<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>Incidence of postoperative nausea and vomiting (PONV) in susceptible patients can be unacceptably high (70–80% reported incidence). This study was designed to evaluate the effect of palonosetron and ondansetron in preventing PONV in high-risk patients undergoing gynaecological laparoscopic surgery.</p>
</sec>
<sec><h3>Methodology</h3>
<p>In this randomised, controlled, double-blind trial, nonsmoking females 18–70 years and weighing 40–90 kg, scheduled for elective laparoscopic gynaecological surgeries, were enrolled into the ondansetron (Group A, n=65) or palonosetron (Group B, n=65) group. Palonosetron (1 mcg/kg 4) or ondansetron (0.1 mg/kg 4) were administered just before induction. Postoperatively, incidence of nausea, vomiting, PONV (scored on a scale of 0–3), need for rescue antiemetic, complete response, patient satisfaction, and adverse effects were evaluated for up to 48 h following surgery.</p>
</sec>
<sec><h3>Results</h3>
<p>The overall PONV scores and postoperative nausea score during 0–2 h and 24–48 h were comparable, but PONV scores (P=0.023) and postoperative nausea scores (P=0.010) during 2–24 h were significantly lesser in Group B compared to Group A. There was no statistically significant difference in the postoperative vomiting score or retching during 0–48 h. The amount of first-line rescue antiemetic used during 2–24 h was significantly higher in Group A (56%) than in Group B (31%) (P=0.012; P&lt;0.05). Complete response to the drug during 2–24 h was significantly higher (P=0.023) in Group B (63%) compared to Group A (40%), whereas response was comparable during 0–2 h and 24–48 h. Both groups had comparable incidences of adverse effects and patient satisfaction scores.</p>
</sec>
<sec><h3>Conclusion</h3>
<p>Palonosetron has superior antinausea effect, less need of rescue antiemetics, and lesser incidence of total PONV in comparison to ondansetron during 2–24 h and comparable effect to ondansetron during the 0–2 h and 24–48 h postoperative periods in high-risk patients undergoing gynaecological laparoscopic surgery.</p>
</sec>
</abstract>

Background
Incidence of postoperative nausea and vomiting (PONV) in susceptible patients can be unacceptably high (70–80% reported incidence). This study was designed to evaluate the effect of palonosetron and ondansetron in preventing PONV in high-risk patients undergoing gynaecological laparoscopic surgery.

Methodology
In this randomised, controlled, double-blind trial, nonsmoking females 18–70 years and weighing 40–90 kg, scheduled for elective laparoscopic gynaecological surgeries, were enrolled into the ondansetron (Group A, n=65) or palonosetron (Group B, n=65) group. Palonosetron (1 mcg/kg 4) or ondansetron (0.1 mg/kg 4) were administered just before induction. Postoperatively, incidence of nausea, vomiting, PONV (scored on a scale of 0–3), need for rescue antiemetic, complete response, patient satisfaction, and adverse effects were evaluated for up to 48 h following surgery.

Results
The overall PONV scores and postoperative nausea score during 0–2 h and 24–48 h were comparable, but PONV scores (P=0.023) and postoperative nausea scores (P=0.010) during 2–24 h were significantly lesser in Group B compared to Group A. There was no statistically significant difference in the postoperative vomiting score or retching during 0–48 h. The amount of first-line rescue antiemetic used during 2–24 h was significantly higher in Group A (56%) than in Group B (31%) (P=0.012; P<0.05). Complete response to the drug during 2–24 h was significantly higher (P=0.023) in Group B (63%) compared to Group A (40%), whereas response was comparable during 0–2 h and 24–48 h. Both groups had comparable incidences of adverse effects and patient satisfaction scores.

Conclusion
Palonosetron has superior antinausea effect, less need of rescue antiemetics, and lesser incidence of total PONV in comparison to ondansetron during 2–24 h and comparable effect to ondansetron during the 0–2 h and 24–48 h postoperative periods in high-risk patients undergoing gynaecological laparoscopic surgery.

A Comparative Study of Palonosetron with Ondansetron for Prophylaxis of Postoperative Nausea and Vomiting (PONV) Following Laparoscopic Gynaecological Surgeries

Romanian Journal of Anaesthesia and Intensive Care

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Background
Incidence of postoperative nausea and vomiting (PONV) in susceptible patients can be unacceptably high (70–80% reported incidence). This study was...

A Comparative Study of Palonosetron with Ondansetron for Prophylaxis of Postoperative Nausea and Vomiting (PONV) Following Laparoscopic Gynaecological Surgeries

Article Category: Original Paper

Publié en ligne: 14 janv. 2023

Pages: 32 - 40

DOI: https://doi.org/10.2478/rjaic-2022-0005

Mots clés
Palonosetron, ondansetron, postoperative nausea and vomiting, laparoscopy, gynaecological surgery, general anaesthesia

© 2022 Rohit Balyan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A Comparative Study of Palonosetron with Ondansetron for Prophylaxis of Postoperative Nausea and Vomiting (PONV) Following Laparoscopic Gynaecological Surgeries

Article Category: Original Paper

Publié en ligne: 14 janv. 2023

Pages: 32 - 40

DOI: https://doi.org/10.2478/rjaic-2022-0005

Mots clésPalonosetron, ondansetron, postoperative nausea and vomiting, laparoscopy, gynaecological surgery, general anaesthesia

© 2022 Rohit Balyan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
Palonosetron, ondansetron, postoperative nausea and vomiting, laparoscopy, gynaecological surgery, general anaesthesia