This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Mohler JL, Antonarakis ES, Armstrong AJ, D’Amico AV, Davis BJ, Dorf, T, et al. Prostate Cancer, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 2019; 17: 479-505. doi: 10.6004/ jnccn.2019.0023MohlerJLAntonarakisESArmstrongAJD’AmicoAVDavisBJTDorfetalProstate Cancer, Version 2.2019, NCCN Clinical Practice Guidelines in OncologyJ Natl Compr Canc Netw20191747950510.6004/jnccn.2019.002331085757Open DOISearch in Google Scholar
Leitlinienprogramm Onkologie, S3-Leitlinie Prostatakarzinom, Version 5.1, 05/2019. [Internet]. [cited 2022 Jan 14]. Available at: https://www.leitlinienprogramm-onkologie.de/fileadmin/user_upload/Downloads/Leitlinien/Prostata_5_0/LL_Prostatakarzinom_Langversion_5.1.pdfLeitlinienprogramm Onkologie, S3-Leitlinie Prostatakarzinom, Version 5.1, 05/2019. [Internet][cited 2022 Jan 14]. Available athttps://www.leitlinienprogramm-onkologie.de/fileadmin/user_upload/Downloads/Leitlinien/Prostata_5_0/LL_Prostatakarzinom_Langversion_5.1.pdfSearch in Google Scholar
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin 2019; 69: 7-34. doi: 10.3322/caac.21551.SiegelRLMillerKDJemalACancer statistics, 2019CA Cancer J Clin20196973410.3322/caac.2155130620402Open DOISearch in Google Scholar
Seattle cancer alliance - treating high-risk or recurrent prostate cancer. [Internet]. [cited 2020 Apr 18]. Available at: https://www.seattlecca.org/diseases/prostate-cancer/treatment-options/treating-high-risk-or- recurrent-prostate-cancer.Seattle cancer alliance - treating high-risk or recurrent prostate cancer. [Internet]. [cited 2020 Apr 18]Available athttps://www.seattlecca.org/diseases/prostate-cancer/treatment-options/treating-high-risk-or-recurrent-prostate-cancer.Search in Google Scholar
Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JWW, Comber H, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer 2013; 49: 1374-403. doi: 10.1016/j.ejca.2012.12.027FerlayJSteliarova-FoucherELortet-TieulentJRossoSCoeberghJWWComberHet alCancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012Eur J Cancer201349137440310.1016/j.ejca.2012.12.02723485231Open DOISearch in Google Scholar
Statistisches Bundesamt - Sterbefälle durch Krebs insgesamt 2019. [Internet]. [cited 2021 Apr 25]. Available at: https://www.destatis.de/DE/Themen/Gesellschaft-Umwelt/Gesundheit/Todesursachen/Tabellen/sterbefaelle-krebs-insgesamt.htmlStatistisches Bundesamt - Sterbefälle durch Krebs insgesamt2019[Internet]. [cited 2021 Apr 25]. Available athttps://www.destatis.de/DE/Themen/Gesellschaft-Umwelt/Gesundheit/Todesursachen/Tabellen/sterbefaelle-krebs-insgesamt.htmlSearch in Google Scholar
Hamdy FC, Donovan JL, Lane JA, Mason M, Metcalfe C, Holding P, et al. 10-year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer. N Engl J Med 2016; 375: 1415-24. doi: 10.1056/ NEJMoa1606220HamdyFCDonovanJLLaneJAMasonMMetcalfeCHoldingPet al10-year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancerN Engl J Med201637514152410.1056/NEJMoa160622027626136Open DOISearch in Google Scholar
Renfer LG, Schow D, Thompson IM, Optenberg S. Is ultrasound guidance necessary for transrectal prostate biopsy? J Urol 1995; 154: 1390-1. PMID: 7658544RenferLGSchowDThompsonIMOptenbergSIs ultrasound guidance necessary for transrectal prostate biopsy?J Urol199515413901PMID: 765854410.1016/S0022-5347(01)66873-3Search in Google Scholar
