<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Our study was focused on identification and correction of early hyperglycaemia, with the aim to reduce the risk of developing post-transplant diabetes mellitus (PTDM) and its associated complications. In a single centre, the prospective study included adult kidney transplant recipients without diabetes mellitus whose pre-transplant glucometabolic data did not show signs of diabetes mellitus. Starting from the first day after kidney transplantation, patients were closely monitored for hyperglycaemia; glucose level measurements were started to obtain pre-prandial levels. If the blood glucose level exceeded 11.1 mmol/l, hyperglycaemia was corrected with short-acting insulin. A total of 14 patients completed a three-month follow-up. During the first post-transplant week, the blood glucose level exceeded 11.1 mmol/l in nine patients (63.9%). From those patients five (55.5%) did not develop PTDM. None of the patients who did not need insulin treatment developed PTDM. Higher pre-lunch glucose levels increased the risk of developing PTDM (p = 0.006). Patients with diabetes required a two times higher insulin dosage than other patients during the first post-transplantation week. We found that hyperglycaemia is a common problem in the early post-transplant period. Early recognition and correction of inpatient hyperglycaemia was associated with reduction of the prevalence of PTDM in more than a half of the patients in the studied group at three months post transplant.</p></abstract>

Our study was focused on identification and correction of early hyperglycaemia, with the aim to reduce the risk of developing post-transplant diabetes mellitus (PTDM) and its associated complications. In a single centre, the prospective study included adult kidney transplant recipients without diabetes mellitus whose pre-transplant glucometabolic data did not show signs of diabetes mellitus. Starting from the first day after kidney transplantation, patients were closely monitored for hyperglycaemia; glucose level measurements were started to obtain pre-prandial levels. If the blood glucose level exceeded 11.1 mmol/l, hyperglycaemia was corrected with short-acting insulin. A total of 14 patients completed a three-month follow-up. During the first post-transplant week, the blood glucose level exceeded 11.1 mmol/l in nine patients (63.9%). From those patients five (55.5%) did not develop PTDM. None of the patients who did not need insulin treatment developed PTDM. Higher pre-lunch glucose levels increased the risk of developing PTDM (p = 0.006). Patients with diabetes required a two times higher insulin dosage than other patients during the first post-transplantation week. We found that hyperglycaemia is a common problem in the early post-transplant period. Early recognition and correction of inpatient hyperglycaemia was associated with reduction of the prevalence of PTDM in more than a half of the patients in the studied group at three months post transplant.

Early Correction of Post-Kidney Transplant Hyperglycaemia is Associated with Reduction of the Prevalence of Post-Transplant Diabetes Mellitus

Pauls Stradiņš Clinical University Hospital

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Our study was focused on identification and correction of early hyperglycaemia, with the aim to reduce the risk of developing post-transplant diabetes mellitus...

Early Correction of Post-Kidney Transplant Hyperglycaemia is Associated with Reduction of the Prevalence of Post-Transplant Diabetes Mellitus

Publié en ligne: 08 mai 2021

Pages: 99 - 105

Reçu: 09 juil. 2020

Accepté: 13 janv. 2021

DOI: https://doi.org/10.2478/prolas-2021-0016

Mots clés
kidney transplantation, hyperglycaemia – glucose level measurements post-transplant diabetes, early post-transplant hyperglycaemia

© 2021 Klinta Suhecka et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Early Correction of Post-Kidney Transplant Hyperglycaemia is Associated with Reduction of the Prevalence of Post-Transplant Diabetes Mellitus

Publié en ligne: 08 mai 2021

Pages: 99 - 105

Reçu: 09 juil. 2020

Accepté: 13 janv. 2021

DOI: https://doi.org/10.2478/prolas-2021-0016

Mots cléskidney transplantation, hyperglycaemia – glucose level measurements post-transplant diabetes, early post-transplant hyperglycaemia

© 2021 Klinta Suhecka et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
kidney transplantation, hyperglycaemia – glucose level measurements post-transplant diabetes, early post-transplant hyperglycaemia