[1. van Hal SJ, Paterson DL. Systematic review and meta- analysis of the significance of heterogeneous vancomycin- intermediate Staphylococcus aureus isolates. Antimicrob Agents Chemother. 2011;55(1):405-10. DOI: 10.1128/AAC.01133-1010.1128/AAC.01133-10301965421078939]Search in Google Scholar
[2. Filleron A, Chironb R, Reverdyc ME, Jean-Pierred H, Dumitrescu O, et al. Staphylococcus aureus with decreased susceptibility to glycopeptides in cystic fibrosis patients. Journal of Cystic Fibrosis 2011;10(5):377-82. DOI: 10.1016/j.jcf.2011.05.00110.1016/j.jcf.2011.05.00121636331]Search in Google Scholar
[3. Garnier F, Chainier D, Walsh T, Karlsson A, Bolmström A, Grelaud C, et al. A 1 year surveillance study of glycopeptide-intermediate Staphylococcus aureus strains in a French hospital. J Antimicrob Chemother. 2006;57(1):146-9. DOI: 10.1093/jac/dki41310.1093/jac/dki41316286482]Search in Google Scholar
[4. Charles PG, Ward PB, Johnson DR, Howden BP, Grayson LM. Clinical features associated with bacteremia due to heterogeneous vancomycin-intermediate Staphylococcus aureus. Clin Infect Dis. 2004;38(3):448-51. DOI: 10.1086/38109310.1086/38109314727222]Search in Google Scholar
[5. Rong SL, Leonard SN. Heterogeneous vancomycin resistance in Staphylococcus aureus: a review of epidemiology, diagnosis, and clinical significance. Ann Pharmacother. 2010;44(5):844-50. DOI: 10.1345/ aph.1M52610.1345/aph.1M52620332341]Search in Google Scholar
[6. Wang Y, Hu YJ, Ai XM, Xu HT, Sun TY. Prevalence and clinical prognosis of heteroresistant vancomycin- intermediate Staphylococcus aureus in a tertiary care center in China. Chin Med J 2013;126(3):505-9.]Search in Google Scholar
[7. Tenover FC, Moellering RC Jr. The rationale for revising the Clinical and Laboratory Standards Institute vancomycin minimal inhibitory concentration interpretive criteria for Staphylococcus aureus. Antimicrob Agents Chemoter. 2007;48:4926-8.]Search in Google Scholar
[8. EUCAST. European Committee on Antimicrobial Susceptibility Testing Breakpoint tables for interpretation of MICs and zone diameters, Version 2.0. http://www. eucast.org/fileadmin/src/media/PDFs/EUCAST_files/ Breakpoint_tables/Breakpoint_table_v_2.0_120221. pdf.]Search in Google Scholar
[9. EUCAST guidelines for detection of resistance mechanisms and specific resistances of clinical and/or epidemiological importance. December 2012. http://www. eucast.org/fileadmin/src/media/PDFs/EUCAST_files/ Consultation/EUCAST_guidelines_detection_of_resistance_ mechanisms_121222.pdf.]Search in Google Scholar
[10. Székely E, Man A, Mare A, Vas KE, Molnár Sz, Bilca D, et al. Molecular epidemiology and virulence factors of methicillin-resistant Staphylococcus aureus strains in a Romanian university hospital. Rev Romana Med Lab. 2012;20(4):371-82.]Search in Google Scholar
[11. Wootton M, Howe RA, Hillman R, Walsh TR, Bennett PM, MacGowan AP. A modified population analysis profile method to detect Staphylococcus aureus with decreased susceptibilities to vancomycin in a UK hospital. J Antimicrob Chemother. 2001;47(4):399-404. DOI: 10.1093/jac/47.4.39910.1093/jac/47.4.39911266410]Search in Google Scholar
[12. Riederer K, Shemes S, Chase P, Musta A, Mar A, Khatib R. Detection of intermediately vancomycin-susceptible and heterogeneous Staphylococcus aureus isolates: comparison of Etest and Agar Screening Methods. J Clin Microbiol. 2011;49(6):2147-50. DOI: 10.1128/ JCM.01435-1010.1128/JCM.01435-10312276221490190]Search in Google Scholar
