<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global pandemic with serious implications and open questions for all areas of medicine, including immunocompromised patients. In Latvia, as of the end of 2022, 229 new cases of HIV were registered, reflecting an incidence rate of 12.2 per 100,000 people. Despite the fact that immunocompromised patients are at risk of poor outcomes of COVID-19, there is currently no evidence that clinical manifestations of COVID-19 in people living with HIV (PLWH) differ from those in the general population, provided these patients have well-controlled immune status (CD4+ count > 200 and undetectable viral load). We report two cases of COVID-19, specifically the Delta variant, in male patients with well-controlled HIV infection who had received three vaccine doses against COVID 19. Both patients fully recovered within one week without complications, requiring no specific treatment. Considering the current published data and our observations, it can be assumed that the course of COVID-19 in vaccinated well-controlled HIV patients does not differ from the typical clinical manifestations of COVID-19 in the general population. It is necessary to decrease vaccine hesitancy among PLWH, as COVID-19 vaccination is a crucial measure to safeguard this segment of the population against poor outcomes of COVID-19 such as hospitalisation, the risk of long-term health problems, severe disease, and death).</p>
</abstract>

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global pandemic with serious implications and open questions for all areas of medicine, including immunocompromised patients. In Latvia, as of the end of 2022, 229 new cases of HIV were registered, reflecting an incidence rate of 12.2 per 100,000 people. Despite the fact that immunocompromised patients are at risk of poor outcomes of COVID-19, there is currently no evidence that clinical manifestations of COVID-19 in people living with HIV (PLWH) differ from those in the general population, provided these patients have well-controlled immune status (CD4+ count > 200 and undetectable viral load). We report two cases of COVID-19, specifically the Delta variant, in male patients with well-controlled HIV infection who had received three vaccine doses against COVID 19. Both patients fully recovered within one week without complications, requiring no specific treatment. Considering the current published data and our observations, it can be assumed that the course of COVID-19 in vaccinated well-controlled HIV patients does not differ from the typical clinical manifestations of COVID-19 in the general population. It is necessary to decrease vaccine hesitancy among PLWH, as COVID-19 vaccination is a crucial measure to safeguard this segment of the population against poor outcomes of COVID-19 such as hospitalisation, the risk of long-term health problems, severe disease, and death).

Case Reports on COVID-19 Outcomes During the Pandemic in Patients with Well-Managed HIV Infection in Latvia

Doctoral studies, Rīga Stradiņš University

RSU Joint Laboratory of Clinical Immunology and Immunogenetics

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution 4.0 International License.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global pandemic with serious implications and open questions for all areas of...

Case Reports on COVID-19 Outcomes During the Pandemic in Patients with Well-Managed HIV Infection in Latvia

Publié en ligne: 04 mars 2024

Pages: 106 - 110

Reçu: 04 oct. 2022

Accepté: 24 janv. 2024

DOI: https://doi.org/10.2478/prolas-2024-0015

Mots clés
immunodeficiency, clinical manifestations, outcome, vaccine

© 2024 Alena Soha et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Case Reports on COVID-19 Outcomes During the Pandemic in Patients with Well-Managed HIV Infection in Latvia

Publié en ligne: 04 mars 2024

Pages: 106 - 110

Reçu: 04 oct. 2022

Accepté: 24 janv. 2024

DOI: https://doi.org/10.2478/prolas-2024-0015

Mots clésimmunodeficiency, clinical manifestations, outcome, vaccine

© 2024 Alena Soha et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Mots clés
immunodeficiency, clinical manifestations, outcome, vaccine