EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases
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TEMESGEN W., WATCHEL M., DISSANAIKE S. Osteoclastic giant tumor of the pancreas. Int J Surg Case Rep. 2014; 5(4): 175–179.Search in Google Scholar
JALLOH SS. Giant cell tumour (osteoclastoma) of the pancreas – an epithelial tumour probably of pancreatic acinar origin. J Clin Pathol. 1983;36(10):1171–75.Search in Google Scholar
LEWANDROWSKI K., WESTON L., DICKERSIN GR., RATTNER D., COMPTON C. Giant cell tumor of the pancreas of mixed osteoclastic and pleomorphic cell type: Evidence for a histogenetic relationship and mesenchymal differentiation. Hum Pathol. 1990;21(11):1184–87.Search in Google Scholar
OBAYASHI O., SHIBASAKI Y., KOAKUTSU T., HAYASHY Y., SHOJI T., HIRAYAMA K., et al. Pancreatic undifferentiated carcinoma with osteoclast-like giant cells curatively resected after pembrolizumb therapy for lung metastases: a case report. BMC Gastroent. 2020; 20: 220.Search in Google Scholar
MURAKI T., REID M, BASTURK O., JANG K., BEDOLLA G., BAGCI P., et al. Undifferentiated Carcinoma with Osteoclastic Giant Cells of the Pancreas: Clinicopathological Analysis of 38 Cases Highlights A More Protracted Clinical Course than Currently Apprecianted. Am J Surg Pathol. 2016; 40(9): 1203–1216.Search in Google Scholar
MOORE J., BENTZ J., HILDEN K., ADLER G. Osteoclastic and pleomorphic giant cell tumors of the pancreas: A review of clinical, endoscopic, and pathologic features. World J Gastrointest Endoscop. 2010; 2(1): 15–19.Search in Google Scholar
GUO Y., RUAN L., WANG Q., LIAN J. Undifferentiated carcinoma with osteoclast-like giant cells of pancreas: a case report with review of the computed tomography findings. Medicine. 2018; 97(48): e13516.Search in Google Scholar
LUCHINI C., PEA A., LIONHEART G., MAFFICINI A., NOTTEGAR A., VERONESE N. et al. Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma. J Pathol. 2017;243(2):148–54.Search in Google Scholar
GONZALES RS. WHO classification. PathologyOutlines.com website. https://pathologyoutlines.com/topic/pancreaswho.html. Accessed June 29th 2022.Search in Google Scholar
RUSTAGI T., RAMPURWALAM M., RAI M., GOLIOTO M. Recurrent acute pancreatitis and persistent hyperamylasemia as a presentation of pancreatic osteoclastic giant cell tumos: an unusual presentation of a rare tumor. Pancreatology. 2011; 11(1): 2–5.Search in Google Scholar
BaAUDITZ J., RUDOLPH B., WERMKE W. Osteoclast-like giant cell tumors of the pancreas and liver. World J Gastroenterol. 2006; 12(48): 7878–7883.Search in Google Scholar
FUKUKURA Y., KUMAGAE Y., HIRAHARA M., HAKAMADA H., NAGANO., NAKAJO M. et al. CT and MRI features of undifferentiated carcinomas with osteoclast-like giant cells of the pancreas: a case series. Abdom Radiol (NY) 2019;44: 1246–1255.Search in Google Scholar
PULI S., BECHTOLD L., BUXBAUM L., Eloubeidi A. How good is endoscopic ultrasound-guided fine-needle aspiration in diagnosing the correct etiology for a solid pancreatic mass?: A meta-analysis and systematic review. Pancreas. 2013 Jan;42(1):20–6.Search in Google Scholar
OH C., KANG H., LEE Y., CHOI J., CHOI S. Diagnostic accuracy of 22/25-gauge core needle in endoscopic ultrasound-guided sampling: systematic review and meta-analysis. Korean J Intern Med (Korean Assoc Intern Med). 2016 Nov;31(6): 1073–83.Search in Google Scholar
