Patient survival after resection of skeletal metastases and endoprosthetic reconstruction: a nation-wide cohort study in a single oncological institution

Figure 1.

Cox regression analysis of patient survival for the subcohort of 32 patients with metastases, stratified into histopathological groups according to the 2013-SPRING survival prediction model

	B	SE	Exp(B)	95 % CI for Exp(B)		p-value
				Lower	Upper
Age [per year]	0.039	0.037	1.040	0.967	1.119	0.293
Gender [male = 1]	0.235	0.622	1.265	0.373	4.285	0.706
Slow-growing-mets (reference)						0.022*
Fast-growing mets	1.859	0.898	6.419	1.105	37.294	0.038*
Moderate-growing mets	0.436	1.014	1.547	0.212	11.289	0.667
Pathological fx or > 1 mets	-0.683	0.725	0.505	0.122	2.093	0.346
C-reactive protein [mg/L]	0.018	0.008	1.018	1.003	1.034	0.021*
Leukocyte count [109/L]	0.096	0.081	1.100	0.940	1.289	0.234
Hemoglobin [g/L]	0.027	0.029	1.027	0.971	1.087	0.348
Thrombocyte count [109/L]	0.000	0.005	1.000	0.989	1.011	0.980

Demographic characteristics, oncological stage and observed survival of patients stratified according to the histopathological diagnosis according to the 2013-SPRING survival prediction model

	Fast-growing metastases	Moderate-growing metastases	Slow-growing metastases	Sarcomas	Non-oncological patients
No. of subjects	12	11	9	73	39
Mean age [years]	63 ± 14	65 ± 10	64 ± 12	42 ± 21	53 ± 19
Gender [Female/Male]	6 / 6	2 / 9	8 / 1	39 / 34	20 / 19
Percentage of patients with pathological fracture or > 1 metastasis	75%	73%	44%	18%	0%
Patients alive 2 years after the operation †	25%	55%	88%	80%	100%
Patients alive 5 years after the operation ‡	10%	30%	83%	69%	97%
Implant removed within 2 years after the operation †	0%	9%	13%	9%	11%
Implant removed within 5 years after the operation ‡	10%	10%	17%	18%	19%

Cox regression analysis of patient survival for the cohort of 144 patients with tumor endoprosthetic reconstructions, stratified into histopathological groups according to the 2013-SPRING survival prediction model

	B	SE	Exp(B)	95 % CI for Exp(B)		p-value
				Lower	Upper
Age [per year]	0.021	0.010	1.021	1.002	1.041	0.031*
Gender [male = 1]	-0.410	0.304	0.664	0.366	1.205	0.178
Slow-growing-mets (reference)						0.002*
Fast-growing mets	1.709	0.674	5.522	1.473	20.703	0.011*
Moderate-growing mets	0.853	0.703	2.347	0.592	9.308	0.225
Sarcomas	0.831	0.661	2.296	0.629	8.378	0.208
Non-oncological patients	-1.315	0.964	0.269	0.041	1.776	0.173
Pathological fx or > 1 mets	1.032	0.350	2.809	1.414	5.587	0.003*