1. bookVolume 21 (2013): Edition 2 (June 2013)
Détails du magazine
License
Format
Magazine
eISSN
2284-5623
ISSN
2284-5623
Première parution
08 Aug 2013
Périodicité
4 fois par an
Langues
Anglais
access type Accès libre

Monoclonal B cell lymphocytosis in patients with hepatitis C virus infection: prevalence, demographic and laboratory correlations

Publié en ligne: 21 Jun 2013
Volume & Edition: Volume 21 (2013) - Edition 2 (June 2013)
Pages: 209 - 215
Détails du magazine
License
Format
Magazine
eISSN
2284-5623
ISSN
2284-5623
Première parution
08 Aug 2013
Périodicité
4 fois par an
Langues
Anglais
Abstract

Hepatitis C virus is known to be a risk factor for the development of B-cell non-Hodgkin lymphoma. Studies investigating the prevalence of hepatitis C virus in lymphoma report controversial results, depending on the geographical area. Monoclonal B lymphocytosis is an asymptomatic condition which can evolve into malignant lymphoma, characterized by the presence of a circulating clonal B population. It can be detected by flow cytometry and it is found at higher prevalence in hepatitis C virus-infected patients than in the general population. In the literature, there are only a few studies investigating its prevalence in hepatitis C infected patients and in Romania, such a study hasn’t been carried out before. We conducted a prospective study on 50 hepatitis C virus-infected patients from the Regional Institute of Gastroenterology and Hepatology Prof. Dr. Octavian Fodor. Clinical and laboratory data were collected from the medical files. Flow cytometric analysis was carried out at the Immunology Department of the Emergency County Hospital Cluj Napoca. We have found a prevalence of 22% of monoclonal B lymphocytosis. There were no statistical differences between patients with or without monoclonality, except for the lower leucocyte count (p=0.04) and the more increased liver echogenicity in patients with monoclonality (p=0.02). All of the 3 subtypes of monoclonal B lymphocytosis were found. Increased prevalence of monoclonal B lymphocytosis in patients with hepatitis C virus infection sustains the virus role in lymphomagenesis, but further studies are needed to analyze the rate of transformation into lymphoma in these patients.

Keywords

Cuvinte cheie

1. Turner NC, Dusheiko G and Jones A. Hepatitis C and B-cell lymphoma. Ann Oncol 2003;14:1341-134510.1093/annonc/mdg36312954572Search in Google Scholar

2. Zignego AL, Gianinni C, Ferri C. Hepatitis C virus-related lymphoproliferative disorders: an overview. World J Gastroenterol 2007;13(17):2467-2475.10.3748/wjg.v13.i17.2467414676617552031Search in Google Scholar

3. Vlădăreanu A-M. Limfoamele în corelaţie cu virusurile limfotrope. Editura Amaltea 2007.Cap. Limfoamele maligne şi virusurile hepatitice. Pag. 63-93Search in Google Scholar

4. Ferri C, Caracciolo F, Zignego AL, La Civita L, Monti M, Longombardo G et al. Hepatitis C virus infection in patients with non-Hodgkin’s lymphoma. Br J Haematol. 1994;88(2):392-394.10.1111/j.1365-2141.1994.tb05036.x7803287Search in Google Scholar

5. Pozzato G, Mazzaro C, Crovatto M, Modolo ML, Ceselli S, Mazzi G, et al. Low-grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia. Blood. 1994 Nov 1;84(9):3047-53.10.1182/blood.V84.9.3047.bloodjournal8493047Search in Google Scholar

6. Mele A, Pulsoni A, Bianco E, Musto P, Szklo A, Sanpaolo MG et al. Hepatitis C virus and B-cell non- Hodgkin lymphomas: an italian multicenter case- control study. Blood. 2003;102(3):996-999.10.1182/blood-2002-10-323012714514Search in Google Scholar

7. Duberg A-S, Nordstrom M, Torner A, Reichard O, Strauss R, Janson R et al. Non-Hodgkin’s lymphoma and other neoplastic malignancies in Swedish patients with hepatitis C virus infection. Hepatology. 2005;41(3):652-659.10.1002/hep.2060815723449Search in Google Scholar

8. Anderson LA, Pfeiffer R, Warren JL, Landgren O, Gadalla S, Berndt SI et al. Hematopoietic malignancies associated with viral and alcoholic hepatitis. Cancer Epidemiol Biomarkers Prev.2008;17(11):3069-75.10.1158/1055-9965.EPI-08-0408259745318957521Search in Google Scholar

9. Del Masso L, Franceschi S. Hepatitis C virus and risk of lymphoma and other lymphoid neoplasms: a meta-analysis of epidemiologic studies. Cancer Epidemiol Biomarkers Prev.2006;15(11):2078-2085.10.1158/1055-9965.EPI-06-030817119031Search in Google Scholar