[13. Shopsin B, Mathema B, Alcabes P, Said-Salim B, Lina G, Matsuka A, et al. Prevalence of agr specificity groups among Staphylococcus aureus strains colonizing children and their guardians. J Clin Microbiol. 2003;41(1):456-9. DOI: 10.1128/JCM.41.1.456-459.200310.1128/JCM.41.1.456-459.200314958312517893]Search in Google Scholar
[14. Howden BP, Davies JK, Johnson PDR, Stinear TP, Grayson ML. Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate dtrains: resistance mechanisms, laboratory detection, and clinical implications. Clin Microbiol Rev. 2010;23(1):99-139. DOI: 10.1128/CMR.00042-0910.1128/CMR.00042-09280665820065327]Search in Google Scholar
[15. Kirby A, Graham R, Williams NJ, Wootton M, Broughton CM, Alanazi M, et al. Staphylococcus aureus with reduced glycopeptide susceptibility in Liverpool, UK. J Antimicrob Chemother. 2010(4);65:721-4. DOI: 10.1093/jac/dkq00910.1093/jac/dkq00920124288]Search in Google Scholar
[16. Campanile F, Borbone S, Perez M, Bongiorno D, Cafiso V, Bertuccio T, et al. Heteroresistance to glycopeptides in Italian meticillin-resistant Staphylococcus aureus (MRSA) isolates. International Journal of Antimicrobial Agents 2010;36(5):415-34. DOI: 10.1016/j. ijantimicag.2010.06.044]Search in Google Scholar
[17. Reverdy ME, Jarraud S, Bobin-Dubreux S, Burel E, Girado P, Lina G, et al. Incidence of Staphylococcus aureus with reduced susceptibility to glycopeptides in two French hospitals. Clin Microbiol Inf. 2001;7(5):267-72. DOI: 10.1046/j.1198-743x.2001.00256.x10.1046/j.1198-743x.2001.00256.x11422254]Search in Google Scholar
[18. Nonhoff C, Denis O, Struelens MJ. Low prevalence of methicillin-resistant Staphylococcus aureus with reduced susceptibility to glycopeptides in Belgian hospitals. Clinical Microbiology and Infection, 2005;11(3):214-20. DOI: 10.1111/j.1469-0691.2004.01060.x10.1111/j.1469-0691.2004.01060.x15715719]Search in Google Scholar
[19. Denis O, Nonhoff C, Byl B, Knoop C, Bobin-Dubreux S, Struelens MJ. Emergence of vancomycin-intermediate Staphylococcus aureus in a Belgian hospital: microbiological and clinical features. J Antimicrob Chemother. 2002;50(3):383-91. DOI: 10.1093/jac/dkf14210.1093/jac/dkf14212205063]Search in Google Scholar
[20. Rybak MJ, Leonard SN, Rossi KL, Cheung CM, Sadar HS, Jones RN. Characterization of vancomycin-heteroresistant Staphylococcus aureus from the metropolitan area of Detroit, Michigan, over a 22-year period (1986 to 2007). J Clin Microbiol. 2008;46(9):2950-4. DOI: 10.1128/JCM.00582-0810.1128/JCM.00582-08254672518632899]Search in Google Scholar
[21. Horne KC, Howden BP, Grabsch EA, Graham M, Ward PD, Xie S, et al. Prospective comparison of the clinical impact of heterogeneous vancomycin-intermediate methicillin-resistant Staphylococcus aureus (MRSA) and vancomycinsusceptible MRSA. Antimicrob Agents Chemother. 2009;53(8):3447-52. DOI: 10.1128/ AAC.01365-0810.1128/AAC.01365-08271562419506056]Search in Google Scholar
[22. Tóth A, Kispál G, Ungvári E, Violka M, Szeberin Z, Pászti J. First report of heterogeneously vancomycin-intermediate Staphylococcus aureus (hVISA) causing fatal infection in Hungary. J Chemother. 2008;20(5):655-6. DOI: 10.1179/joc.2008.20.5.65510.1179/joc.2008.20.5.65519028632]Search in Google Scholar
[23. Dorneanu OS, Vremeră T, Năstase EV, Logigan C, Bădescu AC, Miftode EG. Detection of mecA gene in clinical Staphylococcus aureus isolates from Infectious Diseases Hospital, Iasi, Romania. Rev Romana Med Lab. 2011;19(3):259-65.]Search in Google Scholar
[24. Ionescu R, Mediavilla JR, Chen L, Grigorescu DO, Idomir M, Kreiswirth BN, et al. Molecular characterization and antibiotic susceptibility of Staphylococcus aureus from a multidisciplinary hospital in Romania. Microb Drug Resist. 2010;16(4):263-72. DOI: 10.1089/ mdr.2010.005910.1089/mdr.2010.005921034225]Search in Google Scholar
