<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Lagochilascaris minor is the causative agent of lagochilascariosis, a disease that affects the neck region causing exudative abscesses with eggs, adult parasites and L3/L4 larvae within purulent exudates. Nowadays, mice are considered intermediate hosts for the parasite. To determine the pattern of infection in B1 cell-defective mice, experimental lagochilascariosis was studied in BALB/c and X-chromosome-linked immunodeficient (Xid) mice. BALB.xid infected mice showed higher survival ratios and less intense lung lesions than BALB/c mice. Serum levels of IL-10 was higher in BALB/c infected mice when compared to BALB.xid animals; however, serum levels of IFNγ, in control and infected BALB.xid mice, were statistically different from that seen in BALB/c mice. We discuss the participation of B1 cells and their cytokines in the resistance to infection.</p></abstract>

Lagochilascaris minor is the causative agent of lagochilascariosis, a disease that affects the neck region causing exudative abscesses with eggs, adult parasites and L3/L4 larvae within purulent exudates. Nowadays, mice are considered intermediate hosts for the parasite. To determine the pattern of infection in B1 cell-defective mice, experimental lagochilascariosis was studied in BALB/c and X-chromosome-linked immunodeficient (Xid) mice. BALB.xid infected mice showed higher survival ratios and less intense lung lesions than BALB/c mice. Serum levels of IL-10 was higher in BALB/c infected mice when compared to BALB.xid animals; however, serum levels of IFNγ, in control and infected BALB.xid mice, were statistically different from that seen in BALB/c mice. We discuss the participation of B1 cells and their cytokines in the resistance to infection.

The X-chromosome-linked immunodeficiency determines an improved course of murine lagochilascariosis

Department of Microbiology, Immunology, Parasitology and Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil

Helminthologia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Lagochilascaris minor is the causative agent of lagochilascariosis, a disease that affects the neck region causing exudative abscesses with eggs, adult...

The X-chromosome-linked immunodeficiency determines an improved course of murine lagochilascariosis

Publié en ligne: 17 nov. 2009

Pages: 205 - 208

DOI: https://doi.org/10.2478/s11687-009-0038-3

Mots clés
B1 cells, BALB.xid mice, cytokine, Lagochilascaris minor, lagochilascariosis

© 2009 Institute of Parasitology, SAS, Košice, Slovakia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The X-chromosome-linked immunodeficiency determines an improved course of murine lagochilascariosis

Publié en ligne: 17 nov. 2009

Pages: 205 - 208

DOI: https://doi.org/10.2478/s11687-009-0038-3

Mots clésB1 cells, BALB.xid mice, cytokine, Lagochilascaris minor, lagochilascariosis

© 2009 Institute of Parasitology, SAS, Košice, Slovakia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
B1 cells, BALB.xid mice, cytokine, Lagochilascaris minor, lagochilascariosis