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Modulation of Epileptic Activity in Rats: Focus on Sleep, Physical Exercise and Nitric Oxide–mediated Neurotransmission in a Model of Homocysteine Thiolactone–induced Seizures

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1. Duncan JS, Sander JW, Sisodiya SM, Walker MC. Adult epilepsy. Lancet 2006; 367: 1087-100.10.1016/S0140-6736(06)68477-8Search in Google Scholar

2. Badawy RA, Harvey AS, Macdonell RA. Cortical hyperexcitability and epileptogenesis: understanding the mechanisms of epilepsy - part 1. J Clin Neurosci 2009; 16(3): 355-65.10.1016/j.jocn.2008.08.026Search in Google Scholar

3. Loscher W. Current status and future directions in the pharmacotherapy of epilepsy. Trends Pharmacol Sci 2002; 23, 113-118.10.1016/S0165-6147(00)01974-XSearch in Google Scholar

4. Stanojlović OP, Zivanović DP. Experimental models of epilepsy. Med Pregl 2004;57 (7-8):359-62.10.2298/MPNS0408359SSearch in Google Scholar

5. Hoffer LJ. Homocysteine remethylation and trans-sulfuration. Metabolism 2004; 53: 1480-3.10.1016/j.metabol.2004.06.00315536605Search in Google Scholar

6. Djuric D, Jakovljević V, Rašić-Marković A, Đurić A, Stanojlović A. Homocysteine, folic acid and coronary artery disease: possible impact on prognosis and therapy. Indian J Chest Di Allied Sci 2008;50: 39-48.Search in Google Scholar

7. Jakubowski H. Molecular basis of homocysteine toxicity in humans. Cell Mol Life Sci. 2004; 61: 470-87.10.1007/s00018-003-3204-714999406Search in Google Scholar

8. Perla-Kajan J, Twardowski T, Jakubowski H. Mechanisms of homocysteine toxicity in humans. Amino Acids 2007;32: 561-72.10.1007/s00726-006-0432-917285228Search in Google Scholar

9. Herrmann W, Obeid R. Homocysteine: a biomarker in neurodegenerative diseases. Clin Chem Lab Med 2011; 49: 435-41.10.1515/CCLM.2011.08421388339Search in Google Scholar

10. Troen AM. The central nervous system in animal models of hyperhomocysteinemia. Prog Neuropsychopharmacol Biol Psychiatry. 2005; 29:1140-51.10.1016/j.pnpbp.2005.06.02516111797Search in Google Scholar

11. Stanojlović O, Rašić-Marković A, Hrnčić D, et al. Two types of seizures in homocysteine thiolactone - treated adult rats, behavioral and encephalographic study. Cell Mol Neurobiol 2009; 29: 329-39.10.1007/s10571-008-9324-818972205Search in Google Scholar

12. Malow B. Sleep and epilepsy. Neurol Clin 1996; 14 (4): 765-89.10.1016/S0733-8619(05)70284-XSearch in Google Scholar

13. Matos G, Andersen ML, do Valle AC, Tufik S. The relationship between sleep and epilepsy: evidence from clinical trials and animal models. J Neurol Sci. 2010; 295(1-2): 1-7.10.1016/j.jns.2010.05.00320621798Search in Google Scholar

14. Hrnčić D, Rašić-Marković A, Bjekić-Macut J, et al. Gaseous neurotansmitter nitric oxide: its role in experimental models of epilepsy. Arch Biol Sci 2012; 64(3): 1207-16.10.2298/ABS1203207HSearch in Google Scholar

15. Sardo P, Carletti F, D’Agostino S, Rizzo V, Ferraro G. Involvement of nitric oxide-soluble guanylyl cyclase pathway in the control of maximal dentate gyrus activation in the rat. J Neural Transm. 2006; 113 (12): 1855-61.10.1007/s00702-006-0491-916736237Search in Google Scholar