10. Imai Y, Oshawa M, Tanaka H. High prevalence of HCV infection in patients with B-cell non-Hodgkin’s lymphoma: comparison with birth cohort-and sex-matched blood donors in a Japanese population. Hepatology. 2002;35:974-6.10.1053/jhep.2002.3214911915049Search in Google Scholar

11. Al-Ghiti AAO, Arbanas T, Diculescu M. Epidemiological characteristics of hepatitis C and B viral infection in patients with lymphoproliferations sustain their role in lymphomagenesis. Medica. 2006;4(1):5-11.Search in Google Scholar

12. Yenice N, Gulluk F, Arican N, Turkmen S. HCV prevalence in Hodgkin and non-Hodgkin lymphoma cases. Turk J Gastroenterol 2003;14(3):173-176.Search in Google Scholar

13. Kuniyoshi M, Nakamuta M, Sakai H, Enjoji M, Kinukawa N, Kotoh K et al. Prevalence of hepatitis B or C virus infection in patients with non-Hodgkin’s lymphoma. J Gastroenterol Hepatol 2001;16(2):215-9.10.1046/j.1440-1746.2001.02406.x11207904Search in Google Scholar

14. Kang J, Cho JH, Suh SW, Lee DH, Oh HB, Sohn YH et al. High prevalence of hepatitis B and hepatitis C virus infections in Korean patients with hematopoietic malignancies. Ann Hematol 2011;90(2):159-64.10.1007/s00277-010-1055-5Search in Google Scholar

15. De Rosa G, Gabbo ML, De Renzo A. High prevalence of hepatitis C virus infections in patients with B-cell lymphoproliferative disorders in Italy. Am J Hematol 1997;55:77-82.10.1002/(SICI)1096-8652(199706)55:2<77::AID-AJH5>3.0.CO;2-#Search in Google Scholar

16. Zucca E, Roggero E, Maggi-Solca N, Conconi A, Bertoni F, Reilly I et al. Prevalence of Helicobacter Pylori and hepatitis C virus infections among non-Hodgkin’s lymphoma patients in Southern Switzerland. Haematologica 2000;85:147-153.Search in Google Scholar

17. Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute- Working Group 1996 guidelines. Blood. 2008 Jun 15;111(12):5446-56.10.1182/blood-2007-06-093906Search in Google Scholar

18. Mowery YM, Lanasa MC. Clinical aspects of monoclonal B-cell lymphocytosis. Cancer Control. 2012 Jan;19(1):8-17.10.1177/107327481201900102Search in Google Scholar

19. Ghia P. Another piece in the puzzle: is there a “nodal” monoclonal B-cell lymphocytosis? Haematologica 2011;96(8):1089-1091.Search in Google Scholar

20. Matos DM, Falcão RP. Monoclonal B-cell lymphocytosis: a brief review for general clinicians. Sao Paulo Med J. 2011 May;129(3):171-5.10.1590/S1516-31802011000300008Search in Google Scholar

21. Marti G E, Rawstron A C, Ghia P, Hillmen P, Houlston RS, Kay N et al. Diagnostic criteria for monoclonal B-cell lymphocytosis. Br J Haematol 2005;130:325-332.10.1111/j.1365-2141.2005.05550.xSearch in Google Scholar

22. Rawstron A C, Green M J, Kuzmicki A, Kennedy B, Fenton JA, Evans PA et al. Monoclonal B lymphocytes with the characteristics of “indolent” chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Blood 2002;100:635-639.Search in Google Scholar

23. Ohtsubo K, Sata M, Kawaguchi T, Morishige S, Takata Y, Oku E, Imamura R et al. Characterisation of the light chain-restricted clonal B cells in peripheral blood of HCV- positive patients. Int J Hematol 2009;89(4):452-459.10.1007/s12185-009-0301-xSearch in Google Scholar

24. Johansson P, De Dechene E M, Eisele L, Kieruzel S, Horn P, Schmucker U et al. Increased prevalence of monoclonal B lymphocytosis in patients with chronic hepatitis C. Journal of Hepatology 2010;52(1):274.10.1016/S0168-8278(10)60707-6Search in Google Scholar

25. Fazi C, Dagklis A, Cottini F, Scarfo L, Bertilaccio MT, Finazzi R et al. Monoclonal B cell lymphocytosis in hepatitis C virus infected individuals. Cytometry B Clin Cytom 2010;78(1):61-8.10.1002/cyto.b.20545Search in Google Scholar

Articles recommandés par Trend MD

Planifiez votre conférence à distance avec Sciendo