- | - | - | - | - | 7 | - | - | ||
2 | - | 3 | 4 | - | 28 | 4 | 1 | ||
8 | 6 | 16 | 18 | 1 | 17 | 4 | 2 | ||
1 | - | 1 | 1 | 2 |
Toxicity grade (N) | |||||
---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | |
Anaemia | 23 | 7 | 1 | 0 | 0 |
Neutropenia | 4 | 2 | 0 | 0 | |
Thrombocytopenia | 6 | 1 | 1 | 1 | 0 |
Fatigue | 5 | 0 | 0 | / | / |
Nausea/vomiting | 2 | 2 | 0 | / | / |
Hand-foot syndrome | 11 | 5 | 1 | ||
Radiodermatitis | 7 | 18 | 5 | ||
Diarrhoea | 11 | 3 | 2 | ||
Urinary infection | 6 | 0 | 0 | 0 | 0 |
Systemic infection | 0 | 1 | 0 | 1 | 0 |
Proctitis | 6 | 2 | 0 | ||
Thromboembolism | 2 | 2 | 0 | 0 | 1 |
Chest pain | 1 |
Parameter | OS | DFS |
---|---|---|
Gender | ns | ns |
Age | ns | ns |
WHO PSa | ns | ns |
Tumour location in the rectum | ns | ns |
cTumour stage | ns | ns |
cNodal stage | ns | ns |
Type of surgery: APR | ns | ns |
pT1–2 | 0.005 | 0.002 |
pT0 | 0.009 | 0.009 |
pN0 | 0.009 | 0.005 |
TRG 3–4 | ns | ns |
pCR | ns | ns |
All treatment | 0.016 | 0.018 |
Toxicity grade (N) | ||||||
---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | ||
Anaemia | 23 | 1 | ||||
Neutropenia | 1 | |||||
Fatigue | 2 | |||||
Nausea/vomiting | 2 | 1 | ||||
Hand-foot syndrome | 3 | 3 | ||||
Diarrhoea | 1 | |||||
Urinary infection | 2 | |||||
Thromboembolic event | 1 |
Median age (years) | 60 (37-81) |
Gender | |
Male | 42 (63.6%) |
Female | 24 (36.4%) |
WHO performance status | |
0 | 54 (81.8%) |
1 | 11 (16.7%) |
2 | 1 (1.5 %) |
Stage | |
T2 | 9 (13.6%) |
T3 | 50 (75.8%) |
T4 | 7 (10.6%) |
N0 | 9 (13.6%) |
N1 | 34 (51.5%) |
N2 | 23 (34.9%) |
Tumour differentiation (grade) | |
Well (G1) | 8 (12.1%) |
Moderate (G2) | 35 (53.0%) |
Poorly (G3) | 4 (6.0%) |
Unknown or not stated (GX) | 19 (28.9%) |
MRF distance | |
MRF+ | 20 |
MRF- | 44 |
Median tumour distance from the anal verge (cm) | 6 (0-12) |