[25. Sader HS, Jones RN, Rossi KL, Rybak MJ. Occurrence of vancomycin-tolerant and heterogeneous vancomycin- intermediate strains (hVISA) among Staphylococcus aureus causing bloodstream infections in nine USA hospitals. J Antimicrob Chemother. 2009;64(5):1024-8. DOI: 10.1093/jac/dkp31910.1093/jac/dkp31919744978]Search in Google Scholar
[26. Yusof A, Engelhardt A, Karlsson A, Bylund L, Vidh P, Mills K, et al. Evaluation of a new Etest vancomycin-teicoplanin strip for detection of glycopeptide-intermediate Staphylococcus aureus (GISA) in particular, heterogeneous GISA. J Clin Microbiol. 2008;46(9):3042-7. DOI: 10.1128/JCM.00265-0810.1128/JCM.00265-08254675418596146]Search in Google Scholar
[27. Filleron A, Chiron R, Reverdy ME, Jean-Pierre H, Du mitrescu O, Aleyrangues L, et al. Utility of the Etest GRD for detecting Staphylococcus aureus with reduced susceptibility to glycopeptides in cystic fibrosis patients. Eur J Clin Microbiol Infect Dis. 2012;31(4):599-604. DOI: 10.1007/s10096-011-1353-410.1007/s10096-011-1353-421904858]Search in Google Scholar
[28. Leonard SN, Rossi KL, Newton KL, Rybak MJ. Evaluation of the Etest GRD for the detection of Staphylococcus aureus with reduced susceptibility to glycopeptides. J Antimicrob Chemother. 2009;63(3):489-92. DOI: 10.1093/jac/dkn52010.1093/jac/dkn52019136530]Search in Google Scholar
[29. Walsh TR, Bolmstrom A, Qwarnstrom A, Ho P, Wootton M, Howe RA, et al. Evaluation of current methods for detection of staphylococci with reduced susceptibility to glycopeptides. J Clin Microbiol. 2001;39(7):2439-44. DOI: 10.1128/JCM.39.7.2439-2444.200110.1128/JCM.39.7.2439-2444.20018816711427551]Search in Google Scholar
[30. Vaudaux P, Huggler E, Bernard L, Ferry T, Renzoni A, Lew DP. Underestimation of Vancomycin and Teicoplanin MICs by Broth Microdilution Leads to Underdetection of Glycopeptide-Intermediate Isolates of Staphylococcus aureus. Antimicrob Agents Chemother. 2010;54(9):3861-70. DOI: 10.1128/AAC.00269-1010.1128/AAC.00269-10293498120547791]Search in Google Scholar
[31. CDC. Algorithm for testing S. aureus with vancomycin. http://www.cdc.gov/HAI/settings/lab/visa_vrsa_algorithm. html. [Online]]Search in Google Scholar
[32. Wootton M, MacGowan AP, Walsh TR, Howe RA. A multicenter study evaluating the current strategies for isolating Staphylococcus aureus strains with reduced susceptibility to glycopeptides. J. Clin. Microbiol. 2007;45(2):329-32. DOI: 10.1128/JCM.01508-0610.1128/JCM.01508-06182900617108069]Search in Google Scholar
[33. Voss A, Mouton JW, van Elzakker EP, Hendrix RG, Goessens W, Kluytmans AJ, et al. A multi-center blinded study on the efficiency of phenotypic screening methods to detect glycopeptide intermediately susceptible Staphylococcus aureus (GISA) and heterogeneous GISA (h-GISA). Ann Clin Microbiol Antimicrob. 2007;6:9. DOI: 10.1186/1476-0711-6-910.1186/1476-0711-6-9203458017892555]Search in Google Scholar
[34. ECDC. EARSS Manual 2005. http://www.ecdc.europa. eu/en/activities/surveillance/ears-net/documents/ ears-net-microbiological-manual.pdf. [Online]]Search in Google Scholar
[35. Fitzgibbon MM, Rossney AS, O’Connell B. Investigation of reduced susceptibility to glycopeptides among methicillin-resistant Staphylococcus aureus isolates from patients in Ireland and evaluation of agar screening methods for detection of heterogeneously glycopeptide-intermediate S. aureus. J Clin Microbiol. 2007;45(10):3263-9. DOI: 10.1128/JCM.00836-0710.1128/JCM.00836-07204535517687008]Search in Google Scholar
