A retrospective evaluation of therapeutic efficacy and safety of chemoradiotherapy in older patients (aged ≥ 75 years) with limited-disease small cell lung cancer: insights from two institutions and review of the literature
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Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68: 394–424. doi: 10.3322/caac.21492BrayFFerlayJSoerjomataramISiegelRLTorreLAJemalAGlobal cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countriesCA Cancer J Clin20186839442410.3322/caac.21492Open DOISearch in Google Scholar
Govindan R, Page N, Morgensztern D, Read W, Tierney R, Vlahiotis A, et al. Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol 2006; 24: 4539–44. doi: 10.1200/JCO.2005.04.4859GovindanRPageNMorgenszternDReadWTierneyRVlahiotisAChanging epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results databaseJ Clin Oncol20062445394410.1200/JCO.2005.04.4859Open DOISearch in Google Scholar
Dómine M, Moran T, Isla D, Martí JL, Sullivan I, Provencio M, et al. SEOM clinical guidelines for the treatment of small-cell lung cancer (SCLC) (2019). Clin Transl Oncol 2020; 22: 245–55. doi: 10.1007/s12094-020-02295-wDómineMMoranTIslaDMartíJLSullivanIProvencioMSEOM clinical guidelines for the treatment of small-cell lung cancer (SCLC) (2019)Clin Transl Oncol2020222455510.1007/s12094-020-02295-wOpen DOISearch in Google Scholar
Sekine I, Yamamoto N, Kunitoh H, Ohe Y, Tamura T, Kodama T, Saijo N. Treatment of small cell lung cancer in the elderly based on a critical literature review of clinical trials. Cancer Treat Rev 2004; 30: 359–68. doi: 10.1016/j.ctrv.2003.12.006SekineIYamamotoNKunitohHOheYTamuraTKodamaTSaijoNTreatment of small cell lung cancer in the elderly based on a critical literature review of clinical trialsCancer Treat Rev2004303596810.1016/j.ctrv.2003.12.006Open DOISearch in Google Scholar
Morita T. A statistical study of lung cancer in the annual of pathological autopsy cases in Japan, from 1958 to 1997, with reference to time trends of lung cancer in the world. Jpn J Cancer Res 2002; 93: 15–23. doi: 10.1111/j.1349-7006.2002.tb01195.xMoritaTA statistical study of lung cancer in the annual of pathological autopsy cases in Japan, from 1958 to 1997, with reference to time trends of lung cancer in the worldJpn J Cancer Res200293152310.1111/j.1349-7006.2002.tb01195.xOpen DOISearch in Google Scholar
Pallis AG, Shepherd FA, Lacombe D, Gridelli C. Treatment of small-cell lung cancer in elderly patients. Cancer 2010; 116: 1192–200. doi: 10.1002/cncr.24833PallisAGShepherdFALacombeDGridelliCTreatment of small-cell lung cancer in elderly patientsCancer2010116119220010.1002/cncr.24833Open DOISearch in Google Scholar
National Comprehensive Cancer Network clinical practice guidelines in oncology (NCCN Guidelines®). Small cell lung cancer. [internet]. 2023. [cited 2023 Oct 9]. Available at: https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1462National Comprehensive Cancer Network clinical practice guidelines in oncology (NCCN Guidelines®)Small cell lung cancer. [internet]2023[cited 2023 Oct 9]. Available at: https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1462Search in Google Scholar
Dingemans AC, Früh M, Ardizzoni A, Besse B, Faivre-Finn C, Hendriks LE, et al. Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2021; 32: 839–53. doi: 10.1016/j.annonc.2021.03.207DingemansACFrühMArdizzoniABesseBFaivre-FinnCHendriksLESmall-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upAnn Oncol2021328395310.1016/j.annonc.2021.03.207Open DOISearch in Google Scholar
