colorectal Carcinoma Patients with Severe Disease"}

Colorectal cancer (CRC) represents one of the most common cancers. It is frequently diagnosed at advanced stages, indicating on need for new diagnostic...

Increased IL-33 and IL-17 in Colorectal Carcinoma Patients with Severe Disease

Publié en ligne: 21 déc. 2020

Pages: 239 - 245

Reçu: 03 sept. 2018

Accepté: 05 sept. 2018

DOI: https://doi.org/10.2478/sjecr-2018-0034

Mots clés
Colorectal carcinoma, IL-17, IL-33

© 2020 Veljko Maric et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Increased IL-33 and IL-17 in Colorectal Carcinoma Patients with Severe Disease

Publié en ligne: 21 déc. 2020

Pages: 239 - 245

Reçu: 03 sept. 2018

Accepté: 05 sept. 2018

DOI: https://doi.org/10.2478/sjecr-2018-0034

Mots clésColorectal carcinoma, IL-17, IL-33

© 2020 Veljko Maric et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
Colorectal carcinoma, IL-17, IL-33