Assessment of chemical-shift and diffusion-weighted magnetic resonance imaging in differentiating malignant and benign vertebral lesions in oncologic patients. A single institution experience

1. Heindel W, Gübitz R, Vieth V, Weckesser M, Schober O, Schäfers M. The diagnostic imaging of bone metastases. Dtsch Arztebl Int 2014; 111: 741–47. doi: 10.3238/arztebl.2014.0741 HeindelW GübitzR ViethV WeckesserM SchoberO SchäfersM The diagnostic imaging of bone metastases Dtsch Arztebl Int 2014 111 741 47 10.3238/arztebl.2014.0741 Open DOISearch in Google Scholar

2. Chen WZ, Shen JF, Zhou Y, Chen XY, Liu JM, Liu ZL. Clinical characteristics and risk factors for developing bone metastases in patients with breast cancer. Sci Rep 2017; 7: 1325. doi: 10.1038/s41598-017-11700-4 ChenWZ ShenJF ZhouY ChenXY LiuJM LiuZL Clinical characteristics and risk factors for developing bone metastases in patients with breast cancer Sci Rep 2017 7 1325 10.1038/s41598-017-11700-4 Open DOISearch in Google Scholar

3. Soliman M, Taunk NK, Simons RE, Osborne JR, Kim MM, Szerlip NJ, et al. Anatomic and functional imaging in the diagnosis of spine metastases and response assessment after spine radiosurgery. Neurosurg Focus 2017; 42: E5. doi: 10.3171/2016.9.FOCUS16350 SolimanM TaunkNK SimonsRE OsborneJR KimMM SzerlipNJ Anatomic and functional imaging in the diagnosis of spine metastases and response assessment after spine radiosurgery Neurosurg Focus 2017 42 E5 10.3171/2016.9.FOCUS16350 Open DOISearch in Google Scholar

4. Oztekin O, Ozan E, Hilal Adibelli Z, Unal G, Abali Y. SSH-EPI diffusion-weighted MR imaging of the spine with low b values: is it useful in differentiating malignant metastatic tumor infiltration from benign fracture edema? Skeletal Radiology 2009; 38: 651–8. doi: 10.1007/s00256-009-0668-z OztekinO OzanE Hilal AdibelliZ UnalG AbaliY SSH-EPI diffusion-weighted MR imaging of the spine with low b values: is it useful in differentiating malignant metastatic tumor infiltration from benign fracture edema? Skeletal Radiology 2009 38 651 8 10.1007/s00256-009-0668-z Open DOISearch in Google Scholar

5. Shapiro CL. Osteoporosis: a long-term and late-effect of breast cancer treatments. Cancers 2020; 12: 3094. doi: 10.3390/cancers121130945 ShapiroCL Osteoporosis: a long-term and late-effect of breast cancer treatments Cancers 2020 12 3094 10.3390/cancers121130945 Open DOISearch in Google Scholar

6. Xiao Z, Li J, Li C, Zhang Y, She D, Cao D. Chemical shift MR imaging in the lumbar vertebra: the effect of field strength, scanner vendors and flip angles in repeatability of signal intensity index measurement. BMC Med Imaging 2016; 16: 64. doi: 10.1186/s12880-016-0167-3 XiaoZ LiJ LiC ZhangY SheD CaoD Chemical shift MR imaging in the lumbar vertebra: the effect of field strength, scanner vendors and flip angles in repeatability of signal intensity index measurement BMC Med Imaging 2016 16 64 10.1186/s12880-016-0167-3 Open DOISearch in Google Scholar

7. Ragab Y, Emad Y, Gheita T, Mansour M, Abou-Zeid A, Ferrari S, et al. Differentiation of osteoporotic and neoplastic vertebral fractures by chemical shift {in-phase and out-of phase} MR imaging. Eur J Radiol 2009; 72: 125–33. doi: 10.1016/j.ejrad.2008.06.019 RagabY EmadY GheitaT MansourM Abou-ZeidA FerrariS Differentiation of osteoporotic and neoplastic vertebral fractures by chemical shift {in-phase and out-of phase} MR imaging Eur J Radiol 2009 72 125 33 10.1016/j.ejrad.2008.06.019 Open DOISearch in Google Scholar

8. Dietrich O, Geith T, Reiser MF, Baur-Melnyk A. Diffusion imaging of the vertebral bone marrow. NMR Biomed 2017; 30: e333. doi: 10.1002/nbm.3333 DietrichO GeithT ReiserMF Baur-MelnykA Diffusion imaging of the vertebral bone marrow NMR Biomed 2017 30 e333 10.1002/nbm.3333 Open DOISearch in Google Scholar