Sekine I, Fukuda H, Kunitoh H, Saijo N. Cancer chemotherapy in the elderly. Jpn J Clin Oncol 1998; 28: 463–73. doi: 10.1093/jjco/28.8.463SekineIFukudaHKunitohHSaijoNCancer chemotherapy in the elderlyJpn J Clin Oncol1998284637310.1093/jjco/28.8.463Open DOISearch in Google Scholar
Talarico L, Chen G, Pazdur R. Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration. J Clin Oncol 2004; 22: 4626–31. doi: 10.1200/JCO.2004.02.175TalaricoLChenGPazdurREnrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug AdministrationJ Clin Oncol20042246263110.1200/JCO.2004.02.175Open DOISearch in Google Scholar
Takada M, Fukuoka M, Kawahara M, Sugiura T, Yokoyama A, Yokota S, et al. Phase III study of concurrent versus sequential thoracic radiotherapy in combination with cisplatin and etoposide for limited-stage small-cell lung cancer: results of the Japan Clinical Oncology Group Study 9104. J Clin Oncol 2002; 20: 3054–60. doi: 10.1200/JCO.2002.12.071TakadaMFukuokaMKawaharaMSugiuraTYokoyamaAYokotaSPhase III study of concurrent versus sequential thoracic radiotherapy in combination with cisplatin and etoposide for limited-stage small-cell lung cancer: results of the Japan Clinical Oncology Group Study 9104J Clin Oncol20022030546010.1200/JCO.2002.12.071Open DOISearch in Google Scholar
Yuen AR, Zou G, Turrisi AT, Sause W, Komaki R, Wagner H, et al. Similar outcome of elderly patients in intergroup trial 0096. Cancer 2000; 89: 1953–60. doi: 10.1002/1097-0142(20001101)89:9<1953::AID-CNCR11>3.3.CO;2-YYuenARZouGTurrisiATSauseWKomakiRWagnerHSimilar outcome of elderly patients in intergroup trial 0096Cancer20008919536010.1002/1097-0142(20001101)89:9<1953::AID-CNCR11>3.3.CO;2-YOpen DOISearch in Google Scholar
Schild SE, Stella PJ, Brooks BJ, Mandrekar S, Bonner JA, McGinnis WL, et al. Results of combined-modality therapy for limited-stage small cell lung carcinoma in the elderly. Cancer 2005; 103: 2349–54. doi: 10.1002/cncr.21034SchildSEStellaPJBrooksBJMandrekarSBonnerJAMcGinnisWLResults of combined-modality therapy for limited-stage small cell lung carcinoma in the elderlyCancer200510323495410.1002/cncr.21034Open DOISearch in Google Scholar
Goldstraw P, Crowley J, Chansky K, Giroux DJ, Groome PA, Rami-Porta R, et al. The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol 2007; 2: 706–14. doi: 10.1097/JTO.0b013e31812f3c1aGoldstrawPCrowleyJChanskyKGirouxDJGroomePARami-PortaRThe IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumoursJ Thorac Oncol200727061410.1097/JTO.0b013e31812f3c1aOpen DOISearch in Google Scholar
Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, et al. New response evaluation criteria in solid tumours: revised RECIST guideline. (version 1.1). Eur J Cancer 2009; 45: 228–47. doi: 10.1016/j.ejca.2008.10.026EisenhauerEATherassePBogaertsJSchwartzLHSargentDFordRNew response evaluation criteria in solid tumours: revised RECIST guideline. (version 1.1)Eur J Cancer2009452284710.1016/j.ejca.2008.10.026Open DOISearch in Google Scholar
Gridelli C, Casaluce F, Sgambato A, Monaco F, Guida C. Treatment of limited-stage small cell lung cancer in the elderly, chemotherapy vs. sequential chemoradiotherapy vs. concurrent chemoradiotherapy: that’s the question. Transl Lung Cancer Res 2016; 5: 150–4. doi: 10.21037/tlcr.2016.03.03GridelliCCasaluceFSgambatoAMonacoFGuidaCTreatment of limited-stage small cell lung cancer in the elderly, chemotherapy vs. sequential chemoradiotherapy vs. concurrent chemoradiotherapy: that’s the questionTransl Lung Cancer Res20165150410.21037/tlcr.2016.03.03Open DOISearch in Google Scholar