Abuzallouf S, Dayes I, Lukka H. Baseline staging of newly diagnosed prostate cancer: a summary of the literature. J Urol 2004; 171: 2122-7. doi: 10.1097/01.ju.0000123981.03084.06AbuzalloufSDayesILukkaHBaseline staging of newly diagnosed prostate cancer: a summary of the literatureJ Urol20041712122710.1097/01.ju.0000123981.03084.0615126770Open DOISearch in Google Scholar
Fütterer JJ, Briganti A, De Visschere P, Emberton M, Giannarini G, Kirkham A, et al. Can clinically significant prostate cancer be detected with multiparametric magnetic resonance imaging? A systematic review of the literature. Eur Urol 2015; 68: 1045-53. doi: 10.1016/j.eururo.2015.01.013FüttererJJBrigantiADe VisscherePEmbertonMGiannariniGKirkhamAet alCan clinically significant prostate cancer be detected with multiparametric magnetic resonance imaging? A systematic review of the literatureEur Urol20156810455310.1016/j.eururo.2015.01.01325656808Open DOISearch in Google Scholar
Perera M, Papa N, Christidis D, Wetherell D, Hofman MS, Murphy DG, et al. Sensitivity, specificity, and predictors of positive 68Ga–prostate-specific membrane antigen positron emission tomography in advanced prostate cancer: a systematic review and meta-analysis. Eur Urol 2016; 70: 926-37. doi: 10.1016/j.eururo.2016.06.021PereraMPapaNChristidisDWetherellDHofmanMSMurphyDGet alSensitivity, specificity, and predictors of positive 68Ga–prostate-specific membrane antigen positron emission tomography in advanced prostate cancer: a systematic review and meta-analysisEur Urol2016709263710.1016/j.eururo.2016.06.02127363387Open DOISearch in Google Scholar
Wachter S, Gerstner N, Goldner G, Dieckmann K, Colotto A, Pötter R. Three dimensional conformal photon radiotherapy at a moderate dose level of 66 Gy for prostate carcinoma: early results. Strahlenther Onkol 1997; 175(Suppl. 2): 84-6. doi: 10.1007/BF03038898.WachterSGerstnerNGoldnerGDieckmannKColottoAPötterRThree dimensional conformal photon radiotherapy at a moderate dose level of 66 Gy for prostate carcinoma: early resultsStrahlenther Onkol1997175Suppl. 284610.1007/BF0303889810394407Open DOISearch in Google Scholar
Sharfo AWM, Dirkx MLP, Bijman RG, Schillemans W, Breedveld S, Aluwini S, et al. Late toxicity in the randomized multicenter HYPRO trial for prostate cancer analyzed with automated treatment planning. Radiother Oncol 2018; 128: 349-56. doi: 10.1016/j.radonc.2018.05.028SharfoAWMDirkxMLPBijmanRGSchillemansWBreedveldSAluwiniSet alLate toxicity in the randomized multicenter HYPRO trial for prostate cancer analyzed with automated treatment planningRadiother Oncol20181283495610.1016/j.radonc.2018.05.02829885745Open DOISearch in Google Scholar
Kupelian PA, Potters L, Khuntia D, Ciezki JP, Reddy CA, Reuther AM, et al. Radical prostatectomy, external beam radiotherapy <72 Gy, external beam radiotherapy ≥72 Gy, permanent seed implantation, or combined seeds/ external beam radiotherapy for stage T1-T2 prostate cancer. Int J Radiat Oncol Biol Phys 2004; 58: 25-33. doi: 10.1016/s0360-3016(03)00784-3.KupelianPAPottersLKhuntiaDCiezkiJPReddyCAReutherAMet alRadical prostatectomy, external beam radiotherapy <72 Gy, external beam radiotherapy ≥72 Gy, permanent seed implantation, or combined seeds/ external beam radiotherapy for stage T1-T2 prostate cancerInt J Radiat Oncol Biol Phys200458253310.1016/s0360-3016(03)00784-314697417Open DOISearch in Google Scholar