9. Park HJ, Lee SY, Rho MH, Chung EC, Kim MS, Kwon HJ, et al. Single-shot echo-planar diffusion-weighted MR imaging at 3T and 1.5T for differentiation of benign vertebral fracture edema and tumor infiltration. Korean J Radiol 2016; 17: 590–7. doi: 10.3348/kjr.2016.17.5.590 ParkHJ LeeSY RhoMH ChungEC KimMS KwonHJ Single-shot echo-planar diffusion-weighted MR imaging at 3T and 1.5T for differentiation of benign vertebral fracture edema and tumor infiltration Korean J Radiol 2016 17 590 7 10.3348/kjr.2016.17.5.590 Open DOISearch in Google Scholar

10. Kwack KS, Lee HD, Jeon SW, Lee HY, Park S. Comparison of proton density fat fraction, simultaneous R2*, and apparent diffusion coefficient for assessment of focal vertebral bone marrow lesions. Clin Radiol 2020; 75: 123–30. doi: 10.1016/j.crad.2019.09.141 KwackKS LeeHD JeonSW LeeHY ParkS Comparison of proton density fat fraction, simultaneous R2*, and apparent diffusion coefficient for assessment of focal vertebral bone marrow lesions Clin Radiol 2020 75 123 30 10.1016/j.crad.2019.09.141 Open DOISearch in Google Scholar

11. Akman B, Ata Korkmaz HA, Sarı A. Efficacy of chemical shift MRI for differentiating diffuse red bone marrow reconversion and hematological malignancies. Turk J Med Sci 2019; 49: 644–52. doi: 10.3906/sag-1812-125 AkmanB Ata KorkmazHA SarıA Efficacy of chemical shift MRI for differentiating diffuse red bone marrow reconversion and hematological malignancies Turk J Med Sci 2019 49 644 52 10.3906/sag-1812-125 Open DOISearch in Google Scholar

12. Geith T, Schmidt G, Biffar A, Dietrich O, Duerr HR, Reiser M, et al. Quantitative evaluation of benign and malignant vertebral fractures with diffusion-weighted MRI: what is the optimum combination of b values for ADC-based lesion differentiation with the single-shot turbo spin-echo sequence? AJR Am J Roentgenol 2014; 203: 582–8. doi: 10.2214/AJR.13.11632 GeithT SchmidtG BiffarA DietrichO DuerrHR ReiserM Quantitative evaluation of benign and malignant vertebral fractures with diffusion-weighted MRI: what is the optimum combination of b values for ADC-based lesion differentiation with the single-shot turbo spin-echo sequence? AJR Am J Roentgenol 2014 203 582 8 10.2214/AJR.13.11632 Open DOISearch in Google Scholar

13. Schmeel FC, Lakghomi A, Lehnen NC, Haase R, Banat M, Wach J, et al. Proton density fat fraction spine MRI for differentiation of erosive vertebral endplate degeneration and infectious spondylitis. Diagnostics 2021; 12: 78. doi: 10.3390/diagnostics12010078 SchmeelFC LakghomiA LehnenNC HaaseR BanatM WachJ Proton density fat fraction spine MRI for differentiation of erosive vertebral endplate degeneration and infectious spondylitis Diagnostics 2021 12 78 10.3390/diagnostics12010078 Open DOISearch in Google Scholar

14. Soerjomataram I, Bray F. Planning for tomorrow: global cancer incidence and the role of prevention 2020–2070. Nat Rev Clin Oncol 2021; 18: 663–72. doi: 10.1038/s41571-021-00514-z SoerjomataramI BrayF Planning for tomorrow: global cancer incidence and the role of prevention 2020–2070 Nat Rev Clin Oncol 2021 18 663 72 10.1038/s41571-021-00514-z Open DOISearch in Google Scholar

15. Yang W, Pan Q, Huang F, Hu H, Shao Z. Research progress of bone metastases: from disease recognition to clinical practice. Front Oncol 2023; 12: 1105745. doi: 10.3389/fonc YangW PanQ HuangF HuH ShaoZ Research progress of bone metastases: from disease recognition to clinical practice Front Oncol 2023 12 1105745 10.3389/fonc Open DOISearch in Google Scholar

16. Disler DG, McCauley TR, Ratner LM, Kesack CD, Cooper JA. In-phase and out-of-phase MR imaging of bone marrow: prediction of neoplasia based on the detection of coexistent fat and water. AJR Am J Roentgenol 1997; 169: 1439–47. doi: 10.2214/ajr.169.5.9353477 DislerDG McCauleyTR RatnerLM KesackCD CooperJA In-phase and out-of-phase MR imaging of bone marrow: prediction of neoplasia based on the detection of coexistent fat and water AJR Am J Roentgenol 1997 169 1439 47 10.2214/ajr.169.5.9353477 Open DOISearch in Google Scholar