ALATAWI A., BEUVON F., GRABAR S., LEBLANC S., CHAUSSADE S., TERRIS B., et al. Comparison of 22G reverse-beveled versus standard needle for endoscopic ultrasound-guided sampling of solid pancreatic lesions. United European Gastroenterol J. 2015 Aug;3(4):343–52.Search in Google Scholar
FACCIORUSSO A., DEL PRETE V., BUCCINO V., PUROHIT P., SETIA P., MUSCATIELLO N. Diagnostic yield of Franseen and Fork-Tip biopsy needles for endoscopic ultrasound-guided tissue acquisition: a meta-analysis. Endosc Int Open. 2019 Oct;7(10):E1221–30.Search in Google Scholar
BANG Y., HEBERT-MAGEE S., NAVANEETHAN U., HASAN K., HAWES R., VARADARAJULU S. Randomized trial comparing the Franseen and Fork-tip needles for EUS-guided fine-needle biopsy sampling of solid pancreatic mass lesions. Gastrointest Endosc. 2018 Jun;87(6):1432–8.Search in Google Scholar
MAKSYMOV V., KHALIFA M., BUSSEY A., CARTER B., HOGAN M. Undifferentiated (Anaplastic) carcinoma of the Pancreas with Osteoclast-Like Giant Cells Showing Various Degree of Pancreas Duct involvement. A Case Report and Literature Review. J Pancreas. 2011; 12(2): 170–176.Search in Google Scholar
MOLBERG H., HEFFESS C., DELGADO R., ALBORES-SAAVEDRA J. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region. Cancer. 1998;82:1279–1287.Search in Google Scholar
SILVERMAN J., DABBS D., FINLEY J., GEISINGER K. Fine needle Aspiration of Pleomorphic (giant cell) carcinoma of the Pancreas: Cytologic, Immunocytochemical and Ultrastructural Findings. Am Journal of Clinical Pathology. 1988 June; 89(6):714–720.Search in Google Scholar
EZENEKWE A., COLLINS B., PONDER B. Mixed Osteoclastic/Pleomorphic giant cell tumor of the Pancreas. Acta Cytologica. 2005; 42: 549–553.Search in Google Scholar
CHOPRA S., WU M., IMAGAWA D., LEE J., GU M. Endoscopic ultrasound-guided fine-needle aspiration of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: a report of 2 cases with literature review. Diagn Cytopathol. 2007 Sep;35(9):601–6.Search in Google Scholar
LAYFIELD L., BENTZ J. Giant-Cell Containing Neoplasms of the Pancreas: An Aspiration Cytology Study. Diagnost Cytopath. 2008; 36(4):238–244.Search in Google Scholar
MOORE J., HILDEN K., BENTZ J., PEARSON R., ADLER D. Osteoclastic and pleomorphic giant cell tumors of the pancreas diagnosed via EUS-guided FNA: unique clinical, endoscopic, and pathologic findings in a series of 5 patients. Gastrointest Endoscopy. 2009; 69(1):162–166.Search in Google Scholar
WOOHYEON K., LEE I., KIM E., LIM C., KIM J., CHO Y., et al. Undifferentiated carcinoma of the pancreas with osteoclast-like giant cell: Initially diagnosed as solid Pseudopapillary Tumor. Korean Pancreas Biliary Tract. 2016; 21(3): 144–149.Search in Google Scholar
SAKHI R., HAMZA A., KHURRAM M., IBRAR W., MAZZARA P. Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells reported in an asymptomatic patient: a rare case and literature review. Autopsy Case Rep. 2017 Oct–Dec; 7(4): 51–57.Search in Google Scholar
REID D., MURAKI T., HOOKIM K., MEMIS B., GRAHAM R., ALLENDE D., et al. Cytologic features and clinical implications of undifferentiated carcinoma with osteoclastic giant cells of the pancreas: An analysis of 15 cases. Cancer Cytopathol. 2017 Jul;125(7):563–575.Search in Google Scholar
