<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2018-0042_s_006_w2aab3b7b9b1b6b1aab1c18b1Aa"><h3>Background</h3><p>The aim of the study was to present dosimetric comparison of image guided high-dose-rate brachytherapy (IGBT) with volumetric modulated arc therapy (VMAT) for head and neck cancer regarding conformity of dose distribution to planning target volume (PTV) and doses to organs at risk (OARs).</p></sec><sec id="j_raon-2018-0042_s_007_w2aab3b7b9b1b6b1aab1c18b2Aa"><h3>Patients and methods</h3><p>Thirty-eight consecutive patients with T1-4 mobile tongue, floor of mouth and base of tongue cancer treated with IGBT were selected. For these patients additional VMAT treatment plans were also prepared using identical computed tomography data. OARs and PTV related parameters (<italic>e.g</italic>. V98, D0.1cm<sup>3</sup>, Dmean, <italic>etc</italic>.) were compared.</p></sec><sec id="j_raon-2018-0042_s_008_w2aab3b7b9b1b6b1aab1c18b3Aa"><h3>Results</h3><p>Mean V98 of the PTV was 90.2% <italic>vs</italic>. 90.4% (<italic>p ></italic> 0.05) for IGBT and VMAT, respectively. Mean D0.1cm<sup>3</sup> to the mandible was 77.0% <italic>vs</italic>. 85.4% (<italic>p &lt;</italic> 0.05). Dmean to ipsilateral and contralateral parotid glands was 4.6% <italic>vs</italic>. 4.6% and 3.0% <italic>vs</italic>. 3.9% (<italic>p ></italic> 0.05). Dmean to ipsilateral and contralateral submandibular glands was 16.4% <italic>vs</italic>. 21.9% (<italic>p ></italic> 0.05) and 8.2% <italic>vs</italic>. 16.9% (<italic>p &lt;</italic> 0.05), respectively.</p></sec><sec id="j_raon-2018-0042_s_009_w2aab3b7b9b1b6b1aab1c18b4Aa"><h3>Conclusions</h3><p>Both techniques showed excellent target coverage. With IGBT dose to normal tissues was lower than with VMAT. The results prove the superiority of IGBT in the protection of OARs and the important role of this invasive method in the era of new external beam techniques.</p></sec></abstract>

BackgroundThe aim of the study was to present dosimetric comparison of image guided high-dose-rate brachytherapy (IGBT) with volumetric modulated arc therapy (VMAT) for head and neck cancer regarding conformity of dose distribution to planning target volume (PTV) and doses to organs at risk (OARs).Patients and methodsThirty-eight consecutive patients with T1-4 mobile tongue, floor of mouth and base of tongue cancer treated with IGBT were selected. For these patients additional VMAT treatment plans were also prepared using identical computed tomography data. OARs and PTV related parameters (e.g. V98, D0.1cm3, Dmean, etc.) were compared.ResultsMean V98 of the PTV was 90.2% vs. 90.4% (p > 0.05) for IGBT and VMAT, respectively. Mean D0.1cm3 to the mandible was 77.0% vs. 85.4% (p < 0.05). Dmean to ipsilateral and contralateral parotid glands was 4.6% vs. 4.6% and 3.0% vs. 3.9% (p > 0.05). Dmean to ipsilateral and contralateral submandibular glands was 16.4% vs. 21.9% (p > 0.05) and 8.2% vs. 16.9% (p < 0.05), respectively.ConclusionsBoth techniques showed excellent target coverage. With IGBT dose to normal tissues was lower than with VMAT. The results prove the superiority of IGBT in the protection of OARs and the important role of this invasive method in the era of new external beam techniques.

Image guided high-dose-rate brachytherapy versus volumetric modulated arc therapy for head and neck cancer: A comparative analysis of dosimetry for target volume and organs at risk

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundThe aim of the study was to present dosimetric comparison of image guided high-dose-rate brachytherapy (IGBT) with volumetric modulated arc therapy (VMAT) for head and neck cancer regarding conformity of dose distribution to planning target volume (PTV) and doses to organs at risk (OARs).Patients and methodsThirty-eight consecutive patients with T1-4 mobile tongue, floor of mouth and base of tongue cancer treated with IGBT were selected. For these patients additional VMAT treatment plans were also prepared using identical computed tomography data. OARs and PTV related parameters (e.g. V98, D0.1cm3, Dmean, etc.) were compared.ResultsMean V98 of the PTV was 90.2% vs. 90.4% (p > 0.05) for IGBT and VMAT, respectively. Mean D0.1cm3 to the mandible was 77.0% vs. 85.4% (p  0.05). Dmean to ipsilateral and contralateral submandibular glands was 16.4% vs. 21.9% (p > 0.05) and 8.2% vs. 16.9% (p < 0.05), respectively.ConclusionsBoth techniques showed excellent target coverage. With IGBT dose to normal tissues was lower than with VMAT. The results prove the superiority of IGBT in the protection of OARs and the important role of this invasive method in the era of new external beam techniques.

BackgroundThe aim of the study was to present dosimetric comparison of image guided high-dose-rate brachytherapy (IGBT) with volumetric modulated arc therapy...

Image guided high-dose-rate brachytherapy versus volumetric modulated arc therapy for head and neck cancer: A comparative analysis of dosimetry for target volume and organs at risk

Article Category: Research Article

Publié en ligne: 12 nov. 2018

Pages: 461 - 467

Reçu: 19 juin 2018

Accepté: 06 oct. 2018

DOI: https://doi.org/10.2478/raon-2018-0042

© 2018 Hironori Akiyama, Csilla Pesznyák, Dalma Béla, Örs Ferenczi, Tibor Major, Csaba Polgár, Zoltán Takácsi-Nagy, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.