<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Introduction</bold>. Gamma-glutamyltransferase (GGT) is a liver enzyme involved in inflammation and oxidative stress. It is already known that MCP-1 (Monocyte Chemoattractant Protein-1) and TNF-α (tumour necrosis factor) as inflammatory markers, ICAM-1 (Intercellular Adhesion Molecule-1) as an endothelial dysfunctional marker, and glutathione, as an antioxidant, have abnormal levels in type 2 diabetic patients. The aim of this study was to evaluate the specific biological picture of type 2 diabetic patients that also associate higher GGT activity.
<bold>Methods</bold>. Eighty-five type 2 diabetes, aged 40–70 years with a duration of diabetes less than 6 years without infections, epilepsy, chronic liver or cardiac diseases, without alcohol consumption (>20 g/day) were divided in two subgroups, those with normal and those with high abnormal GGT.
<bold>Results</bold>. The diabetic patients with high GGT (n=31) had dysglycaemia, dyslipidemia, higher inflammatory markers (CRP, TNF-α, MCP-1) and endothelial dysfunction (high leptin and sICAM). sICAM, serum MCP-1 and TNF-α levels had significant correlations with GGT activity (r= 0.38, r=0.30 and 0.26 respectively, p&lt;0.05).
<bold>Conclusion</bold>. This study underlines that in non-alcoholic diabetic patients, with a duration of the metabolic disease less than 6 years, sICAM, serum MCP-1 and TNF-α might play an important role in dysmetabolism, and higher level for GGT represents the „red flag” for this condition.
</abstract>

Introduction. Gamma-glutamyltransferase (GGT) is a liver enzyme involved in inflammation and oxidative stress. It is already known that MCP-1 (Monocyte Chemoattractant Protein-1) and TNF-α (tumour necrosis factor) as inflammatory markers, ICAM-1 (Intercellular Adhesion Molecule-1) as an endothelial dysfunctional marker, and glutathione, as an antioxidant, have abnormal levels in type 2 diabetic patients. The aim of this study was to evaluate the specific biological picture of type 2 diabetic patients that also associate higher GGT activity.
Methods. Eighty-five type 2 diabetes, aged 40–70 years with a duration of diabetes less than 6 years without infections, epilepsy, chronic liver or cardiac diseases, without alcohol consumption (>20 g/day) were divided in two subgroups, those with normal and those with high abnormal GGT.
Results. The diabetic patients with high GGT (n=31) had dysglycaemia, dyslipidemia, higher inflammatory markers (CRP, TNF-α, MCP-1) and endothelial dysfunction (high leptin and sICAM). sICAM, serum MCP-1 and TNF-α levels had significant correlations with GGT activity (r= 0.38, r=0.30 and 0.26 respectively, p<0.05).
Conclusion. This study underlines that in non-alcoholic diabetic patients, with a duration of the metabolic disease less than 6 years, sICAM, serum MCP-1 and TNF-α might play an important role in dysmetabolism, and higher level for GGT represents the „red flag” for this condition.

The importance of the enzyme Gamma-glutamyltransferase in the pathogenic cluster in type2 diabetic patient

“Carol Davila” University of Medicine and Pharmacy

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction. Gamma-glutamyltransferase (GGT) is a liver enzyme involved in inflammation and oxidative stress. It is already known that MCP-1 (Monocyte...

The importance of the enzyme Gamma-glutamyltransferase in the pathogenic cluster in type2 diabetic patient

Publié en ligne: 20 févr. 2024

Pages: 203 - 209

Reçu: 12 févr. 2024

DOI: https://doi.org/10.2478/rjim-2024-0006

Mots clés
alanine aminotransferase, chemoattractant protein 1, monocyte, gamma glutamyl transpeptidase, insulin resistance, intercellular Adhesion Molecule-1, oxidative stress, Tumor Necrosis Factor-α, type 2 diabetes mellitus

© 2024 Bogdana Virgolici et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The importance of the enzyme Gamma-glutamyltransferase in the pathogenic cluster in type2 diabetic patient

Publié en ligne: 20 févr. 2024

Pages: 203 - 209

Reçu: 12 févr. 2024

DOI: https://doi.org/10.2478/rjim-2024-0006

Mots clésalanine aminotransferase, chemoattractant protein 1, monocyte, gamma glutamyl transpeptidase, insulin resistance, intercellular Adhesion Molecule-1, oxidative stress, Tumor Necrosis Factor-α, type 2 diabetes mellitus

© 2024 Bogdana Virgolici et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
alanine aminotransferase, chemoattractant protein 1, monocyte, gamma glutamyl transpeptidase, insulin resistance, intercellular Adhesion Molecule-1, oxidative stress, Tumor Necrosis Factor-α, type 2 diabetes mellitus