Pasalic D, Kuban DA, Allen PK, Tang C, Mesko SM, Grant SR, et al. Dose escalation for prostate adenocarcinoma: a long-term update on the outcomes of a Phase 3, single institution randomized clinical trial. Int J Radiat Oncol Biol Phys 2019; 104: 790-7. doi: 10.1016/j.ijrobp.2019.02.045PasalicDKubanDAAllenPKTangCMeskoSMGrantSRet alDose escalation for prostate adenocarcinoma: a long-term update on the outcomes of a Phase 3, single institution randomized clinical trialInt J Radiat Oncol Biol Phys2019104790710.1016/j.ijrobp.2019.02.045657968430836166Open DOISearch in Google Scholar
Dearnaley DP, Sydes MR, Graham JD, Aird EG, Bottomley D, Cowan RA, et al. Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial. Lancet Oncol 2007; 8: 475-87. doi: 10.1016/S1470-2045(07)70143-2DearnaleyDPSydesMRGrahamJDAirdEGBottomleyDCowanRAet alEscalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trialLancet Oncol200784758710.1016/S1470-2045(07)70143-217482880Open DOISearch in Google Scholar
Peeters STH, Heemsbergen WD, Koper PCM, Van Putten WLJ, Slot A, Dielwart MFH, et al. Dose-response in radiotherapy for localized prostate cancer: results of the Dutch multicenter randomized phase III trial comparing 68 Gy of radiotherapy with 78 Gy. J Clin Oncol 2006; 24: 1990-6. doi: 10.1200/JCO.2005.05.2530PeetersSTHHeemsbergenWDKoperPCMVanPutten WLJSlotADielwartMFHet alDose-response in radiotherapy for localized prostate cancer: results of the Dutch multicenter randomized phase III trial comparing 68 Gy of radiotherapy with 78 GyJ Clin Oncol2006241990610.1200/JCO.2005.05.253016648499Open DOISearch in Google Scholar
Nabid A, Carrier N, Martin AG, Bahary JP, Lemaire C, Vass S, et al. Duration of androgen deprivation therapy in high-risk prostate cancer: a randomized Phase III trial. Eur Urol 2018; 74: 432-41. doi: 10.1016/j.eururo.2018.06.018NabidACarrierNMartinAGBaharyJPLemaireCVassSet alDuration of androgen deprivation therapy in high-risk prostate cancer: a randomized Phase III trialEur Urol2018744324110.1016/j.eururo.2018.06.01829980331Open DOISearch in Google Scholar
Denham JW, Joseph D, Lamb DS, Spry NA, Duchesne G, Matthews J, et al. Short-term androgen suppression and radiotherapy versus intermediateterm androgen suppression and radiotherapy, with or without zoledronic acid, in men with locally advanced prostate cancer (TROG 03.04 RADAR): 10-year results from a randomised, phase 3. Lancet Oncol 2019; 20: 267-81. doi: 10.1016/S1470-2045(18)30757-5DenhamJWJosephDLambDSSpryNADuchesneGMatthewsJet alShort-term androgen suppression and radiotherapy versus intermediateterm androgen suppression and radiotherapy, with or without zoledronic acid, in men with locally advanced prostate cancer (TROG 03.04 RADAR): 10-year results from a randomised, phase 3Lancet Oncol2019202678110.1016/S1470-2045(18)30757-530579763Open DOISearch in Google Scholar
Bolla M, De Reijke TM, Van Tienhoven G, Van Den Bergh ACM, Oddens J, Poortmans PMP, et al. Duration of androgen suppression in the treatment of prostate cancer. N Engl J Med 2009; 360: 2516-27. doi: 10.1056/ NEJMoa0810095BollaMDe ReijkeTMVanTienhoven GVanDen Bergh ACMOddensJPoortmansPMPet alDuration of androgen suppression in the treatment of prostate cancerN Engl J Med200936025162710.1056/NEJMoa081009519516032Open DOISearch in Google Scholar