Jeremic B, Shibamoto Y, Acimovic L, Milisavljevic S. Carboplatin, etoposide, and accelerated hyperfractionated radiotherapy for elderly patients with limited small cell lung carcinoma: a phase II study. Cancer 1998; 82: 836–41. doi: 10.1002/(sici)1097-0142(19980301)82:5<836::aid-cncr6>3.0.co;2-hJeremicBShibamotoYAcimovicLMilisavljevicSCarboplatin, etoposide, and accelerated hyperfractionated radiotherapy for elderly patients with limited small cell lung carcinoma: a phase II studyCancer1998828364110.1002/(sici)1097-0142(19980301)82:5<836::aid-cncr6>3.0.co;2-hOpen DOISearch in Google Scholar
Shimizu T, Sekine I, Sumi M, Ito Y, Yamada K, Nokihara H, et al. Concurrent chemoradiotherapy for limited-disease small cell lung cancer in elderly patients aged 75 years or older. Jpn J Clin Oncol 2007; 37: 181–5. doi: 10.1093/jjco/hym005ShimizuTSekineISumiMItoYYamadaKNokiharaHConcurrent chemoradiotherapy for limited-disease small cell lung cancer in elderly patients aged 75 years or olderJpn J Clin Oncol200737181510.1093/jjco/hym005Open DOISearch in Google Scholar
Okamoto K, Okamoto I, Takezawa K, Tachibana I, Fukuoka M, Nishimura Y, et al. Cisplatin and etoposide chemotherapy combined with early concurrent twice-daily thoracic radiotherapy for limited-disease small cell lung cancer in elderly patients. Jpn J Clin Oncol 2010; 40: 54–9. doi: 10.1093/jjco/hyp137OkamotoKOkamotoITakezawaKTachibanaIFukuokaMNishimuraYCisplatin and etoposide chemotherapy combined with early concurrent twice-daily thoracic radiotherapy for limited-disease small cell lung cancer in elderly patientsJpn J Clin Oncol20104054910.1093/jjco/hyp137Open DOISearch in Google Scholar
Shukuya T, Takahashi T, Harada H, Ono A, Akamatsu H, Taira T, et al. Chemoradiotherapy for limited-disease small-cell lung cancer in elderly patients aged 75 years or older. Jpn J Clin Oncol 2013; 43: 176–83. doi: 10.1093/jjco/hys197ShukuyaTTakahashiTHaradaHOnoAAkamatsuHTairaTChemoradiotherapy for limited-disease small-cell lung cancer in elderly patients aged 75 years or olderJpn J Clin Oncol2013431768310.1093/jjco/hys197Open DOISearch in Google Scholar
Okamoto K, Okamoto I, Takeda M, Kobayashi S, Takeda K, Nakamatsu K, et al. A phase I study of split-dose cisplatin and etoposide with concurrent accelerated hyperfractionated thoracic radiotherapy in elderly patients with limited-disease small cell lung cancer. Jpn J Clin Oncol 2014; 44: 743–8. doi: 10.1093/jjco/hyu071OkamotoKOkamotoITakedaMKobayashiSTakedaKNakamatsuKA phase I study of split-dose cisplatin and etoposide with concurrent accelerated hyperfractionated thoracic radiotherapy in elderly patients with limited-disease small cell lung cancerJpn J Clin Oncol201444743810.1093/jjco/hyu071Open DOISearch in Google Scholar
Corso CD, Rutter CE, Park HS, Lester-Coll NH, Kim AW, Wilson LD, et al. Role of chemoradiotherapy in elderly patients with limited-stage small-cell lung cancer. J Clin Oncol 2015; 33: 4240–6. doi: 10.1200/JCO.2015.62.4270CorsoCDRutterCEParkHSLester-CollNHKimAWWilsonLDRole of chemoradiotherapy in elderly patients with limited-stage small-cell lung cancerJ Clin Oncol2015334240610.1200/JCO.2015.62.4270Open DOISearch in Google Scholar
