Epidural Analgesia for Labour: Comparing the Effects of Continuous Epidural Infusion (CEI) and Programmed Intermittent Epidural Bolus (PIEB) on Obstetric Outcomes

[1] Brownridge P. (1991). Treatment Options for the Relief of Pain During Childbirth. Drugs. BrownridgeP 1991 Treatment Options for the Relief of Pain During Childbirth Drugs 10.2165/00003495-199141010-000071706989 Search in Google Scholar

[2] Lavand'homme P. (2010). Chronic pain after vaginal and cesarean delivery: a reality questioning our daily practice of obstetric anesthesia. International Journal of Obstetric Anesthesia, 19, 1–2. Lavand'hommeP 2010 Chronic pain after vaginal and cesarean delivery: a reality questioning our daily practice of obstetric anesthesia International Journal of Obstetric Anesthesia 19 1 2 10.1016/j.ijoa.2009.09.00319959352 Search in Google Scholar

[3] Anim-Somuah M, Smyth RM, Jones L. (2011). Epidural versus non-epidural or no analgesia in labour. Cochrane Database Syst Rev., Dec 7. Anim-SomuahM SmythRM JonesL 2011 Epidural versus non-epidural or no analgesia in labour Cochrane Database Syst Rev. Dec 7 10.1002/14651858.CD000331.pub216235275 Search in Google Scholar

[4] Shatalin D, Weiniger CF, Buchman I, Ginosar Y, Orbach-Zinger S, Ioscovich A. (2019). A 10-year update: national survey questionnaire of obstetric anesthesia units in Israel. Int J Obstet Anesth., 38, 83–92. ShatalinD WeinigerCF BuchmanI GinosarY Orbach-ZingerS IoscovichA 2019 A 10-year update: national survey questionnaire of obstetric anesthesia units in Israel Int J Obstet Anesth. 38 83 92 10.1016/j.ijoa.2018.10.01430509678 Search in Google Scholar

[5] Butwick A, Wong C, Guo N. (2018). Maternal Body Mass Index and Use of Labor Neuraxial Analgesia: A Population-based Retrospective Cohort Study. Anesthesiology, 129, 448–58. ButwickA WongC GuoN 2018 Maternal Body Mass Index and Use of Labor Neuraxial Analgesia: A Population-based Retrospective Cohort Study Anesthesiology 129 448 58 10.1097/01.aoa.0000557660.02657.57 Search in Google Scholar

[6] Nanji JA, Carvalho B. (2018). Modern techniques to optimize neuraxial labor analgesia. Anesth Pain Med., 13(3), 233–40. NanjiJA CarvalhoB 2018 Modern techniques to optimize neuraxial labor analgesia Anesth Pain Med. 13 3 233 40 10.17085/apm.2018.13.3.233 Search in Google Scholar

[7] Hasegawa J, Farina A, Turchi G, Hasegawa Y, Zanello M, Baroncini S. (2013). Effects of epidural analgesia on labor length, instrumental delivery, and neonatal short-term outcome. J Anesth., 27(1), 43–7. HasegawaJ FarinaA TurchiG HasegawaY ZanelloM BaronciniS 2013 Effects of epidural analgesia on labor length, instrumental delivery, and neonatal short-term outcome J Anesth. 27 1 43 7 10.1007/s00540-012-1480-922965331 Search in Google Scholar

[8] Leighton BL, Halpern SH. (2002). The effects of epidural analgesia on labor, maternal, and neonatal outcomes: A systematic review. American Journal of Obstetrics and Gynecology. Mosby. LeightonBL HalpernSH 2002 The effects of epidural analgesia on labor, maternal, and neonatal outcomes: A systematic review American Journal of Obstetrics and Gynecology Mosby Search in Google Scholar

[9] Ashwal E, Livne MY, Benichou JIC, Unger R, Hiersch L, Aviram A, et al. (2020). Contemporary patterns of labor in nulliparous and multiparous women. Am J Obstet Gynecol., 222(3), 267.e1–267.e9. AshwalE LivneMY BenichouJIC UngerR HierschL AviramA 2020 Contemporary patterns of labor in nulliparous and multiparous women Am J Obstet Gynecol 222 3 267.e1 267.e9 10.1016/j.ajog.2019.09.03531574290 Search in Google Scholar

