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Dosimetric comparison of postoperative interstitial high-dose-rate brachytherapy and modern external beam radiotherapy modalities in tongue and floor of the mouth tumours in terms of doses to critical organs

Örs Ferenczi

Örs Ferenczi

Centre of Radiotherapy, National Institute of OncologyBudapest, Hungary
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Ferenczi, Örs
, 
Tibor Major

Tibor Major

  • Centre of Radiotherapy, National Institute of OncologyBudapest, Hungary
  • Department of Oncology, Semmelweis UniversityBudapest, Hungary
  • National Tumour Biology Laboratory, National Institute of OncologyBudapest, Hungary
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Major, Tibor
, 
Georgina Fröhlich

Georgina Fröhlich

  • Centre of Radiotherapy, National Institute of OncologyBudapest, Hungary
  • Eötvös Loránd University, Faculty of ScienceBudapest, Hungary
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Fröhlich, Georgina
, 
Dalma Béla

Dalma Béla

Centre of Radiotherapy, National Institute of OncologyBudapest, Hungary
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Béla, Dalma
, 
Szabolcs Tódor

Szabolcs Tódor

Centre of Radiotherapy, National Institute of OncologyBudapest, Hungary
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Tódor, Szabolcs
, 
Csaba Polgár

Csaba Polgár

  • Centre of Radiotherapy, National Institute of OncologyBudapest, Hungary
  • Department of Oncology, Semmelweis UniversityBudapest, Hungary
  • National Tumour Biology Laboratory, National Institute of OncologyBudapest, Hungary
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Polgár, Csaba
, 
Hironori Akiyama

Hironori Akiyama

Department of Oral Radiology, Osaka Dental UniversityOsaka, Japan
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Akiyama, Hironori
, 
Botond Bukovszky

Botond Bukovszky

  • Centre of Radiotherapy, National Institute of OncologyBudapest, Hungary
  • Department of Oncology, Semmelweis UniversityBudapest, Hungary
  • Department of Oral Diagnostics, Semmelweis UniversityBudapest, Hungary
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Bukovszky, Botond
 et 
Zoltán Takácsi-Nagy

Zoltán Takácsi-Nagy

  • Centre of Radiotherapy, National Institute of OncologyBudapest, Hungary
  • Department of Oncology, Semmelweis UniversityBudapest, Hungary
  • National Tumour Biology Laboratory, National Institute of OncologyBudapest, Hungary
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Takácsi-Nagy, Zoltán
  
30 nov. 2023
Dosimetric comparison of postoperative interstitial high-dose-rate brachytherapy and modern external beam radiotherapy modalities in tongue and floor of the mouth tumours in terms of doses to critical organs's Cover Image
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Catégorie d'article: Research Article
Publié en ligne: 30 nov. 2023
Pages: 516 - 523
Reçu: 19 mai 2023
Accepté: 23 août 2023
DOI: https://doi.org/10.2478/raon-2023-0050
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© 2023 Örs Ferenczi et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

FIGURE 1.

Representative dose distributions in a brachytherapy (BT), a volumetric modulated arc therapy (VMAT) and a Cyberknife (CK) plan.
Representative dose distributions in a brachytherapy (BT), a volumetric modulated arc therapy (VMAT) and a Cyberknife (CK) plan.

FIGURE 2.

Mean dose in % to the most exposed 2 cm3 volume of the mandible.BT = brachytherapy; CK = Cyberknife; VMAT = volumetric modulated arc therapy
Mean dose in % to the most exposed 2 cm3 volume of the mandible.BT = brachytherapy; CK = Cyberknife; VMAT = volumetric modulated arc therapy

FIGURE 3.

Mean dose to the most exposed 2 cm3 volume of the ipsilateral parotid.BT = brachytherapy; CK = Cyberknife; VMAT = volumetric modulated arc therapy
Mean dose to the most exposed 2 cm3 volume of the ipsilateral parotid.BT = brachytherapy; CK = Cyberknife; VMAT = volumetric modulated arc therapy

Mean dosimetric parameters of organs at risk (OARs) with ranges

BT VMAT CK p-value* BT vs. VMAT** BT vs. CK** VMAT vs. CK**
Mandible D2 (%) 47.4 (29.2–73.4) 92.2 (73.1–100.4) 68.4 (39.3–87.3) < 0.001 < 0.001 < 0.001 < 0.001
D0.1 (%) 73.9 (1.7–93.9) 101.8 (97.1–103.9) 92.3 (72.7–100.7) < 0.001 < 0.001 < 0.001 NS
Ipsilateral parotid gland D2 (%) 4.8 (2.5–11.9) 7.3 (0.9–13.9) 2.3 (0.3–6.7) < 0.001 0.0011 NS < 0.001
D0.1 (%) 6.7 (3.5–19.0) 13.8 (3.7–25.0) 5.1 (0.3–12.3) < 0.001 < 0.001 NS < 0.001
Contralateral parotid gland D2 (%) 3. (0.0–7.6) 6.8 (0.6–15.8) 1.5 (0.0–4.7) < 0.001 0.0018 NS < 0.001
D0.1 (%) 4.9 (0.0–11.9) 10.9 (0.9–20.2) 3.3 (0.3–14.0) < 0.001 0.0105 NS 0.0020
Contralateral submandibular gland D2 (%) 7.3 (3.9–16.3) 9.0 (0.8–17.7) 3.6 (2.0–6.0) 0.0098 NS 0.0198 0.0016
D0.1 (%) 9.4 (6.2–21.4) 14.3 (2.1–23.1) 5.6 (3.0–11.3) 0.0098 NS 0.0146 < 0.001

Mean dosimetric parameters of planning target volume (PTV) with ranges

BT VMAT CK p-value* BT vs. VMAT** BT vs. CK** VMAT vs. CK**
VPTV (cm3) 12.5 (2.6–21.5) 26.5 (7.7–42.6) 17.5 (5.6–33.6) < 0.001 < 0.001 0.5553 0.0043
Conformal index 0.62 (0.48–0.80) 0.84 (0.78–0.87) 0.86 (0.79–0.93) < 0.001 < 0.001 < 0.001 0.5480
Homogenity index DNR = 0.38 (0.30–0.50) 0.09 (0.05 – 0.10) 0.20 (0.17–0.20) NA NA NA < 0.001
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Médecine, Médecine clinique, Médecine interne, Hématologie, oncologie, Radiologie
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