Kubo T, Fujiwara K, Hotta K, Okada T, Kuyama S, Harita S, et al. A phase II study of topotecan and cisplatin with sequential thoracic radiotherapy in elderly patients with small-cell lung cancer: Okayama Lung Cancer Study Group 0102. Cancer Chemother Pharmacol 2016; 78: 769–74. doi: 10.1007/s00280-016-3135-2KuboTFujiwaraKHottaKOkadaTKuyamaSHaritaSA phase II study of topotecan and cisplatin with sequential thoracic radiotherapy in elderly patients with small-cell lung cancer: Okayama Lung Cancer Study Group 0102Cancer Chemother Pharmacol2016787697410.1007/s00280-016-3135-2Open DOISearch in Google Scholar
Misumi Y, Okamoto H, Sasaki J, Masuda N, Ishii M, Shimokawa T, et al. Phase I/II study of induction chemotherapy using carboplatin plus irinotecan and sequential thoracic radiotherapy (TRT) for elderly patients with limited-disease small-cell lung cancer (LD-SCLC): TORG 0604. BMC Cancer 2017; 17: 377. doi: 10.1186/s12885-017-3353-yMisumiYOkamotoHSasakiJMasudaNIshiiMShimokawaTPhase I/II study of induction chemotherapy using carboplatin plus irinotecan and sequential thoracic radiotherapy (TRT) for elderly patients with limited-disease small-cell lung cancer (LD-SCLC): TORG 0604BMC Cancer20171737710.1186/s12885-017-3353-yOpen DOISearch in Google Scholar
Stinchcombe TE, Fan W, Schild SE, Vokes EE, Bogart J, Le QT, et al. A pooled analysis of individual patient data from National Clinical Trials Network clinical trials of concurrent chemoradiotherapy for limited-stage small cell lung cancer in elderly patients versus younger patients. Cancer 2019; 125: 382–90. doi: 10.1002/cncr.31813StinchcombeTEFanWSchildSEVokesEEBogartJLeQTA pooled analysis of individual patient data from National Clinical Trials Network clinical trials of concurrent chemoradiotherapy for limited-stage small cell lung cancer in elderly patients versus younger patientsCancer20191253829010.1002/cncr.31813Open DOISearch in Google Scholar
Christodoulou M, Blackhall F, Mistry H, Leylek A, Knegjens J, Remouchamps V, et al. Compliance and outcome of elderly patients treated in the concurrent Once-Daily versus Twice-Daily radiotherapy (CONVERT) trial. J Thorac Oncol 2019; 14: 63–71. doi: 10.1016/j.jtho.2018.09.027ChristodoulouMBlackhallFMistryHLeylekAKnegjensJRemouchampsVCompliance and outcome of elderly patients treated in the concurrent Once-Daily versus Twice-Daily radiotherapy (CONVERT) trialJ Thorac Oncol201914637110.1016/j.jtho.2018.09.027Open DOISearch in Google Scholar
Killingberg KT, Grønberg BH, Slaaen M, Kirkevold Ø, Halvorsen TO. Treatment outcomes of older participants in a randomized trial comparing two schedules of twice-daily thoracic radiotherapy in limited-stage SCLC. J Thorac Oncol 2023; 18: 803–12. doi: 10.1016/j.jtho.2023.01.012KillingbergKTGrønbergBHSlaaenMKirkevoldØHalvorsenTOTreatment outcomes of older participants in a randomized trial comparing two schedules of twice-daily thoracic radiotherapy in limited-stage SCLCJ Thorac Oncol2023188031210.1016/j.jtho.2023.01.012Open DOISearch in Google Scholar
Smith TJ, Bohlke K, Lyman GH, Carson KR, Crawford J, Cross SJ, et al. Recommendations for the use of WBC growth factors: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol 2015; 33: 3199–212. doi:10.1200/JCO.2015.62.3488SmithTJBohlkeKLymanGHCarsonKRCrawfordJCrossSJRecommendations for the use of WBC growth factors: American Society of Clinical Oncology Clinical Practice Guideline UpdateJ Clin Oncol201533319921210.1200/JCO.2015.62.3488Open DOISearch in Google Scholar
Crawford J, Caserta C, Roila F, Group EGW. Hematopoietic growth factors: ESMO Clinical Practice Guidelines for the applications. Ann Oncol 2010; 21(Suppl 5): v248–51. doi: 10.1093/annonc/mdq195CrawfordJCasertaCRoilaFGroupEGWHematopoietic growth factors: ESMO Clinical Practice Guidelines for the applicationsAnn Oncol201021Suppl 5v2485110.1093/annonc/mdq195Open DOISearch in Google Scholar