YEPURI N., PRUEKPRASERT N., RAMANI N., FRANCE A., SARPONE J., JAIN A., et al. Osteoclast-like giant cell tumor of the pancreas- an unusual presentation with large mantle cell lymphoma. J Surg Case rep. 2018 dec; (12):rjy341.Search in Google Scholar
HANAYNEH W., PAREKH H., FITZPATRICK G., FEELEY M., GEORGE T., STARR J. Two Cases of Rare Pancreatic Malignancies. J Pancreatic Cancer. 2019 Jul; 5(1):26–33.Search in Google Scholar
NEHMEH W., TRAK-SMAYRA V., TARHINI A., GABRIEL M., SAYEGH R., NOUN R. A Case Report presenting an Undifferentiated Pancreatic Carcinoma with Osteoclast-like Giant Cells with an Unusual Indolent Course. Am J Case Rep. 2019; 20: 1750–1754.Search in Google Scholar
SPEISKY D., VILLARROEL M., VIGOVICH F., IOTTI A., GARCIA T., QUERO L., et al. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas diagnosed by endoscopic ultrasound guided biopsy. Ecancermedicalscience. 2020 Jul 17;14:1072.Search in Google Scholar
KALOGERAKI A., MOUZAS I., KOUTROUBAKIS I., MOUSTON E., LAPPA E., TAMIOLAKIS D., et al. Osteoclast like giant cell undifferentiated pancreatic tumor diagnosed by means of EUS guided FNA. Acta Biomed. 2021 May; 92(2):e2021106.Search in Google Scholar
GAO G., QORBANI A., ZHOU C. A pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) (NET and undifferentiated carcinoma of the pancreas with osteoclast-like giant cells) with metastatic neuroendocrine componen to the liver. Autops Case Rep [nternet]. 2021;11;e2020201.Search in Google Scholar
ASHFAQ A., THALAMBEDU N., ATIQ M. A Rare Case of Pancreatic Cancer: Undifferentiated Carcinoma of the Pancreas with Osteoclast-Like Giant Cells. Cureus14(5): e25118.DOI 10.7759/cureus.25118.Open DOISearch in Google Scholar
IGARASHI Y., GOCHO T., TANIAI T., UWAGAWA T., HAMURA R., SHIRAI Y., et al. Conversion surgery for undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: a case report. Surgical Case Reports (2022)8:42.Search in Google Scholar
ZHANG S., RUGGERI B., AGARWAL P., SORLING A., OBARA T., URA H., et al. Immunohistochemical analysis of p53 expression in human pancreatic carcinomas. Arch Pathol Lab Med. 1994; 118(2): 150–4.Search in Google Scholar
MANNAN R., KHANNA M., BHASIN T., MISRA V., SINGH P. Undifferentiated carcinoma with osteoclast-like giant cell tumor of the pancreas: A discussion of rare entity in comparison with pleomorphic giant cell tumor of the pancreas. Indian J Pathol Microbiol. 2010; 53: 867–8.Search in Google Scholar
SUNGHO JO. Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells. World J Gastroenterol. 2014 20:2725–2730. doi: 10.3748/wjg.v20.i10.2725.Open DOISearch in Google Scholar
SINGHAL A., SHRAGO S., LI F., HUANG Y., KOHLI V. Giant cell tumor of the pancreas: a pathological diagnosis with poor prognosis. Hepatobiliary Pancreat. Dis. Int. 2010;9:433–437.Search in Google Scholar
PISHVAIAN M., BLAIS E., BRODY J., LYONS E., DEARBELOA P., HENDIFAR A., et al. Overall survival in patients with pancreatic cancer receiving matched therapies following molecular profiling: a retrospective analysis of the Know Your Tumor registry trial. Lancet Oncol. 2020;21:508–518.Search in Google Scholar