16. Royes LF, Fighera MR, Furian AF, et al. Involvement of NO in the convulsive behavior and oxidative damage induced by the intrastriatal injection of methylmalonate. Neuroscience Letters 2005; 376: 116-20.10.1016/j.neulet.2004.11.03815698932Search in Google Scholar

17. Royes LF, Fighera MR, Furian AF, et al. The role of nitric oxide on the convulsive behavior and oxidative stress induced by methylmalonate: an electroencephalographic and neurochemical study. Epilepsy Res 2007; 73: 228-37.10.1016/j.eplepsyres.2006.10.00917137751Search in Google Scholar

18. Stanojlović O, Zivanović D, Mirković S, Mikhaleva I. Delta sleep-inducing peptide and its tetrapeptide analogue alleviate severity of metaphit seizures. Pharmacol Biochem Behav 2004: 77(2) 227-34.10.1016/j.pbb.2003.10.01414751449Search in Google Scholar

19. Stanojlović O, Hrnčić D, Živanović D, Šušić V. Anticonvulsant, but not antiepileptic action of valproate on audiogenic seizure in metaphit - treated rats. Clin Exp Pharmacol Physiol 2007; 34: 1010-5.10.1111/j.1440-1681.2007.04681.x17714087Search in Google Scholar

20. Hrnčić D, Stanojlović O, Živanović D, Šušić V. Delta sleep - inducing peptide potentiates anticonvulsive activity of valproate against metaphit - provoked audiogenic seizures in rats. Pharmacol. 2006; 77: 78-84.10.1159/00009300116645330Search in Google Scholar

21. Hrnčić D, Vučević D, Rašić A, et al. Moderate body hypothermia alleviates behavioral and EEG manifestations of audiogenic seizures in metaphit - treated rats. Canad J Physiol Pharmacol 2007; 85: 1032-37.10.1139/Y07-09418066104Search in Google Scholar

22. Vučević D, Hrnčić D, Radosavljević T, et al. Correlation between electrocorticographic and motor phenomena in lindane-induced experimental epilepsy in rats. Canad J Physiol Pharmacol. 2008; 86: 173-9.10.1139/Y08-010Search in Google Scholar

23. Mladenović D, Hrnčić D, Vučević D, et al. Ethanol suppresed seizures in lindane- treated rats. Electroencephalographic and behavioral studies. J Physiol Pharmacol 2007; 58:641-54.Search in Google Scholar

24. Hrnčić D, Rašić-Marković A, Sušić V, Djurić D, Stanojlović O. Influence of NR2B-Selective NMDA Antagonist on Lindane-Induced Seizures in Rats. Pharmacol 2009; 84: 234-9.10.1159/000238055Search in Google Scholar

25. Rašić-Marković A, Djuric D, Hrnčić D, et al. High dose of ethanol decreases total spectral power density in seizures induced by D,L - homocysteine thiolactone in adult rats. Gen Physiol Bioph 2009; 28: 25-33.Search in Google Scholar

26. Rašić-Marković A, Hrnčić D, Djurić D, et al. The effect of N-methyl-D-aspartate receptor antagonists on D, L-homocysteine thiolactone induced seizures in adult rats. Acta Physiol Hung 2011; 98 (1): 17-26.10.1556/APhysiol.98.2011.1.3Search in Google Scholar

27. Rasić-Marković A, Stanojlović O, Hrnčić D, et al. The activity of erythrocyte and brain Na+/K+ and Mg2+- ATPases in rats subjected to acute homocysteine and homocysteine thiolactone administration.Mol Cell Biochem 2009; 327: 39-45.10.1007/s11010-009-0040-6Search in Google Scholar

28. Rašić-Marković A, Hrnčić D, Macut D, Stanojlović O, Djuric D. Anticonvulsive Effect of Folic Acid in Homocysteine Thiolactone-Induced Seizures. Cell Mol Neurobiol. 2011; 31 (8): 1221-28.10.1007/s10571-011-9724-zSearch in Google Scholar

29. Martins RC, Andersen ML, Tufik S. The reciprocal interaction between sleep and type 2 diabetes mellitus: facts and perspectives. Braz J Med Biol Res 2008;41:180-7.10.1590/S0100-879X2006005000194Search in Google Scholar

