<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Acute Generalized Exanthemataous Pustulosis (AGEP) is a rare acute pustular eruption that is mostly induced by drugs. Aside from cutaneous eruptions, systemic symptoms such as leukocytosis, neutrophilia, and internal organ involvement such as liver, kidney, respiratory system, and bone marrow, may occur, although uncommon. Liver involvement usually results in a two- or three-fold increase of liver enzymes and rarely exceeds that. Pyrazinamide is the first-line anti-tuberculosis drug that is potentially hepatotoxic, but rarely shows dermatologic manifestations. We report a rare case of AGEP with drug induced liver injury due to pyrazinamide in a young patient with tuberculosis.</p></abstract>

Acute Generalized Exanthemataous Pustulosis (AGEP) is a rare acute pustular eruption that is mostly induced by drugs. Aside from cutaneous eruptions, systemic symptoms such as leukocytosis, neutrophilia, and internal organ involvement such as liver, kidney, respiratory system, and bone marrow, may occur, although uncommon. Liver involvement usually results in a two- or three-fold increase of liver enzymes and rarely exceeds that. Pyrazinamide is the first-line anti-tuberculosis drug that is potentially hepatotoxic, but rarely shows dermatologic manifestations. We report a rare case of AGEP with drug induced liver injury due to pyrazinamide in a young patient with tuberculosis.

A Rare Case of Acute Generalized Exanthematous Pustulosis with Drug-Induced Liver Injury caused by Pyrazinamide

Departemen Ilmu Kesehatan Kulit dan Kelamin Universitas Hasanuddin Makassar

Rumah Sakit Wahidin Sudirohusodo Makassar, Rumah Sakit Pendidikan Universitas Hasanuddin Makassar

Serbian Journal of Dermatology and Venereology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Acute Generalized Exanthemataous Pustulosis (AGEP) is a rare acute pustular eruption that is mostly induced by drugs. Aside from cutaneous eruptions, systemic...

A Rare Case of Acute Generalized Exanthematous Pustulosis with Drug-Induced Liver Injury caused by Pyrazinamide

Publié en ligne: 23 oct. 2020

Pages: 54 - 58

Reçu: 24 déc. 2019

Accepté: 07 avr. 2020

DOI: https://doi.org/10.2478/sjdv-2020-0009

Mots clés
Acute Generalized Exanthematous Pustulosis, Pyrazinamide, Chemical and Drug Induced Liver Injury, Drug-Related Side Effects and Adverse Reactions, Aspartate Aminotransferases, Alanine Transaminase

© 2020 St. Nurul et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

A Rare Case of Acute Generalized Exanthematous Pustulosis with Drug-Induced Liver Injury caused by Pyrazinamide

Publié en ligne: 23 oct. 2020

Pages: 54 - 58

Reçu: 24 déc. 2019

Accepté: 07 avr. 2020

DOI: https://doi.org/10.2478/sjdv-2020-0009

Mots clésAcute Generalized Exanthematous Pustulosis, Pyrazinamide, Chemical and Drug Induced Liver Injury, Drug-Related Side Effects and Adverse Reactions, Aspartate Aminotransferases, Alanine Transaminase

© 2020 St. Nurul et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
Acute Generalized Exanthematous Pustulosis, Pyrazinamide, Chemical and Drug Induced Liver Injury, Drug-Related Side Effects and Adverse Reactions, Aspartate Aminotransferases, Alanine Transaminase