A tagging polymorphism in fat mass and obesity-associated (FTO) gene is associated with sepsis status in children

Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition. In this study, we highlight a potential association between a variant of the fat mass and obesity-associated (FTO) gene and risk of sepsis in children and adolescents.

Methods

We investigated a first-intron tagging FTO polymorphism (rs17817449) by comparing a severe condition (SC) group, comprising 598 paediatric patients (ages 0–19 years) admitted to an ICU with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome (MODS), with a control group consisting of 616 healthy young adults.

Results

We observed a lower prevalence (p < 0.01; OR = 0.59, 95% CI = 0.39–0.87) of the FTO TT genotype in febrile and SIRS patients compared to patients with severe illness. There was a borderline trend towards a lower prevalence of the FTO TT genotype in the control group compared to the SC group (p < 0.09, OR = 0.81, 95% CI = 0.62–1.06).

Conclusions

Our findings suggest that rs17817449, a common FTO polymorphism, may be a predictor of sepsis in paediatric patients, and that higher body weight is protective against this clinical complication.

Langue:: Anglais

Périodicité:: 4 fois par an
Sujets de la revue:: Médecine, Médecine clinique, Médecine interne, Médecine interne, autres, Cardiologie, Gastro-entérologie, Rhumatologie

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A tagging polymorphism in fat mass and obesity-associated (FTO) gene is associated with sepsis status in children

Petr Jabandziev

Jaroslav Alois Hubacek

Jaroslav Michalek

Martin Jouza

Jan Papez

Jakub Pecl

Katerina Slaba

Ondrej Slaby

Milan Urik

Stefania Aulicka

Lumir Kunovsky

Jaroslav Michalek

Petr Dominik

Milan Kratochvil

Jozef Klucka

Petr Stourac

Publié en ligne: 12 mars 2024

Pages: 279 - 285

Reçu: 23 oct. 2024

DOI: https://doi.org/10.2478/rjim-2024-0008

Mots cléschild, obesity, sepsis, genotype, genetic predisposition to the disease

© 2024 Petr Jabandziev et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction

Methods

Results

Conclusions

Mots clés
child, obesity, sepsis, genotype, genetic predisposition to the disease