30. Stanojlović O, Hrnčić D, Rašić-Marković A, Macut Dj, Djurić D, Šušić V. Sleep peptides in experimental models of epilepsy. Glas Srp Akad Nauka Med.2011; (51): 141-9.Search in Google Scholar

31. Jouvet M. Paradoxical sleep as a programming system. J Sleep Res 1998; 7:1-5.10.1046/j.1365-2869.7.s1.1.xSearch in Google Scholar

32. Matos G, Tufik S, Scorza FA, Cavalheiro EA, Andersen ML. Sleep, epilepsy and translational research: what can we learn from the laboratory bench? Prog Neurobiol 2011; 95 (3): 396-405.Search in Google Scholar

33. Susic V, Markovic O. Potentiation of metaphite - induced audiogenic seizures by REM sleep deprivation in rats. Physiol Behav 1993; 54: 331-8.10.1016/0031-9384(93)90119-ZSearch in Google Scholar

34. Mendez M, Radtke RA. Interactions between sleep and epilepsy. J Clin Neurophysiol 2001; 18: 106-27.10.1097/00004691-200103000-0000311435803Search in Google Scholar

35. Crespel A, Baldy-Moulinier M, Coubes P. The relationship between sleep and epilepsy in frontal and temporal lobe epilepsies: practical and physiopathologic considerations. Epilepsia 1998; 39, 150-7.10.1111/j.1528-1157.1998.tb01352.x9577994Search in Google Scholar

36. Derry CP, Duncan S. Sleep and epilepsy. Epilepsy Behav 2013; 26 (3): 394-404.10.1016/j.yebeh.2012.10.033Search in Google Scholar

37. Mallick BN, Singh A. REM sleep loss increases brain excitability: role of noradrenaline and its mechanism of action. Sleep Med Rev 2011; 15: 165-78.10.1016/j.smrv.2010.11.001Search in Google Scholar

38. Jouvet D, Vilmont P, Delorme F, Jouvet M. Etude de la privation selective de la phase paradoxale de sommeil chez le chat. C R Soc Biol Fil 1964; 158: 756-9.Search in Google Scholar

39. Tufik S, Andersen ML, Bittencourt LR, Mello MT. Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research. An Acad Bras Cienc 2009; 81: 521-38.10.1590/S0001-37652009000300016Search in Google Scholar

40. Nunes JR GP, Tufik S, Nobrega JN. Decreased muscarinic receptor binding in rat brain after paradoxical sleep deprivation: an autoradiographic study. Brain Res 1994; 645: 247-52.10.1016/0006-8993(94)91658-6Search in Google Scholar

41. McCarley RW. Neurobiology of REM and NREM sleep. Sleep Med 2007; 8: 302-30.10.1016/j.sleep.2007.03.00517468046Search in Google Scholar

42. Tufik S, Troncone LRP, Braz S. Does REM sleep deprivation induce subsensitivity of presynaptic dopamine or postsynaptic acetylcholine receptors in the rat brain? Eur J Pharmacol 1987; 140: 215-19.Search in Google Scholar

43. Mohamed SH, Ezz HAS, Khadrawy AY, Noor AN. Neurochemical and electrophysiological changes induced by paradoxical sleep deprivation in rats. Behav Brain Res 2011; 225: 39-4610.1016/j.bbr.2011.06.01821729722Search in Google Scholar

44. Hrnčić D, Rašić-Marković A, Macut-Bjekic J, Šušić V, Djuric D, Stanojlović O. Paradoxical sleep deprivation potentiates epilepsy induced by homocysteine thiolactone in rats. Exp Biol Med 2013; 238 (1): 77-83.10.1258/ebm.2012.01215423479766Search in Google Scholar

45. Dubow JS, Kelly JP. Epilepsy in sports and recreation. Sports Med 2003; 33: 499-516.10.2165/00007256-200333070-0000312762826Search in Google Scholar