Fujiwara T, Kenmotsu H, Naito T, Kawamura T, Mamesaya N, Kotake M, et al. The incidence and risk factors of febrile neutropenia in chemotherapy-naïve lung cancer patients receiving etoposide plus platinum. Cancer Chemother Pharmacol 2017; 79: 1229–37. doi: 10.1007/s00280-017-3324-7FujiwaraTKenmotsuHNaitoTKawamuraTMamesayaNKotakeMThe incidence and risk factors of febrile neutropenia in chemotherapy-naïve lung cancer patients receiving etoposide plus platinumCancer Chemother Pharmacol20177912293710.1007/s00280-017-3324-7Open DOISearch in Google Scholar
Kies MS, Mira JG, Crowley JJ, Chen TT, Pazdur R, Grozea PN, et al. Multimodal therapy for limited small-cell lung cancer: a randomized study of induction combination chemotherapy with or without thoracic radiation in complete responders; and with wide-field versus reduced-field radiation in partial responders: a Southwest Oncology Group Study. J Clin Oncol 1987; 5: 592–600. doi: 10.1200/JCO.1987.5.4.592KiesMSMiraJGCrowleyJJChenTTPazdurRGrozeaPNMultimodal therapy for limited small-cell lung cancer: a randomized study of induction combination chemotherapy with or without thoracic radiation in complete responders; and with wide-field versus reduced-field radiation in partial responders: a Southwest Oncology Group StudyJ Clin Oncol1987559260010.1200/JCO.1987.5.4.592Open DOISearch in Google Scholar
Oshita F, Kurata T, Kasai T, Fakuda M, Yamamoto N, Ohe Y, et al. Prospective evaluation of the feasibility of cisplatin-based chemotherapy for elderly lung cancer patients with normal organ functions. Jpn J Cancer Res 1995; 86: 1198–202. doi: 10.1111/j.1349-7006.1995.tb03315.xOshitaFKurataTKasaiTFakudaMYamamotoNOheYProspective evaluation of the feasibility of cisplatin-based chemotherapy for elderly lung cancer patients with normal organ functionsJpn J Cancer Res199586119820210.1111/j.1349-7006.1995.tb03315.xOpen DOISearch in Google Scholar
Rossi A, Di Maio M, Chiodini P, Rudd RM, Okamoto H, Skarlos DV, et al. Carboplatin- or cisplatin-based chemotherapy in first-line treatment of small-cell lung cancer: the COCIS meta-analysis of individual patient data. J Clin Oncol 2012; 30: 1692–8. doi: 10.1200/JCO.2011.40.4905RossiADi MaioMChiodiniPRuddRMOkamotoHSkarlosDVCarboplatin- or cisplatin-based chemotherapy in first-line treatment of small-cell lung cancer: the COCIS meta-analysis of individual patient dataJ Clin Oncol2012301692810.1200/JCO.2011.40.4905Open DOISearch in Google Scholar
Jara C, Gómez-Aldaraví JL, Tirado R, Meseguer VA, Alonso C, Fernández A. Small-cell lung cancer in the elderly--is age of patient a relevant factor? Acta Oncol 1999; 38: 781–6. doi: 10.1080/028418699432941JaraCGómez-AldaravíJLTiradoRMeseguerVAAlonsoCFernándezASmall-cell lung cancer in the elderly--is age of patient a relevant factor?Acta Oncol199938781610.1080/028418699432941Open DOISearch in Google Scholar
Kasahara N, Imai H, Kaira K, Mori K, Wakuda K, Ono A, et al. Clinical impact of post-progression survival on overall survival in patients with limited-stage disease small cell lung cancer after first-line chemoradiotherapy. Radiol Oncol 2015; 49: 409–15. doi: 10.1515/raon-2015-0037KasaharaNImaiHKairaKMoriKWakudaKOnoAClinical impact of post-progression survival on overall survival in patients with limited-stage disease small cell lung cancer after first-line chemoradiotherapyRadiol Oncol2015494091510.1515/raon-2015-0037Open DOISearch in Google Scholar