<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Malignant peripheral nerve sheath tumors are a type of soft tissue sarcoma deriving from Schwann cells that usually appear in type 1 neurofibromatosis patients but also sporadically. Tumors frequently interest the nerves in the limbs. They represent a therapeutical challenge due to difficulty of resection and relative radio-resistance and chemo-resistance. The paper aims to describe targeted therapy used in this setting and news concerning the molecular changes that lead to carcinogenesis initiation and promotion. A short selection of literature data was made using PRISMA criteria on this topic. However, due to the rarity and heterogeneity of these tumors, personalized treatment is necessary.</p></abstract>

Malignant peripheral nerve sheath tumors are a type of soft tissue sarcoma deriving from Schwann cells that usually appear in type 1 neurofibromatosis patients but also sporadically. Tumors frequently interest the nerves in the limbs. They represent a therapeutical challenge due to difficulty of resection and relative radio-resistance and chemo-resistance. The paper aims to describe targeted therapy used in this setting and news concerning the molecular changes that lead to carcinogenesis initiation and promotion. A short selection of literature data was made using PRISMA criteria on this topic. However, due to the rarity and heterogeneity of these tumors, personalized treatment is necessary.

Trends in systemic therapy for malignant peripheral nerve sheath tumors

“Elias” University Emergency Hospital

“Carol Davila” University of Medicine and Pharmacy

Romanian Journal of Orthopaedic Surgery and Traumatology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Trends in systemic therapy for malignant peripheral nerve sheath tumors"}

Malignant peripheral nerve sheath tumors are a type of soft tissue sarcoma deriving from Schwann cells that usually appear in type 1 neurofibromatosis patients...

Trends in systemic therapy for malignant peripheral nerve sheath tumors

Publié en ligne: 01 févr. 2020

Pages: 139 - 142

DOI: https://doi.org/10.2478/rojost-2019-0025

Mots clés
limb sarcoma, peripheral nerve sheath tumor

© 2019 Lucian Alecu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Trends in systemic therapy for malignant peripheral nerve sheath tumors

Publié en ligne: 01 févr. 2020

Pages: 139 - 142

DOI: https://doi.org/10.2478/rojost-2019-0025

Mots cléslimb sarcoma, peripheral nerve sheath tumor

© 2019 Lucian Alecu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
limb sarcoma, peripheral nerve sheath tumor