46. Ablah E, Haug A, Konda K, Tinius AM, Ram S, Sadler T, Liow K. Exercise and epilepsy: a survey of Midwest epilepsy patients. Epilepsy Behav 2009; 14: 162-66.10.1016/j.yebeh.2008.09.01918926931Search in Google Scholar

47. Elliott JO, Lu B, Moore JL, McAuley JW, Long L. Exercise, diet, health behaviors, and risk factors among persons with epilepsy based on the California Health Interview Survey, 2005. Epilepsy Behav. 2008; 13: 307-15.10.1016/j.yebeh.2008.04.00318490199Search in Google Scholar

48. Gordon KE, Dooley JM, Brna PM. Epilepsy and activity- A population based study. Epilepsia 2010; 51: 2254-59.10.1111/j.1528-1167.2010.02709.xSearch in Google Scholar

49. Wong J, Wirrell E. Physical activity in children/teens with epilepsy compared with that in their siblings without epilepsy. Epilepsia 2006; 47: 631-9.10.1111/j.1528-1167.2006.00478.xSearch in Google Scholar

50. Fountain NB, May AC. Epilepsy and athletics. Clin Sports Med 2003; 22: 605-16.10.1016/S0278-5919(02)00106-0Search in Google Scholar

51. Kuijer A. Epilepsy and exercise, electroencephalographical and biochemical studies. Advances in Epileptology: The 10th Epilepsy International Symposium. Raven Press, New York 1980; 543.Search in Google Scholar

52. Ogunyemi AO, Gomez MR, Klass DW. Seizures induced by exercise. Neurology 1988; 38: 633-4.10.1212/WNL.38.4.633Search in Google Scholar

53. Ramsden M, Berchtold NC, Patrick Kesslak J, Cotman CW, Pike CJ. Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion. Brain Res 2003; 971: 239-44. 10.1016/S0006-8993(03)02365-5Search in Google Scholar

54. Arida RM, Jesus VA, Cavalheiro EA. Effect of physical exercise on kindling development. Epilepsy 1998; 30: 127-132.10.1016/S0920-1211(97)00102-2Search in Google Scholar

55. Arida RM, Scorza FA, dos Santos NF, Peres CA, Cavalheiro EA. Effect of physical exercise on seizure occurrence in a model of temporal lobe epilepsy in rats. Epilepsy Res 1999; 37: 45-52.10.1016/S0920-1211(99)00032-7Search in Google Scholar

56. Souza MA, Oliveira MS, Furian AF, et al. Swimming training prevents pentylenetetrazol-induced inhibition of Na+, K+-ATPase activity, seizures, and oxidative stress. Epilepsia 2009; 50: 811-23.10.1111/j.1528-1167.2008.01908.xSearch in Google Scholar

57. Arida RM, Sanabria ER, da Silva AC, Faria LC, Scorza FA, Cavalheiro EA. Physical training reverts hippocampal electrophysiological changes in rats submitted to the pilocarpine model of epilepsy. Physiol Behav 2004: 83(1): 165-71.10.1016/S0031-9384(04)00338-5Search in Google Scholar

58. Eriksen HR, Ellertsen B, Gronningsaeter H, Nakken KO, Loyning Y, Ursin H. Physical exercise in women with intractable epilepsy. Epilepsia 1994; 35: 1256-64.10.1111/j.1528-1157.1994.tb01797.x7988519Search in Google Scholar

59. Nakken KO, Loyning A, Loyning T, Gloersen G, Larsson PG. Does physical exercise influence the occurrence of epileptiform EEG discharges in children? Epilepsia 1997; 38: 279-84.Search in Google Scholar

60. Contarteze RV, de Alencar Mota CS, et al. Exercise test and glucose homeostasis in rats treated with alloxan during the neonatal period or fed a high calorie diet. J Diabetes 2009; 1:65-72.10.1111/j.1753-0407.2008.00003.x20923522Search in Google Scholar

61. Hrncic D, Rasic-Markovic A, Lekovic J, et al. Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress. Int J Sports Med. 2013, in press.10.1055/s-0033-135716224227119Search in Google Scholar