[10] Nguyen USDT, Rothman KJ, Demissie S, Jackson DJ, Lang JM, Ecker JL. (2010). Epidural analgesia and risks of cesarean and operative vaginal deliveries in nulliparous and multiparous women. Matern Child Health J., 14(5), 705–12. NguyenUSDT RothmanKJ DemissieS JacksonDJ LangJM EckerJL 2010 Epidural analgesia and risks of cesarean and operative vaginal deliveries in nulliparous and multiparous women Matern Child Health J. 14 5 705 12 10.1007/s10995-009-0515-919760498 Search in Google Scholar

[11] Heesen M, Böhmer J, Klöhr S, Hofmann T, Rossaint R, Straube S. (2015). The effect of adding a background infusion to patient-controlled epidural labor analgesia on labor, maternal, and neonatal outcomes: A systematic review and meta-analysis. Anesth Analg., 121(1), 149–58. HeesenM BöhmerJ KlöhrS HofmannT RossaintR StraubeS 2015 The effect of adding a background infusion to patient-controlled epidural labor analgesia on labor, maternal, and neonatal outcomes: A systematic review and meta-analysis Anesth Analg. 121 1 149 58 10.1213/ANE.000000000000074325902319 Search in Google Scholar

[12] Wang TT, Sun S, Huang SQ. (2017). Effects of epidural labor analgesia with low concentrations of local anesthetics on obstetric outcomes: A systematic review and meta-analysis of randomized controlled trials. Anesthesia and Analgesia, vol. 124. Lippincott Williams and Wilkins, p. 1571–80. WangTT SunS HuangSQ 2017 Effects of epidural labor analgesia with low concentrations of local anesthetics on obstetric outcomes: A systematic review and meta-analysis of randomized controlled trials Anesthesia and Analgesia 124 Lippincott Williams and Wilkins 1571 80 10.1213/ANE.000000000000170927828798 Search in Google Scholar

[13] Xu J, Zhou J, Xiao H, Pan S, Liu J, Shang Y, et al. (2019). A Systematic Review and Meta-Analysis Comparing Programmed Intermittent Bolus and Continuous Infusion as the Background Infusion for Parturient-Controlled Epidural Analgesia. Sci Rep., 9(1). XuJ ZhouJ XiaoH PanS LiuJ ShangY 2019 A Systematic Review and Meta-Analysis Comparing Programmed Intermittent Bolus and Continuous Infusion as the Background Infusion for Parturient-Controlled Epidural Analgesia Sci Rep. 9 1 10.1038/s41598-019-39248-5638489430796286 Search in Google Scholar

[14] Sng BL, Zeng Y, de Souza NNA, Leong WL, Oh TT, Siddiqui FJ, et al. (2018). Automated mandatory bolus versus basal infusion for maintenance of epidural analgesia in labour. Cochrane Database of Systematic Reviews, vol. 2018. John Wiley and Sons. SngBL ZengY de SouzaNNA LeongWL OhTT SiddiquiFJ 2018 Automated mandatory bolus versus basal infusion for maintenance of epidural analgesia in labour Cochrane Database of Systematic Reviews 2018 John Wiley and Sons 10.1002/14651858.CD011344.pub2649458929770432 Search in Google Scholar

[15] Capogna G, Camorcia M, Stirparo S, Farcomeni A. (2011). Programmed intermittent epidural bolus versus continuous epidural infusion for labor analgesia: The effects on maternal motor function and labor outcome. A randomized double-blind study in nulliparous women. Anesth Analg., 113(4), 826–31. CapognaG CamorciaM StirparoS FarcomeniA 2011 Programmed intermittent epidural bolus versus continuous epidural infusion for labor analgesia: The effects on maternal motor function and labor outcome. A randomized double-blind study in nulliparous women Anesth Analg. 113 4 826 31 10.1213/ANE.0b013e31822827b821788309 Search in Google Scholar

[16] Fettes PDW, Moore CS, Whiteside JB, Mcleod GA, Wildsmith JAW. (2006). Intermittent vs continuous administration of epidural ropivacaine with fentanyl for analgesia during labour. Br J Anaesth., 97(3), 359–64. FettesPDW MooreCS WhitesideJB McleodGA WildsmithJAW 2006 Intermittent vs continuous administration of epidural ropivacaine with fentanyl for analgesia during labour Br J Anaesth. 97 3 359 64 10.1093/bja/ael15716849382 Search in Google Scholar

