<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>OBJECTIVES.</bold> We investigated peripheric and central olfactory pathways on MRI in Chronic Obstructive Pulmonary Disease (COPD) patients and the relationship between olfactory measurements of COPD patients and thorax CT images of emphysema classification in them.
<bold>MATERIAL AND METHODS.</bold> In this retrospective study, cranial MRI of 42 adult patients with COPD and 42 healthy adults without COPD were included. In both groups, peripheral (olfactory bulb (OB) volume and olfactory sulcus (OS) depth) and central olfactory areas (insular gyrus and corpus amygdala areas) were evaluated. We classified thorax CT findings according to emphysema by size as 1 to 4.
<bold>RESULTS.</bold> In the present study, left OB volume of the COPD group was significantly lower than that in the control group (p&lt;0.05). On the right side, there were no significant differences between OB volumes of the COPD and control groups. Although right OB volume values were found to decrease proportionally, they were not found to be statistically significant. Also, insular gyrus and corpus amygdala areas of the COPD group were significantly lower than those in the control group, bilaterally (p&lt;0.05). OS depths of the COPD group were significantly higher than those in the control group, bilaterally (p&lt;0.05). In males, the right OB volume values were higher than those in females (p&lt;0.05).
<bold>CONCLUSION.</bold> In COPD patients, left OB volumes decrease and OS depths increase bilaterally, and central areas decrease bilaterally, regardless of the thoracic emphysema classification. It may be related to hypoxemia that causes airway inflammation; inflammatory mediators may be harmful to the olfactory neuroepithelium.
</abstract>

OBJECTIVES. We investigated peripheric and central olfactory pathways on MRI in Chronic Obstructive Pulmonary Disease (COPD) patients and the relationship between olfactory measurements of COPD patients and thorax CT images of emphysema classification in them.
MATERIAL AND METHODS. In this retrospective study, cranial MRI of 42 adult patients with COPD and 42 healthy adults without COPD were included. In both groups, peripheral (olfactory bulb (OB) volume and olfactory sulcus (OS) depth) and central olfactory areas (insular gyrus and corpus amygdala areas) were evaluated. We classified thorax CT findings according to emphysema by size as 1 to 4.
RESULTS. In the present study, left OB volume of the COPD group was significantly lower than that in the control group (p<0.05). On the right side, there were no significant differences between OB volumes of the COPD and control groups. Although right OB volume values were found to decrease proportionally, they were not found to be statistically significant. Also, insular gyrus and corpus amygdala areas of the COPD group were significantly lower than those in the control group, bilaterally (p<0.05). OS depths of the COPD group were significantly higher than those in the control group, bilaterally (p<0.05). In males, the right OB volume values were higher than those in females (p<0.05).
CONCLUSION. In COPD patients, left OB volumes decrease and OS depths increase bilaterally, and central areas decrease bilaterally, regardless of the thoracic emphysema classification. It may be related to hypoxemia that causes airway inflammation; inflammatory mediators may be harmful to the olfactory neuroepithelium.

Peripheral and central olfactory measurements in Chronic Obstructive Pulmonary Disease patients

Kırıkkale University, Faculty of Medicine

Romanian Journal of Rhinology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

OBJECTIVES. We investigated peripheric and central olfactory pathways on MRI in Chronic Obstructive Pulmonary Disease (COPD) patients and the relationship...

Peripheral and central olfactory measurements in Chronic Obstructive Pulmonary Disease patients

Publié en ligne: 26 juil. 2023

Pages: 103 - 110

Reçu: 30 déc. 2022

Accepté: 23 janv. 2023

DOI: https://doi.org/10.2478/rjr-2023-0017

Mots clés
Chronic Obstructive Pulmonary Disease (COPD), olfactory, cranial MRI, thorax CT, emphysema classification

© 2023 Pelin Zeynep Bekin Sarikaya et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Peripheral and central olfactory measurements in Chronic Obstructive Pulmonary Disease patients

Publié en ligne: 26 juil. 2023

Pages: 103 - 110

Reçu: 30 déc. 2022

Accepté: 23 janv. 2023

DOI: https://doi.org/10.2478/rjr-2023-0017

Mots clésChronic Obstructive Pulmonary Disease (COPD), olfactory, cranial MRI, thorax CT, emphysema classification

© 2023 Pelin Zeynep Bekin Sarikaya et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
Chronic Obstructive Pulmonary Disease (COPD), olfactory, cranial MRI, thorax CT, emphysema classification