62. Elfering SL, Sarkela TM, Giulivi C. Biochemistry of mitochondrial nitric-oxide synthase. J Biol Chem. 2002; 277: 38079-86.10.1074/jbc.M20525620012154090Search in Google Scholar

63. Knowles RG, Moncada S. Nitric oxide synthases in mammals. Biochem J 1994; 298: 249-58.10.1042/bj298024911379327510950Search in Google Scholar

64. Zhou L, Zhu D. Neuronal nitric oxide synthase: Structure, subcellular localization, regulation, and clinical implications. Niric Oxide 2009; 20: 223-30.10.1016/j.niox.2009.03.00119298861Search in Google Scholar

65. Gonzalez-Hernandez T, Garcia-Marin V, Perez-Delgado MM, Gonzalez-Gonzalez ML, Rancel-Torres N, Gonzalez-Feria L. Nitric oxide synthase expression in the cerebral cortex of patients with epilepsy. Epilepsia 2000; 41: 1259-68.10.1111/j.1528-1157.2000.tb04603.x11051120Search in Google Scholar

66. Murashima YL, Yoshii M, Suzuki J . Role of nitric oxide in the epileptogenesis of EL mice. Epilepsia 2000; 41: 195-99.10.1111/j.1528-1157.2000.tb01581.x10999544Search in Google Scholar

67. Pannu R, Singh I. Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms. Neurochemistry International 2006; 49: 170-82.10.1016/j.neuint.2006.04.01016765486Search in Google Scholar

68. Rondouin G, Bockaert J, Lerner-Natoli M. L-Nitroarginine, an inhibitor of NO synthase, dramatically worsens limbic epilepsy in rats. NeuroReport. 1993; 4: 1187-90.Search in Google Scholar

69. Rondouin G, Lerner-Natoli M, Manzoni O, Lafon-Cazal M, Bockaert J. A nitric oxide (NO) synthase inhibitor accelerates amygdala kindling. NeuroReport 1992; 3: 805-56.10.1097/00001756-199209000-000211384771Search in Google Scholar

70. Paul V, Ekambaram P. Effects of sodium nitroprusside, a nitric oxide donor, on γ-aminobutyric acid concentration in the brain and on picrotoxin-induced convulsions in combination with phenobarbitone in rats. Pharmacol Biochem Behav. 2005; 80: 363-70. 71 .Ayyildiz M, Yildirim M, Agar E. The involvement of nitric oxide in the anticonvulsant effects of alpha-tocopherol on penicillin-induced epileptiform activity in rats. Epilepsy Res 2007; 73: 166-72.10.1016/j.eplepsyres.2006.09.00717085015Search in Google Scholar

72. Tutka P, Barczyński B, Arent K, Mosiewicz J, Mroz T, Wielosz M. Different effects of nitric oxide synthase inhibitors on convulsions induced by nicotine in mice. Pharmacol Rep 2007; 59: 259-67.Search in Google Scholar

73. Urbanska EM, Drelewska E, Borowicz KK, Blaszczak P, Kleinrok Z, Czuczwar SJ. NG-nitro-L-arginine, a nitric oxide synthase inhibitor, and seizure susceptibility in four seizure models in mice. J Neural Transm 1996; 103: 1145-52.10.1007/BF01271199Search in Google Scholar

74. Proctor MR, Fornai F, Afshar JK, Gale K. The role of nitric oxide in focally-evoked limbic seizures. Neurosci 1997; 76: 1231-6.10.1016/S0306-4522(96)00390-9Search in Google Scholar

75. Lu W, Chen G, Cheng JS. NMDA antagonist displays anticonvulsant effect via NO synthesis inhibition penicillin treated rat hippocampal slices. Neuroreport 1998; 9: 4045-9.Search in Google Scholar

76. Borowicz KK, Luszczki J, Kleinrok Z, Czuczwar SJ. 7- Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetrazol- induced convulsions. J Neural Transm 2000; 107: 1117-26.10.1007/s00702007002511129101Search in Google Scholar

