A | 2.15 (0.69–6.68) | 0.185 | 1.66 (0.50–5.47) | 0.408 |
B | 1.02 (0.28–3.76) | 0.976 | 0.92 (0.22–3.76) | 0.905 |
C | 1.69 (0.46–6.16) | 0.430 | 1.49 (0.40–5.48) | 0.551 |
Comparison B |
0.16 (0.03–1.01) | 0.052 | 0.23 (0.03–1.67) | 0.145 |
Comparison C |
1.01 (0.25–4.18) | 0.985 | 1.36 (0.31–5.92) | 0.682 |
Comparison C |
1.57 (0.26–9.58) | 0.624 | 2.16 (0.31–14.83) | 0.435 |
A | 1.20 (1.01–1.37) | 1.28 (1–1.39) | 0.576 |
B | 1.21 (1.05–1.37) | 1.28 (1.13–1.35) | 0.601 |
C | 1.29 (1.07–1.37) | 1.23 (1.02–1.34) | 0.369 |
Comparison B |
0.04 (−0.1 to 0.1) | −0.01 (−0.11 to 0.07) | 0.317 |
Comparison C |
0.01 (−0.09 to 0.22) | −0.04 (−0.16 to 0.15) | 0.241 |
Comparison C |
0.03 (−0.09 to 0.13) | −0.01 (−0.12 to 0.07) | 0.353 |
CC | 45 (56.3) | 215 (56.3) | 139 (46.8) | ||
CT | 28 (35.0) | 133 (34.8) | 140 (47.1) | ||
TT | 7 (8.8) | 34 (8.9) | 18 (6.1) | ||
CT+TT | 35 (43.8) | 167 (43.7) | 158 (53.2) | ||
CC | 17 (20.0) | 103 (26.8) | 93 (30.8) | Padd = 0.362 | |
CA | 48 (56.5) | 194 (50.4) | 147 (48.7) | ||
AA | 20 (23.5) | 88 (22.9) | 62 (20.5) | ||
CA+AA | 68 (80.0) | 282 (73.2) | 209 (69.2) | Pdom = 0.127 | |
CC | 48 (63.2) | 233 (61.0) | 160 (54.6) | Padd = 0.107 | |
CT | 26 (34.2) | 131 (34.3) | 107 (36.5) | ||
TT | 2 (2.6) | 18 (4.7) | 26 (8.9) | ||
CT+TT | 28 (36.8) | 149 (39.0) | 133 (45.4) | Pdom = 0.178 |
Gender | Male, N (%) | 555 (71.7) | 63 (73.3) | 269 (69.7) | 223 (73.8) | 0.467 |
Female, N (%) | 219 (28.3) | 23 (26.7) | 117 (30.3) | 79 (26.2) | ||
Age | Years, median (25%–75%) | 59.1 (51.1–67.5) | 53.3 (48.1–59.5) | 55.0 (48.8–62.7) | 66.0 (59.0–73.0) | |
Smoking | No, N (%) | 398 (52.0) [8] | 47 (54.7) | 189 (49.0) | 162 (55.1) | 0.254 |
Yes, N (%) | 368 (48.0) | 39 (45.3) | 197 (51.0) | 132 (44.9) |
Location [1] | Pleura | 267 (88,7) |
Peritoneum | 34 (11,3) | |
Histology type | Epithelioid | 227 (75,2) |
Biphasic | 27 (8,9) | |
Sarcomatoid | 27 (8,9) | |
Undifferentiated | 21 (6,9) | |
Stage (pleural MM) | 1 | 20 (7,5) |
2 | 65 (24,3) | |
3 | 89 (33,3) | |
4 | 93 (34,8) | |
ECOG performance status [1] | 0 | 18 (6,0) |
1 | 154 (51,2) | |
2 | 111 (36,9) | |
3 | 18 (6,0) | |
Asbestos exposure [8] | No | 79 (26,9) |
Yes | 215 (73,1) | |
Pain [29] | No | 114 (41,8) |
Yes | 159 (58,2) | |
Weight loss [34] | No | 97 (36,2) |
Yes | 171 (63,8) | |
CRP [mg/mL] [48] | Median (25%–75%) | 22 (7–63,5) |
Chemotherapy [21] | No chemotherapy | 17 (6.1) |
