<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>BACKGROUND.</bold> Angiosarcoma is a neoplastic tumor that originates from endothelial cells, accounting for less than 2% of all sarcomas. The sinonasal localization of angiosarcoma is uncommon. It is a highly aggressive tumor with an increased risk of local recurrence.
<bold>CASE REPORT.</bold> We present the case of a 24-year-old male patient with 1 month of left side epistaxis, left nasal obstruction, headache and left hemifacial paresthesia. The CT scan of the skull and paranasal sinuses performed with intravenous contrast showed a macronodular heterogenous tissue lesion, partially hyperdense spontaneously, iodophilic, with multiple vascular trajectories apparently of the arterial type, localised in the left maxillary sinus and ipsilateral nasal cavity. The first result from histopathological examination concluded for sinonasal angiofibroma with no signs of malignancy. Even if a wide resection was performed by external and endoscopic approach, a quite quick local recurrence appeared. After the second surgical resection of the tumor, the histopathological examination correlated with immunohistochemical tests and the clinical-imaging aspect concluded on sinonasal angiosarcoma. The proper treatment was delayed because of the histopathological examination misinterpretation.
<bold>CONCLUSION.</bold> A thorough histopathological examination and immunohistochemistry have an important role for an adequate diagnosis of sinonasal angiosarcoma.
</abstract>

BACKGROUND. Angiosarcoma is a neoplastic tumor that originates from endothelial cells, accounting for less than 2% of all sarcomas. The sinonasal localization of angiosarcoma is uncommon. It is a highly aggressive tumor with an increased risk of local recurrence.
CASE REPORT. We present the case of a 24-year-old male patient with 1 month of left side epistaxis, left nasal obstruction, headache and left hemifacial paresthesia. The CT scan of the skull and paranasal sinuses performed with intravenous contrast showed a macronodular heterogenous tissue lesion, partially hyperdense spontaneously, iodophilic, with multiple vascular trajectories apparently of the arterial type, localised in the left maxillary sinus and ipsilateral nasal cavity. The first result from histopathological examination concluded for sinonasal angiofibroma with no signs of malignancy. Even if a wide resection was performed by external and endoscopic approach, a quite quick local recurrence appeared. After the second surgical resection of the tumor, the histopathological examination correlated with immunohistochemical tests and the clinical-imaging aspect concluded on sinonasal angiosarcoma. The proper treatment was delayed because of the histopathological examination misinterpretation.
CONCLUSION. A thorough histopathological examination and immunohistochemistry have an important role for an adequate diagnosis of sinonasal angiosarcoma.

Sinonasal angiosarcoma: case report and literature review

“Carol Davila” University of Medicine and Pharmacy

Romanian Journal of Rhinology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Sinonasal angiosarcoma: case report and literature review"}

BACKGROUND. Angiosarcoma is a neoplastic tumor that originates from endothelial cells, accounting for less than 2% of all sarcomas. The sinonasal localization...

Sinonasal angiosarcoma: case report and literature review

Publié en ligne: 25 juil. 2024

Pages: 141 - 149

Reçu: 26 mars 2024

Accepté: 14 mai 2024

DOI: https://doi.org/10.2478/rjr-2024-0021

Mots clés
sinonasal angiosarcoma, epistaxis, histopathology, immunohistochemistry

© 2024 Andreea Milea et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Sinonasal angiosarcoma: case report and literature review

Publié en ligne: 25 juil. 2024

Pages: 141 - 149

Reçu: 26 mars 2024

Accepté: 14 mai 2024

DOI: https://doi.org/10.2478/rjr-2024-0021

Mots cléssinonasal angiosarcoma, epistaxis, histopathology, immunohistochemistry

© 2024 Andreea Milea et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
sinonasal angiosarcoma, epistaxis, histopathology, immunohistochemistry