77. Sardo P, Carletti F, D’Agostino S, Rizzo V, Ferraro G. Involvement of nitric oxide-soluble guanylyl cyclase pathway in the control of maximal dentate gyrus activation in the rat. J Neural Transm 2006; 113 (12): 1855-61.10.1007/s00702-006-0491-916736237Search in Google Scholar

78. Hrnčić D, Rašić-Marković A, Krstić D, Macut D, Djuric D, Stanojlović O. The Role of Nitric Oxide in Homocysteine Thiolactone-Induced Seizures in Adult Rats. Cell Mol Neurobiol 2010;30:219-31.10.1007/s10571-009-9444-919714460Search in Google Scholar

79. Hrnčić D, Rašić-Marković A, Krstić D, et al. Inhibition of the neuronal nitric oxide synthase potentiates homocysteine thiolactone-induced seizures in adult rats. Med Chem 2012; 8(1): 59-64.10.2174/15734061279927857722420552Search in Google Scholar

80. Hrnčić D, Rašić-Marković A, Macut D, Sušic V, Djuric D, Stanojlovic O. Homocysteine thiolactone-induced seizures in adult rats are aggravated by inhibition of inducible nitric oxide synthase. Hum Exp Toxicol 2013, in press, on line first.10.1177/096032711349151023760255Search in Google Scholar

81. Luszczki JJ, Sacharuk A, Wojciechowska A, et al. 7-Nitroindazole enhances dose-dependently the anticonvulsant activities of conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model. Pharmacol Rep 2006; 58 (5), 660-71.Search in Google Scholar

82. Lesani A, Javadi-Paydar M, Khodadad TK, et al. Involvement of the nitric oxide pathway in the anticonvulsant effect of tramadol on pentylenetetrazole-induced seizures in mice. Epilepsy Behav 2010; 19(3), 290-5.10.1016/j.yebeh.2010.08.00620880756Search in Google Scholar

83. Adabi-Mohazab R, Javadi-Paydar M, Delfan B, Dehpour AR. Possible involvement of PPAR-gamma receptor and nitric oxide pathway in the anticonvulsant effect of acute pioglitazone on pentylenetetrazole-induced seizures in mice. Epilepsy Res 2012; 101 (1-2): 28-35. 10.1016/j.eplepsyres.2012.02.01522436324Search in Google Scholar

84. Bahremand A, Nasrabady SE, Ziai P, et al. Involvement of nitric oxide-cGMP pathway in the anticonvulsant effects of lithium chloride on PTZ-induced seizure in mice. Epilepsy Res 2010; 89(2-3): 295-302.10.1016/j.eplepsyres.2010.02.00120304610Search in Google Scholar

85. Lipton SA, Choi YB, Pan ZH, et al. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 1993; 364: 626-32.10.1038/364626a0Search in Google Scholar

86. Getting SJ, Segieth J, Ahmad S, Biggs CS, Whitton PS. Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo. Brain Res. 1996 22; 717 (1-2): 196-9.10.1016/0006-8993(96)00127-8Search in Google Scholar

87. Paul V, Ekambaram P. Effects of sodium nitroprusside, a nitric oxide donor, on γ-aminobutyric acid concentration in the brain and on picrotoxin-induced convulsions in combination with phenobarbitone in rats. Pharmacol Biochem Behav 2005; 8 0: 363-70.10.1016/j.pbb.2004.08.02215740777Search in Google Scholar

88. Ramakrishnan S, Sulochana KN, Lakshmi S, Selvi R, Angayarkanni N. Biochemistry of homocysteine in health and diseases. Ind J Biochem Biophys 2006; 43: 275-83.Search in Google Scholar

89. Rauhala P, Lin AM, Chiueh CC. Neuroprotection by S nitrosoglutathione of brain dopamine neurons from oxidative stress. FASEB J 1998; 12: 165-73. 10.1096/fasebj.12.2.1659472981Search in Google Scholar

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