<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_raon-2019-0035_s_006">
<h3>Background</h3>
<p>The study was conducted to evaluate the effect of sex hormones on F-18 fluorodeoxyglucose (<sup>18</sup>F-FDG) uptake by normal ovaries.</p>
</sec>
<sec id="j_raon-2019-0035_s_007">
<h3>Patients and methods</h3>
<p>A total of 197 premenopausal women were included in this study. Based on <sup>18</sup>F-FDG positron emission tomography/computed tomography (PET/CT) images obtained from these subjects, the association of ovarian <sup>18</sup>F-FDG uptake with levels of sex hormones, including estradiol, progesterone, testosterone, follicle-stimulating hormone, and luteinizing hormone was investigated. We also analysed the relationship between the menstrual cycle and ovarian <sup>18</sup>F-FDG uptake.</p>
</sec>
<sec id="j_raon-2019-0035_s_008">
<h3>Results</h3>
<p>The highest ovarian <sup>18</sup>F-FDG uptake occurred at 2 weeks after the onset of menstruation (median maximum standardized uptake value [SUVmax] = 3.40, median mean SUV [SUVmean] = 2.20), and the lowest ovarian <sup>18</sup>F-FDG uptake was observed during the first week of the menstrual cycle (median SUVmax = 1.60, median SUVmean = 1.20). Ovarian <sup>18</sup>F-FDG uptake was weakly positively correlated with progesterone levels (<italic>rho</italic> = 0.28, <italic>p</italic> &lt; 0.001 for SUVmax, <italic>rho</italic> = 0.30, <italic>p</italic> &lt; 0.001 for SUVmean), and this pattern was consistently observed in subjects in the follicular-phase group (<italic>rho</italic> = 0.29, <italic>p</italic> = 0.003 for both SUVmax and SUVmean) but not in subjects in the luteal-phase group.</p>
</sec>
<sec id="j_raon-2019-0035_s_009">
<h3>Conclusions</h3>
<p>Based on PET images, ovarian glucose metabolism in premenopausal women tended to increase slightly with increasing progesterone concentration.</p>
</sec>
</abstract>

Background
The study was conducted to evaluate the effect of sex hormones on F-18 fluorodeoxyglucose (18F-FDG) uptake by normal ovaries.


Patients and methods
A total of 197 premenopausal women were included in this study. Based on 18F-FDG positron emission tomography/computed tomography (PET/CT) images obtained from these subjects, the association of ovarian 18F-FDG uptake with levels of sex hormones, including estradiol, progesterone, testosterone, follicle-stimulating hormone, and luteinizing hormone was investigated. We also analysed the relationship between the menstrual cycle and ovarian 18F-FDG uptake.


Results
The highest ovarian 18F-FDG uptake occurred at 2 weeks after the onset of menstruation (median maximum standardized uptake value [SUVmax] = 3.40, median mean SUV [SUVmean] = 2.20), and the lowest ovarian 18F-FDG uptake was observed during the first week of the menstrual cycle (median SUVmax = 1.60, median SUVmean = 1.20). Ovarian 18F-FDG uptake was weakly positively correlated with progesterone levels (rho = 0.28, p < 0.001 for SUVmax, rho = 0.30, p < 0.001 for SUVmean), and this pattern was consistently observed in subjects in the follicular-phase group (rho = 0.29, p = 0.003 for both SUVmax and SUVmean) but not in subjects in the luteal-phase group.


Conclusions
Based on PET images, ovarian glucose metabolism in premenopausal women tended to increase slightly with increasing progesterone concentration.

Relationship between sex hormones levels and <sup>18</sup>F-FDG uptake by the ovaries in premenopausal woman

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Relationship between sex hormones levels and F-FDG uptake by the ovaries in premenopausal woman

Background
The study was conducted to evaluate the effect of sex hormones on F-18 fluorodeoxyglucose (18F-FDG) uptake by normal ovaries.


Patients and...

Relationship between sex hormones levels and ¹⁸F-FDG uptake by the ovaries in premenopausal woman

Article Category: Research Article

Publié en ligne: 24 sept. 2019

Pages: 293 - 299

Reçu: 30 avr. 2019

Accepté: 17 juil. 2019

DOI: https://doi.org/10.2478/raon-2019-0035

© 2019 Tae Hee Kim, Mi Ran Kim, Yongsik Jung, Young-Sil An, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Relationship between sex hormones levels and 18F-FDG uptake by the ovaries in premenopausal woman

Article Category: Research Article

Publié en ligne: 24 sept. 2019

Pages: 293 - 299

Reçu: 30 avr. 2019

Accepté: 17 juil. 2019

DOI: https://doi.org/10.2478/raon-2019-0035

© 2019 Tae Hee Kim, Mi Ran Kim, Yongsik Jung, Young-Sil An, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Relationship between sex hormones levels and ¹⁸F-FDG uptake by the ovaries in premenopausal woman