17. van Vucht N, Santiago R, Pressney I, Saifuddin A. Role of in-phase and out-of-phase chemical shift MRI in differentiation of non-neoplastic versus neoplastic benign and malignant marrow lesions. Br J Radiol 2021; 94: 20200710. doi: 10.1259/bjr.20200710 van VuchtN SantiagoR PressneyI SaifuddinA Role of in-phase and out-of-phase chemical shift MRI in differentiation of non-neoplastic versus neoplastic benign and malignant marrow lesions Br J Radiol 2021 94 20200710 10.1259/bjr.20200710 Open DOISearch in Google Scholar

18. Zajick DC Jr, Morrison WB, Schweitzer ME, Parellada JA, Carrino JA. Benign and malignant processes: normal values and differentiation with chemical shift MR imaging in vertebral marrow. Radiology 2005; 237: 590–6. doi: 10.1148/radiol.2372040990 ZajickDCJr MorrisonWB SchweitzerME ParelladaJA CarrinoJA Benign and malignant processes: normal values and differentiation with chemical shift MR imaging in vertebral marrow Radiology 2005 237 590 6 10.1148/radiol.2372040990 Open DOISearch in Google Scholar

19. Suh CH, Yun SJ, Jin W, Park SY, Ryu CW, Lee SH. Diagnostic performance of in-phase and opposed-phase chemical-shift imaging for differentiating benign and malignant vertebral marrow lesions: a meta-analysis. AJR Am J Roentgenol 2018; 211: W188–W197. doi: 10.2214/AJR.17.19306 SuhCH YunSJ JinW ParkSY RyuCW LeeSH Diagnostic performance of in-phase and opposed-phase chemical-shift imaging for differentiating benign and malignant vertebral marrow lesions: a meta-analysis AJR Am J Roentgenol 2018 211 W188 W197 10.2214/AJR.17.19306 Open DOISearch in Google Scholar

20. Luo Z, Litao L, Gu S, Luo X, Li D, Yu L, et al. Standard-b-value vs low-b-value DWI for differentiation of benign and malignant vertebral fractures: a meta-analysis. Br J Radiol 2016; 89: 20150384. doi: 10.1259/bjr.20150384 LuoZ LitaoL GuS LuoX LiD YuL Standard-b-value vs low-b-value DWI for differentiation of benign and malignant vertebral fractures: a meta-analysis Br J Radiol 2016 89 20150384 10.1259/bjr.20150384 Open DOISearch in Google Scholar

21. Biffar A, Dietrich O, Sourbron S, Duerr HR, Reiser MF, Baur-Melnyk A. Diffusion and perfusion imaging of bone marrow. Eur J Radiol 2010; 76: 323–8. doi: 10.1016/j.ejrad.2010.03.011 BiffarA DietrichO SourbronS DuerrHR ReiserMF Baur-MelnykA Diffusion and perfusion imaging of bone marrow Eur J Radiol 2010 76 323 8 10.1016/j.ejrad.2010.03.011 Open DOISearch in Google Scholar

22. Mourad C, Cosentino A, Nicod Lalonde M, Omoumi P. Advances in bone marrow imaging: strengths and limitations from a clinical perspective. Semin Musculoskelet Radiol 2023; 27: 3–21. doi: 10.1055/s-0043-1761612 MouradC CosentinoA Nicod LalondeM OmoumiP Advances in bone marrow imaging: strengths and limitations from a clinical perspective Semin Musculoskelet Radiol 2023 27 3 21 10.1055/s-0043-1761612 Open DOISearch in Google Scholar

23. Park S, Kwack KS, Chung NS, Hwang J, Lee HY, Kim JH. Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging of focal vertebral bone marrow lesions: initial experience of the differentiation of nodular hyperplastic hematopoietic bone marrow from malignant lesions. Skeletal Radiol 2017; 46: 675–83. doi: 10.1007/s00256-017-2603-z ParkS KwackKS ChungNS HwangJ LeeHY KimJH Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging of focal vertebral bone marrow lesions: initial experience of the differentiation of nodular hyperplastic hematopoietic bone marrow from malignant lesions Skeletal Radiol 2017 46 675 83 10.1007/s00256-017-2603-z Open DOISearch in Google Scholar

24. Dumont RA, Keen NN, Bloomer CW, Schwartz BS, Talbott J, Clark AJ, et al. Clinical utility of diffusion-weighted imaging in spinal infections. Clin Neuroradiol 2019; 29: 515–22. doi: 10.1007/s00062-018-0681-5 DumontRA KeenNN BloomerCW SchwartzBS TalbottJ ClarkAJ Clinical utility of diffusion-weighted imaging in spinal infections Clin Neuroradiol 2019 29 515 22 10.1007/s00062-018-0681-5 Open DOISearch in Google Scholar