[17] Leo S, Ocampo CE, Lim Y, Sia AT. (2010). A randomized comparison of automated intermittent mandatory boluses with a basal infusion in combination with patient-controlled epidural analgesia for labor and delivery. Int J Obstet Anesth., 19(4), 357–64. LeoS OcampoCE LimY SiaAT 2010 A randomized comparison of automated intermittent mandatory boluses with a basal infusion in combination with patient-controlled epidural analgesia for labor and delivery Int J Obstet Anesth. 19 4 357 64 10.1016/j.ijoa.2010.07.00620832282 Search in Google Scholar

[18] Mowat I, Tang R, Vaghadia H, Krebs C, Henderson WR, Sawka A. (2016). Epidural distribution of dye administered via an epidural catheter in a porcine model. Br J Anaesth., 116(2), 277–81. MowatI TangR VaghadiaH KrebsC HendersonWR SawkaA 2016 Epidural distribution of dye administered via an epidural catheter in a porcine model Br J Anaesth. 116 2 277 81 10.1093/bja/aev43226787798 Search in Google Scholar

[19] Fertility rates (indicator). OECD. 2020. Fertility rates (indicator) OECD 2020 Search in Google Scholar

[20] Hung TH, Hsieh TT an., Liu HP. (2015). Differential effects of epidural analgesia on modes of delivery and perinatal outcomes between nulliparous and multiparous women: A retrospective cohort study. PLoS One., 10(3). HungTH HsiehTT an. LiuHP 2015 Differential effects of epidural analgesia on modes of delivery and perinatal outcomes between nulliparous and multiparous women: A retrospective cohort study PLoS One 10 3 10.1371/journal.pone.0120907437371625807240 Search in Google Scholar

[21] Liu X, Zhang H, Zhang H, Guo M, Gao Y, Du C. (2020). Intermittent epidural bolus versus continuous epidural infusions for labor analgesia: A meta-analysis of randomized controlled trials. PLoS One. LiuX ZhangH ZhangH GuoM GaoY DuC 2020 Intermittent epidural bolus versus continuous epidural infusions for labor analgesia: A meta-analysis of randomized controlled trials PLoS One 10.1371/journal.pone.0234353729242032530935 Search in Google Scholar

[22] Beilin Y, Halpern S. (2010). Ropivacaine versus bupivacaine for epidural labor analgesia. Anesth Analg. BeilinY HalpernS 2010 Ropivacaine versus bupivacaine for epidural labor analgesia Anesth Analg 10.1213/ANE.0b013e3181e3a08e20529986 Search in Google Scholar

[23] Scott DA, Charnley DM, Mooney PH, Deam RK, Mark AH. Epidural Ropivacaine Infusion for Postoperative Analgesia After Major Lower Abdominal Surgery-A Dose Finding Study [Internet]. Available from: https://journals.lww.com/anesthesia-analgesia. ScottDA CharnleyDM MooneyPH DeamRK MarkAH Epidural Ropivacaine Infusion for Postoperative Analgesia After Major Lower Abdominal Surgery-A Dose Finding Study [Internet] Available from: https://journals.lww.com/anesthesia-analgesia. Search in Google Scholar

[24] Schug SA, Scott DA, Payne J, Mooney PH, Hägglöf B. (1996). Postoperative analgesia by continuous extradural infusion of ropivacaine after upper abdominal surgery †. British Journal of Anaesthesia, 76. SchugSA ScottDA PayneJ MooneyPH HägglöfB 1996 Postoperative analgesia by continuous extradural infusion of ropivacaine after upper abdominal surgery † British Journal of Anaesthesia 76 10.1093/bja/76.4.4878652317 Search in Google Scholar

[25] Shatil B, Smiley R. (2020). Neuraxial analgesia for labour. BJA Educ., 20(3), 96–102. doi: 10.1016/j.bjae.2019.11.006. Epub 2020 Jan 27. Erratum in: BJA Educ. 2020 Jul;20(7):250. ShatilB SmileyR 2020 Neuraxial analgesia for labour BJA Educ. 20 3 96 102 10.1016/j.bjae.2019.11.006 Epub 2020 Jan 27. Erratum in: BJA Educ. 2020 Jul;20(7):250. 780809733456936 Open DOISearch in Google Scholar