<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background and aims</h3>
<p>For the prevention of PONV, we evaluated the efficacy of palonosetron compared with ondansetron along with dexamethasone in patients undergoing laparoscopic gynaecological surgery.</p>
</sec>
<sec><h3>Methods</h3>
<p>A total of 84 adults, posted for elective laparoscopic surgeries under general anaesthesia were included in the study. The patients were randomly allocated to two groups (n = 42 each). Immediately after induction, patients in the first group (group I) received 4 mg ondansetron with 8 mg dexamethasone, and patients in the second group (group II) received 0.075 mg palonosetron. Any incidences of nausea and/or vomiting, the requirement of rescue antiemetic, and side effects were recorded.</p>
</sec>
<sec><h3>Results</h3>
<p>In group I, 66.67% of the patients had an Apfel score of 2, and 33.33% of the patients had a score of 3. In group II, 85.71% of patients had an Apfel score of 2, and 14.29% of the patients had a score of 3. At 1, 4, and 8 hours, the incidence of PONV was comparable in both groups. At 24 hours there was a significant difference in the incidence of PONV in the group treated with ondansetron with dexamethasone combination (4/42) when compared to the palonosetron group (0/42). The overall incidence of PONV was significantly higher in group I (23.81%: ondansetron and dexamethasone combination) than in group II (7.14%: palonosetron). The need for rescue medication in group I was significantly high. Conclusion: Palonosetron was more efficacious compared to the combination of ondansetron and dexamethasone for preventing PONV for laparoscopic gynaecological surgery.</p>
</sec>
</abstract>

Background and aims
For the prevention of PONV, we evaluated the efficacy of palonosetron compared with ondansetron along with dexamethasone in patients undergoing laparoscopic gynaecological surgery.

Methods
A total of 84 adults, posted for elective laparoscopic surgeries under general anaesthesia were included in the study. The patients were randomly allocated to two groups (n = 42 each). Immediately after induction, patients in the first group (group I) received 4 mg ondansetron with 8 mg dexamethasone, and patients in the second group (group II) received 0.075 mg palonosetron. Any incidences of nausea and/or vomiting, the requirement of rescue antiemetic, and side effects were recorded.

Results
In group I, 66.67% of the patients had an Apfel score of 2, and 33.33% of the patients had a score of 3. In group II, 85.71% of patients had an Apfel score of 2, and 14.29% of the patients had a score of 3. At 1, 4, and 8 hours, the incidence of PONV was comparable in both groups. At 24 hours there was a significant difference in the incidence of PONV in the group treated with ondansetron with dexamethasone combination (4/42) when compared to the palonosetron group (0/42). The overall incidence of PONV was significantly higher in group I (23.81%: ondansetron and dexamethasone combination) than in group II (7.14%: palonosetron). The need for rescue medication in group I was significantly high. Conclusion: Palonosetron was more efficacious compared to the combination of ondansetron and dexamethasone for preventing PONV for laparoscopic gynaecological surgery.

Antiemetic Efficacy of Palonosetron Compared with the Combination of Ondansetron and Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Gynaecological Surgery

Romanian Journal of Anaesthesia and Intensive Care

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Background and aims
For the prevention of PONV, we evaluated the efficacy of palonosetron compared with ondansetron along with dexamethasone in patients...

Rescue antiemetic	Group 1	Group 2	P value
Yes	8 (19.05%)	0 (0%)	0.0093
No	34 (80.95%)	42 (100%)
Total	42	42

Proposed procedure	Group 1	Group 2	Grand Total	P value
DHL (Diagnostic Hystero laparoscopy)	30	32	62	0.193
Laparoscopic Cystectomy	7	7	14
Laparoscopic Hysterectomy	1		1
Laparoscopic Tubal Occlusion	3	2	5
Laparoscopy	1		1
Total Laparoscopic Hysterectomy		1	1
Total	42	42	84

Apfel Score	Group 1		Group 2		Total	P value
2	31	73.80%	32	76.19%	63	0.992
3	11	26.20%	10	23.81%	21
Total	42	100.00%	42	100.00%	84

PONV Incidence	Group 1			Group 2			P value

	Nausea	Vomiting	Total PONV	Nausea	Vomiting	Total PONV
At 1 hour	0	0	0	0	0	0	1.000
At 4 hr	1 (2.38%)	1 (2.38%)	2 (4.76%)	0	0	0	0.1548
At 8 hr	1 (2.38%)	1 (2.38%)	2 (4.76%)	0	0	0	0.1548
At 24 hr	4 (9.52%)	0	4 (9.52%)	0	0	0	0.0416^#
At 24–48 hr	2 (4.76%)	0	2 (4.76%)	2 (4.76%)	1 (2.38%)	3 (7.14%)	0.6312
Total	8 (19.05%)	2 (4.76%)	10 (23.81%)	2 (4.76%)	1 (2.38%)	3 (7.14%)	0.0488

Antiemetic Efficacy of Palonosetron Compared with the Combination of Ondansetron and Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Gynaecological Surgery

Article Category: Original Article

Publié en ligne: 25 sept. 2022

Pages: 19 - 24

DOI: https://doi.org/10.2478/rjaic-2021-0003

Mots clés
postoperative nausea and vomiting (PONV), palonosetron, ondansetron, dexamethasone

© 2021 Samarjit Dey et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Need for Rescue antiemetic in both the groups

Distribution of proposed procedures

Comparison of the Apfel scores between the groups

Comparison of two groups in terms of PONV incidence

Antiemetic Efficacy of Palonosetron Compared with the Combination of Ondansetron and Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Gynaecological Surgery

Article Category: Original Article

Publié en ligne: 25 sept. 2022

Pages: 19 - 24

DOI: https://doi.org/10.2478/rjaic-2021-0003

Mots cléspostoperative nausea and vomiting (PONV), palonosetron, ondansetron, dexamethasone

© 2021 Samarjit Dey et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Need for Rescue antiemetic in both the groups

Distribution of proposed procedures

Comparison of the Apfel scores between the groups

Comparison of two groups in terms of PONV incidence

Mots clés
postoperative nausea and vomiting (PONV), palonosetron, ondansetron, dexamethasone