<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Introduction:</bold> Increased urinary podocalyxin, a surrogate marker of podocyte detachment, has been shown in preeclampsia and eclampsia, but there is a paucity of data of the effect of normal pregnancy on its urinary excretion. We aimed to describe these changes in this pilot study.
<bold>Methods:</bold> Urine podocalyxin levels were measured in 115 pregnant women. Of these, 12 women were in the second trimester of gestation, 57 in the third trimester and 46 women were in labor.
<bold>Results:</bold> The median [IQR] urinary podocalyxin levels were 0.81 [0.27, 3.68], 0.92 [0.44, 5.49] and 64.7 [30.5, 106.3] ng/mg creatinine in the second trimester, third trimester, and during labor, respectively (p&lt;0.0001). Patients with hematuria during labor had higher levels of urinary podocalyxin (128.6 [79.8, 169.6] ng/mg creatinine. There was a moderate correlation between gestational age and urinary podocalyxin levels (r=0.63, p&lt;0.0001).
<bold>Conclusion:</bold> Urinary podocalyxin levels were low in normal pregnancies and increased significantly during labor and with hematuria.
</abstract>

Introduction: Increased urinary podocalyxin, a surrogate marker of podocyte detachment, has been shown in preeclampsia and eclampsia, but there is a paucity of data of the effect of normal pregnancy on its urinary excretion. We aimed to describe these changes in this pilot study.
Methods: Urine podocalyxin levels were measured in 115 pregnant women. Of these, 12 women were in the second trimester of gestation, 57 in the third trimester and 46 women were in labor.
Results: The median [IQR] urinary podocalyxin levels were 0.81 [0.27, 3.68], 0.92 [0.44, 5.49] and 64.7 [30.5, 106.3] ng/mg creatinine in the second trimester, third trimester, and during labor, respectively (p<0.0001). Patients with hematuria during labor had higher levels of urinary podocalyxin (128.6 [79.8, 169.6] ng/mg creatinine. There was a moderate correlation between gestational age and urinary podocalyxin levels (r=0.63, p<0.0001).
Conclusion: Urinary podocalyxin levels were low in normal pregnancies and increased significantly during labor and with hematuria.

A pilot study of changes in urinary podocalyxin levels during normal pregnancy and labor

Nephrology, Pulmonary and Critical Care Medicine Department

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction: Increased urinary podocalyxin, a surrogate marker of podocyte detachment, has been shown in preeclampsia and eclampsia, but there is a paucity of...

A pilot study of changes in urinary podocalyxin levels during normal pregnancy and labor

Publié en ligne: 22 sept. 2022

Pages: 160 - 165

Reçu: 01 mars 2022

DOI: https://doi.org/10.2478/rjim-2022-0007

Mots clés
hematuria, hypertension, preeclampsia, pregnancy, proteinuria

© 2022 Ylbe Palacios De Franco et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A pilot study of changes in urinary podocalyxin levels during normal pregnancy and labor

Publié en ligne: 22 sept. 2022

Pages: 160 - 165

Reçu: 01 mars 2022

DOI: https://doi.org/10.2478/rjim-2022-0007

Mots cléshematuria, hypertension, preeclampsia, pregnancy, proteinuria

© 2022 Ylbe Palacios De Franco et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
hematuria, hypertension, preeclampsia, pregnancy, proteinuria