<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Concomitant occurrence of psoriasis and bullous pemphigoid was described in less than 100 cases in the literature. The co-occurrence affects the treatment approach of patients. We present a case of a 58-year-old man with psoriasis presenting with erythematous plaques, tense bullae, erosions and fever up to 39°C. Direct and indirect immunofluorescence and histopathological examination confirmed the diagnosis of bullous pemphigoid. In our case, bullous eruptions were successfully treated with oral methylprednisolone and dapsone, and psoriasis with narrowband ultraviolet B phototherapy and acitretin. </p><p>In conclusion, the etiopathogenesis of the coexistence of these two entities remains unknown, but it may be related to relatively high incidence of psoriasis and bullous pemphigoid, respectively. Both conditions are immunologically mediated and combined immunosuppressive regimens, directed at cellular and humoral immune responses, usually result in clinical improvement.</p></abstract>

Concomitant occurrence of psoriasis and bullous pemphigoid was described in less than 100 cases in the literature. The co-occurrence affects the treatment approach of patients. We present a case of a 58-year-old man with psoriasis presenting with erythematous plaques, tense bullae, erosions and fever up to 39°C. Direct and indirect immunofluorescence and histopathological examination confirmed the diagnosis of bullous pemphigoid. In our case, bullous eruptions were successfully treated with oral methylprednisolone and dapsone, and psoriasis with narrowband ultraviolet B phototherapy and acitretin. In conclusion, the etiopathogenesis of the coexistence of these two entities remains unknown, but it may be related to relatively high incidence of psoriasis and bullous pemphigoid, respectively. Both conditions are immunologically mediated and combined immunosuppressive regimens, directed at cellular and humoral immune responses, usually result in clinical improvement.

Concomitant Psoriasis and Bullous Pemphigoid – a Case Report / Udružena pojava psorijaze i buloznog pemfigoida – prikaz slučaja

Department of Dermatology, School of Medicine, Military Medical Academy, Belgrade, Serbia

Institute of Pathology and Forensic Medicine, School of Medicine, Military Medical Academy, Belgrade, Serbia

Serbian Journal of Dermatology and Venereology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Concomitant occurrence of psoriasis and bullous pemphigoid was described in less than 100 cases in the literature. The co-occurrence affects the treatment...

Concomitant Psoriasis and Bullous Pemphigoid – a Case Report / Udružena pojava psorijaze i buloznog pemfigoida – prikaz slučaja

Publié en ligne: 26 juil. 2014

Pages: 30 - 38

DOI: https://doi.org/10.2478/sjdv-2014-0003

Mots clés
Psoriasis, Pemphigoid, Bullous, Comorbidity, Fluorescent Antibody Technique, Immunosuppressive Agents, Ultraviolet Therapy

© 2014

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Concomitant Psoriasis and Bullous Pemphigoid – a Case Report / Udružena pojava psorijaze i buloznog pemfigoida – prikaz slučaja

Publié en ligne: 26 juil. 2014

Pages: 30 - 38

DOI: https://doi.org/10.2478/sjdv-2014-0003

Mots clésPsoriasis, Pemphigoid, Bullous, Comorbidity, Fluorescent Antibody Technique, Immunosuppressive Agents, Ultraviolet Therapy

© 2014

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
Psoriasis, Pemphigoid, Bullous, Comorbidity, Fluorescent Antibody Technique, Immunosuppressive Agents, Ultraviolet Therapy