[36. Sakoulas G, Eliopoulos GM, Moellering RC Jr., Wennersten C, Venkataraman L, Novick RP, et al. Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin. Antimicrob Agents Chemother. 2002;46(5):1492-502. DOI: 10.1128/AAC.46.5.1492-1502.200210.1128/AAC.46.5.1492-1502.200212715311959587]Search in Google Scholar
[37. Sakoulas G, Eliopoulos GM, Moellering RC Jr., Novick RP, Venkataraman L, Wennersten C, et al. Staphylococcus aureus accessory gene regulator (agr) group II: is there a relationship to the development of intermediate- level glycopeptide resistance? J Infect Dis. 2003;187(6):929-38. DOI: 10.1086/36812810.1086/36812812660939]Search in Google Scholar
[38. Tsuji BT, Rybak MJ, Lau KL, Sakoulas G. Evaluation of accessory gene regulator (agr) group and function in the proclivity towards vancomycin intermediate resistance in Staphylococcus aureus. Antimicrob Agents Chemother. 2007;51(3):1089-91. DOI: 10.1128/ AAC.00671-0610.1128/AAC.00671-06180312317158941]Search in Google Scholar
[39. Casapao AM, Leonard SN, Davis SL, Lodise TP, Patel N, Goff DA, et al. Clinical outcomes in patients with heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) bloodstream infection. Antimicrob Agents Chemother. 2013[Epub ahead of print]. DOI: 10.1128/AAC.00380-1310.1128/AAC.00380-13375432723796929]Search in Google Scholar
[40. Fong RK, Low J, Koh TH, Kurup A. Clinical features and treatment outcomes of vancomycin-intermediate Staphylococcus aureus (VISA) and heteroresistant vancomycin- intermediate Staphylococcus aureus (hVISA) in a tertiary care institution in Singapore. Eur J Clin Microbiol Infect Dis. 2009;28(8):983-7. DOI: 10.1007/ s10096-009-0741-510.1007/s10096-009-0741-519387707]Search in Google Scholar
[41. Maor Y, Hagin M, Belausov N, Keller N, Ben-David D, Rahav G. Clinical features of heteroresistant vancomycin- intermediate Staphylococcus aureus bacteremia versus those of methicillin-resistant S. aureus bacteremia. J Infect Dis. 2009;199(5):619-24. DOI: 10.1086/59662910.1086/59662919199552]Search in Google Scholar
[42. Park KH, Kim ES, Kim HS, Park SJ, Bang KM, Park HJ, et al. Comparison of the clinical features, bacterial genotypes and outcomes of patients with bacteraemia due to heteroresistant vancomycin-intermediate Staphylococcus aureus and vancomycin-susceptible S. aureus. J Antimicrob Chemother. 2012;67(8):1843-9. DOI: 10.1093/jac/dks13110.1093/jac/dks13122535621]Search in Google Scholar
[43. Khatib R, Jose J, Musta A, Sharma M, Fakih MG, Johnson LB, et al. Relevance of vancomycin-intermediate susceptibility and heteroresistance in methicillin-resistant Staphylococcus aureus bacteraemia. J Antimicrob Chemother. 2011;66(7):1594-9. DOI: 10.1093/jac/ dkr169]Search in Google Scholar
[44. Soriano A, Marco F, Martínez JA, Pisos E Almela M, Dimova VP, et al. Influence of vancomycin minimum inhibitory concentration on the treatment of methicillin- resistant Staphylococcus aureus bacteremia. Clin Infect Dis. 2008;46(2):193-200. DOI: 10.1086/52466710.1086/52466718171250]Search in Google Scholar
[45. Sakoulas G, Moellering RC Jr., Eliopoulos GM. Ad aptation of methicillin-resistant Staphylococcus aureus in the face of vancomycin therapy. Clin Infect Dis 2006;42(Suppl 1):40-50. DOI: 10.1086/49171310.1086/49171316323119]Search in Google Scholar
[46. Musta AC, Riederer K, Shemes S, Chase P, Jose J, Johnson LB, et al. Vancomycin MIC plus heteroresistance and outcome of methicillin-resistant Staphylococcus aureus bacteremia: trends over 11 years. J Clin Microbiol. 2009;47(6):1640-4. DOI: 10.1128/JCM.02135-0810.1128/JCM.02135-08269107819369444]Search in Google Scholar