25. Maeda M, Sakuma H, Maier SE, Takeda K. Quantitative assessment of diffusion abnormalities in benign and malignant vertebral compression fractures by line scan diffusion-weighted imaging. AJR Am J Roentgenol 2003; 181: 1203–9. doi: 10.2214/ajr MaedaM SakumaH MaierSE TakedaK Quantitative assessment of diffusion abnormalities in benign and malignant vertebral compression fractures by line scan diffusion-weighted imaging AJR Am J Roentgenol 2003 181 1203 9 10.2214/ajr Open DOISearch in Google Scholar

26. Suh CH, Yun SJ, Jin W, Lee SH, Park SY, Ryu CW. ADC as a useful diagnostic tool for differentiating benign and malignant vertebral bone marrow lesions and compression fractures: a systematic review and meta-analysis. Eur Radiol 2018; 28: 2890–902. doi: 10.1007/s00330-018-5330-5 SuhCH YunSJ JinW LeeSH ParkSY RyuCW ADC as a useful diagnostic tool for differentiating benign and malignant vertebral bone marrow lesions and compression fractures: a systematic review and meta-analysis Eur Radiol 2018 28 2890 902 10.1007/s00330-018-5330-5 Open DOISearch in Google Scholar

27. Schmeel FC, Enkirch SJ, Luetkens JA, Faron A, Lehnen N, Sprinkart AM, et al. Diagnostic accuracy of quantitative imaging biomarkers in the differentiation of benign and malignant vertebral lesions: combination of diffusion-weighted and proton density fat fraction spine MRI. Clin Neuroradiol 2021; 31: 1059–70. doi: 10.1007/s00062-021-01009-1 SchmeelFC EnkirchSJ LuetkensJA FaronA LehnenN SprinkartAM Diagnostic accuracy of quantitative imaging biomarkers in the differentiation of benign and malignant vertebral lesions: combination of diffusion-weighted and proton density fat fraction spine MRI Clin Neuroradiol 2021 31 1059 70 10.1007/s00062-021-01009-1 Open DOISearch in Google Scholar

28. Tsujikawa T, Oikawa H, Tasaki T, Hosono N, Tsuyoshi H, Yoshida Y, et al. Whole-body bone marrow DWI correlates with age, anemia, and hematopoietic activity. Eur J Radiol 2019; 118: 223–30. doi: 10.1016/j.ejrad.2019.07.022 TsujikawaT OikawaH TasakiT HosonoN TsuyoshiH YoshidaY Whole-body bone marrow DWI correlates with age, anemia, and hematopoietic activity Eur J Radiol 2019 118 223 30 10.1016/j.ejrad.2019.07.022 Open DOISearch in Google Scholar

29. Pozzi G, Albano D, Messina C, Angileri SA, Al-Mnayyis A, Galbusera F, et al. Solid bone tumors of the spine: diagnostic performance of apparent diffusion coefficient measured using diffusion-weighted MRI using histology as a reference standard. J Magn Reson Imaging 2018; 47: 1034–42. doi: 10.1002/jmri.25826 PozziG AlbanoD MessinaC AngileriSA Al-MnayyisA GalbuseraF Solid bone tumors of the spine: diagnostic performance of apparent diffusion coefficient measured using diffusion-weighted MRI using histology as a reference standard J Magn Reson Imaging 2018 47 1034 42 10.1002/jmri.25826 Open DOISearch in Google Scholar

30. Hajalioghli P, Daghighi MH, Ghaffari J, Mirza-Aghazadeh-Attari M, Khamanian J, Ghaderi P, et al. Accuracy of diffusion-weighted imaging in discriminating atypical vertebral haemangiomas from malignant masses in patients with vertebral lesions: a cross-sectional study. Pol J Radiol 2020 6; 85: e340–e347. doi: 10.5114/pjr.2020.97602 HajalioghliP DaghighiMH GhaffariJ Mirza-Aghazadeh-AttariM KhamanianJ GhaderiP Accuracy of diffusion-weighted imaging in discriminating atypical vertebral haemangiomas from malignant masses in patients with vertebral lesions: a cross-sectional study Pol J Radiol 2020 6; 85 e340 e347 10.5114/pjr.2020.97602 Open DOISearch in Google Scholar

31. Lee JH, Park S. Differentiation of schmorl nodes from bone metastases of the spine: Use of apparent diffusion coefficient derived from DWI and fat fraction derived from a dixon sequence. AJR Am J Roentgenol 2019; 213: W228–W235. doi: 10.2214/AJR.18.21003 LeeJH ParkS Differentiation of schmorl nodes from bone metastases of the spine: Use of apparent diffusion coefficient derived from DWI and fat fraction derived from a dixon sequence AJR Am J Roentgenol 2019 213 W228 W235 10.2214/AJR.18.21003 Open DOISearch in Google Scholar