1. bookVolume 60 (2022): Edition 2 (June 2022)
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eISSN
2501-062X
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30 Mar 2015
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Anglais
access type Accès libre

Autoimmune polyglandular syndrome type II presenting as subacute combined degeneration of spinal cord: a neuroendocrinology crossroad

Publié en ligne: 14 Jun 2022
Volume & Edition: Volume 60 (2022) - Edition 2 (June 2022)
Pages: 123 - 126
Reçu: 27 Jul 2021
Détails du magazine
License
Format
Magazine
eISSN
2501-062X
Première parution
30 Mar 2015
Périodicité
4 fois par an
Langues
Anglais
Abstract

Introduction: Autoimmune polyglandular syndrome (APS) is a condition having multiple endocrine abnormalities. It is divided into three types depending on the involvement of various endocrinopathies. It is also associated with other systemic involvement. The basic pathophysiology of this syndrome revolves around autoimmunity.

Case presentation: We discuss the case of a 50-year-old gentleman who presented to us in emergency with subacute onset progressive weakness of both lower limbs followed by upper limbs. On examination, patient was confused and disoriented. General examination findings include hypotension, pallor, facial puffiness and vitiligo. Neurological examination revealed spasticity and motor weakness in all four limbs with extensor planter response. Sensory examination during hospital course revealed posterior column involvement. Laboratory and radiological investigations confirmed subacute combined degeneration of spinal cord secondary to pernicious anaemia, Addison’s disease and autoimmune thyroid disease. The final diagnosis of autoimmune polyglandular syndrome type II was made after fulfilment of the required criteria.

Conclusion: Autoimmune polyglandular syndrome type II can rarely present to neurologist as subacute combined degeneration of spinal cord. This syndrome and its systemic association should be kept in mind in order to reach the final diagnosis.

Keywords

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