Gemcitabine with cisplatin | 161 (57.3) | |
Pemetrexed with cisplatin | 92 (31.6) | |
Other | 11 (3.9) | |
Chemotherapy response [46] | CR | 10 (3.9) |
PR | 73 (28.5) | |
SD | 128 (50.0) | |
PD | 45 (17.6) | |
Response rate | Poor response (SD+PD) | 173 (67.6) |
Good response (PR+CR) | 83 (32.4) |
A | 79 | 1.23 (1.01–1.37) | ||
B | 66 | 1.23 (1.10–1.38) | ||
C | 66 | 1.27 (1.08–1.36) | ||
Comparison B |
66 | 0.480 | 28 shortens | |
38 prolongs | ||||
Comparison C |
66 | 0.423 | 32 shortens | |
34 prolongs | ||||
Comparison C |
53 | 0.733 | 26 shortens | |
27 prolongs |
CC | 81 (68.6) | 37 (31.4) | Reference | Reference | |||
CT | 76 (65.5) | 40 (34.5) | 1.15 (0.67–1.99) | 0.611 | 1.20 (0.67–2.16) | 0.542 | |
TT | 11 (64.7) | 6 (35.3) | 1.19 (0.41–3.47) | 0.745 | 1.27 (9.42–3.87) | 0.671 | |
CT+TT | 87 (65.4) | 46 (34.6) | 1.16 (0.68–1.96) | 0.587 | 1.21 (0.69–2.14) | 0.511 | |
CC | 53 (67.1) | 26 (32.9) | Reference | Reference | |||
CA | 89 (70.6) | 37 (29.4) | 0.85 (0.46–1.55) | 0.592 | 0.85 (0.45–1.63) | 0.625 | |
AA | 31 (60.8) | 20 (39.2) | 1.32 (0.63–2.74) | 0.463 | 1.16 (0.53–2.57) | 0.709 | |
CA+AA | 120 (67.8) | 57 (32.2) | 0.97 (0.55–1.70) | 0.911 | 0.94 (0.51–1.71) | 0.831 | |
CC | 94(72.9) | 35 (27.1) | Reference | Reference | |||
CT | 58 (59.8) | 39 (40.2) | 1.81 (1.03–3.17) | 2.08 (1.13–3.84) | |||
TT | 14 (66.7) | 7 (33.3) | 1.34 (0.50–3.60) | 0.558 | 1.85 (0.64–5.31) | 0.255 | |
CT+TT | 72 (61.0) | 46 (39.0) | 1.72 (1.00–2.93) | 2.04 (1.13–3.67) |
CC | 10.2 (6.5–18.9) | Reference | Reference | |||
CT | 9.4 (6.1–14.5) | 1.21 (0.93–1.57) | 0.163 | 1.31 (0.98–1.76) | 0.073 | |
TT | 10.0 (6.6–14.2) | 1.32 (0.79–2.20) | 0.294 | 1.46 (0.82–2.59) | 0.194 | |
CT+TT | 9.7 (6.3–14.3) | 1.22 (0.95–1.57) | 0.127 | 1.33 (1.00–1.77) | 0.051 | |
CC | 9.4 (5.9–13.4) | Reference | Reference | |||
CA | 9.7 (6.4–14.9) | 0.98 (0.74–1.30) | 0.879 | 0.83 (0.60–1.14) | 0.250 | |
AA | 12.2 (7.1–20.1) | 0.68 (0.47–0.98) | 0.68 (0.45–1.03) | 0.070 | ||
CA+AA | 10.2 (6.5–17.6) | 0.87 (0.67–1.15) | 0.328 | 0.78 (0.57–1.06) | 0.113 | |
CC | 10.7 (6.3–16.5) | Reference | Reference | |||
CT | 9.3 (6.1–15.0) | 1.09 (0.83–1.42) | 0.552 | 1.06 (0.79–1.43) | 0.699 | |
TT | 11.8 (7.3–13.4) | 0.85 (0.52–1.38) | 0.502 | 0.81 (0.48–1.38) | 0.443 | |
CT+TT | 9.4 (6.6–15.0) | 1.04 (0.80–1.34) | 0.791 | 1.01 (0.76–1.33) | 0.963 |