Warde P, Mason M, Ding K, Kirkbride P, Brundage M, Cowan R, et al. Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial. Lancet 2011; 378: 2104-11. doi: 10.1016/S0140-6736(11)61095-7WardePMasonMDingKKirkbridePBrundageMCowanRet alCombined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trialLancet201137821041110.1016/S0140-6736(11)61095-7324393222056152Open DOISearch in Google Scholar
Bria E, Cuppone F, Giannarelli D, Milella M, Ruggeri EM, Sperduti I, et al. Does hormone treatment added to radiotherapy improve outcome in locally advanced prostate cancer? Meta-analysis of randomized trials. Cancer 2009; 115: 3446-56. doi: 10.1002/cncr.24392BriaECupponeFGiannarelliDMilellaMRuggeriEMSperdutiIet alDoes hormone treatment added to radiotherapy improve outcome in locally advanced prostate cancer? Meta-analysis of randomized trialsCancer200911534465610.1002/cncr.2439219484790Open DOISearch in Google Scholar
Bolla M, Van Tienhoven G, Warde P, Dubois JB, Mirimanoff RO, Storme G, et al. External irradiation with or without long-term androgen suppression for prostate cancer with high metastatic risk: 10-year results of an EORTC randomised study. Lancet Oncol 2010; 11: 1066-73. doi: 10.1016/S1470-2045(10)70223-0BollaMVanTienhoven GWardePDuboisJBMirimanoffROStormeGet alExternal irradiation with or without long-term androgen suppression for prostate cancer with high metastatic risk: 10-year results of an EORTC randomised studyLancet Oncol20101110667310.1016/S1470-2045(10)70223-020933466Open DOISearch in Google Scholar
ICRU Report 62. Prescribing, recording, and reporting photon beam therapy (Supplement to ICRU Report 50). [Internet]. Bethesda: International Commission on Radiation Units and Measurements; 1999. [cited 2020 Apr 18]. Available at: http://www.mendeley.com/catalog/prescribing-recording-reporting-photon-beam-therapy-report-62/ICRU Report 62. Prescribing, recording, and reporting photon beam therapy (Supplement to ICRU Report 50). [Internet]. Bethesda: International Commission on Radiation Units and Measurements; 1999. [cited 2020 Apr 18]Available athttp://www.mendeley.com/catalog/prescribing-recording-reporting-photon-beam-therapy-report-62/Search in Google Scholar
Wachter S, Gerstner N, Dorner D, Goldner G, Colotto A, Wambersie A, et al. The influence of a rectal balloon tube as internal immobilization device on variations of volumes and dose-volume histograms during treatment course of conformal radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 2002; 52: 91-100. doi: 10.1016/s0360-3016(01)01821-1WachterSGerstnerNDornerDGoldnerGColottoAWambersieAet alThe influence of a rectal balloon tube as internal immobilization device on variations of volumes and dose-volume histograms during treatment course of conformal radiotherapy for prostate cancerInt J Radiat Oncol Biol Phys2002529110010.1016/s0360-3016(01)01821-111777626Open DOISearch in Google Scholar
Roach M, Hanks G, Thames H, Schellhammer P, Shipley WU, Sokol GH, et al. Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: Recommendations of the RTOG-ASTRO Phoenix Consensus Conference. Int J Radiat Oncol Biol Phys 2006; 65: 965-74. doi: 10.1016/j.ijrobp.2006.04.029RoachMHanksGThamesHSchellhammerPShipleyWUSokolGHet alDefining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: Recommendations of the RTOG-ASTRO Phoenix Consensus ConferenceInt J Radiat Oncol Biol Phys2006659657410.1016/j.ijrobp.2006.04.02916798415Open DOISearch in Google Scholar
Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol 1995; 31: 1341-6. doi: 10.1016/0360-3016(95)00060-CCoxJDStetzJPajakTFToxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)Int J Radiat Oncol1995311341610.1016/0360-3016(95)00060-C7713792Open DOISearch in Google Scholar
Ozyigit G, Onal C, Igdem S, Alicikus ZA, Iribas A, Akin M, et al. Treatment outcomes of prostate cancer patients with Gleason score 8–10 treated with definitive radiotherapy: TROD 09-001 multi-institutional study. Strahlentherapie und Onkol 2019; 195: 882-93. doi: 10.1007/s00066-019-01476-zOzyigitGOnalCIgdemSAlicikusZAIribasAAkinMet alTreatment outcomes of prostate cancer patients with Gleason score 8–10 treated with definitive radiotherapy: TROD 09-001 multi-institutional studyStrahlentherapie und Onkol20191958829310.1007/s00066-019-01476-z31143994Open DOISearch in Google Scholar
Yu T, Zhang Q, Zheng T, Shi H, Liu Y, Feng S, et al. The effectiveness of intensity modulated radiation therapy versus three-dimensional radiation therapy in prostate cancer: a meta-analysis of the literatures. PLoS One 2016; 11: 1-17. doi: 10.1371/journal.pone.0154499.YuTZhangQZhengTShiHLiuYFengSet alThe effectiveness of intensity modulated radiation therapy versus three-dimensional radiation therapy in prostate cancer: a meta-analysis of the literaturesPLoS One20161111710.1371/journal.pone.0154499486513827171271Open DOISearch in Google Scholar
Dearnaley D, Griffin CL, Lewis R, Mayles P, Mayles H, Naismith OF, et al. Toxicity and patient-reported outcomes of a Phase 2 randomized trial of prostate and pelvic lymph node versus prostate only radiotherapy in advanced localised prostate cancer (PIVOTAL). Int J Radiat Oncol Biol Phys 2019; 103: 605-17. doi: 10.1016/j.ijrobp.2018.10.003DearnaleyDGriffinCLLewisRMaylesPMaylesHNaismithOFet alToxicity and patient-reported outcomes of a Phase 2 randomized trial of prostate and pelvic lymph node versus prostate only radiotherapy in advanced localised prostate cancer (PIVOTAL)Int J Radiat Oncol Biol Phys20191036051710.1016/j.ijrobp.2018.10.003636176830528653Open DOISearch in Google Scholar
Rammant E, Ost P, Swimberghe M, Vanderstraeten B, Lumen N, Decaestecker K, et al. Patient- versus physician-reported outcomes in prostate cancer patients receiving hypofractionated radiotherapy within a randomized controlled trial. Strahlenther Onkol 2019; 195: 393-401. doi: 10.1007/s00066-018-1395-yRammantEOstPSwimbergheMVanderstraetenBLumenNDecaesteckerKet alPatient- versus physician-reported outcomes in prostate cancer patients receiving hypofractionated radiotherapy within a randomized controlled trialStrahlenther Onkol201919539340110.1007/s00066-018-1395-y30406289Open DOISearch in Google Scholar
Kerkmeijer LGW, Groen VH, Pos FJ, Haustermans K, Monninkhof EM, Smeenk RJ, et al. Focal boost to the intraprostatic tumor in external beam radiotherapy for patients with localized prostate cancer: results from the FLAME randomized Phase III trial. J Clin Oncol 2021; 39: 787-96. doi: 10.1200/JCO.20.02873KerkmeijerLGWGroenVHPosFJHaustermansKMonninkhofEMSmeenkRJet alFocal boost to the intraprostatic tumor in external beam radiotherapy for patients with localized prostate cancer: results from the FLAME randomized Phase III trialJ Clin Oncol2021397879610.1200/JCO.20.0287333471548Open DOISearch in Google Scholar