CC | 18.2 (10.1–28.6) | Reference | Reference | |||
CT | 19.3 (9.6–31.4) | 1.01 (0.76–1.35) | 0.944 | 1.02 (0.75–1.39) | 0.899 | |
TT | 24.4 (22.0–31.1) | 0.84 (0.46–1.54) | 0.573 | 0.94 (0.48–1.83) | 0.859 | |
CT+TT | 20.3 (9.9–31.2) | 0.99 (0.75–1.31) | 0.924 | 1.01 (0.75–1.36) | 0.945 | |
CC | 17.5 (11.6–28.1) | Reference | Reference | |||
CA | 19.3 (10.7–32.5) | 0.87 (0.64–1.20) | 0.404 | 0.88 (0.62–1.24) | 0.460 | |
AA | 20.6 (9.6–31.4) | 0.79 (0.53–1.17) | 0.229 | 0.86 (0.56–1.31) | 0.478 | |
CA+AA | 19.5 (10.0–32.5) | 0.85 (0.63–1.14) | 0.270 | 0.87 (0.63–1.21) | 0.410 | |
CC | 20.3 (9.6–31.4) | Reference | Reference | |||
CT | 19.3 (11.1–25.9) | 1.09 (0.81–1.47) | 0.578 | 1.13 (0.82–1.55) | 0.455 | |
TT | 16.0 (13.1–29.0) | 1.01 (0.60–1.72) | 0.958 | 0.74 (0.41–1.35) | 0.321 | |
CT+TT | 18.5 (11.4–29.0) | 1.08 (0.81–1.43) | 0.619 | 1.04 (0.77–1.41) | 0.780 |
CC | 139 (46.8) | 260 (56.3) | Reference | Reference | |||
CT | 140 (47.1) | 161 (34.8) | 1.63 (1.20–2.21) | 1.49 (1.06–2.10) | |||
TT | 18 (6.1) | 41 (8.9) | 0.82 (0.46–1.48) | 0.514 | 0.78 (0.40–1.54) | 0.470 | |
CT+TT | 158 (53.2) | 202 (43.7) | 1.46 (1.09–1.96) | 1.36 (0.98–1.88) | 0.070 | ||
CC | 93 (30.8) | 120 (56.3) | Reference | Reference | |||
CA | 147 (48.7) | 242 (51.5) | 0.78 (0.56–1.10) | 0.160 | 0.71 (0.48–1.04) | 0.076 | |
AA | 62 (20.5) | 108 (23.0) | 0.74 (0.49–1.12) | 0.155 | 0.56 (0.35–0.90) | ||
CA+AA | 209 (69.2) | 350 (74.5) | 0.77 (0.56–1.06) | 0.111 | 0.66 (0.46–0.95) | ||
CC | 160 (54.6) | 281 (61.4) | Reference | Reference | |||
CT | 107 (36.5) | 157 (34.3) | 1.20 (0.88–1.64) | 0.261 | 1.41 (0.99–2.01) | 0.058 | |
TT | 26 (8.9) | 20 (4.4) | 2.28 (1.24–4.22) | 2.22 (1.10–4.48) | |||
CT+TT | 133 (45.4) | 177 (38.6) | 1.32 (0.98–1.78) | 0.067 | 1.52 (1.08–2.12) |
CC | Reference | Reference | |||
CT | 1.63 (1.18–2.24) | 1.52 (1.06–2.16) | |||
TT | 0.82 (0.45–1.51) | 0.521 | 0.76 (0.38–1.53) | 0.445 | |
CT+TT | 1.46 (1.08–1.99) | 1.37 (0.98–1.93) | 0.069 | ||
CC | Reference | Reference | |||
CA | 0.84 (0.59–1.19) | 0.330 | 0.77 (0.52–1.15) | 0.196 | |
AA | 0.78 (0.51–1.20) | 0.257 | 0.58 (0.36–0.94) | ||
CA+AA | 0.82 (0.59–1.15) | 0.245 | 0.71 (0.48–1.03) | 0.070 | |
CC | Reference | Reference | |||
CT | 1.19 (0.86–1.65) | 0.296 | 1.39 (0.96–2.01) | 0.078 | |
TT | 2.10 (1.12–3.96) | 2.11 (1.02–4.34) | |||
CT+TT | 1.30 (0.96–1.78) | 0.096 | 1.48 (1.05–2.10) |