<abstract xmlns="http://www.w3.org/1999/xhtml">

Inflammatory bowel diseases are autoimmune disorders affecting the gastrointestinal tract and producing a wide variety of extraintestinal manifestations. Kidneys are a rare target organ of their extraintestinal activity, but if affected, renal function could deteriorate to end-stage kidney disease, which is curable only by organ transplantation. Renal calculi are the most common pathological kidney manifestation in IBD patients, followed by tubulointerstitial nephritis, glomerulonephritis, and other kidney pathologies.
The liver is the most commonly transplanted organ in IBD patients (primary sclerosing cholangitis and autoimmune hepatitis), and a scarcity of literature on kidney recipients is present to date regarding the incidence of renal insufficiency, kidney transplantations, post-transplant IBD course and further complications such as graft rejection or infections in this specific group of patients. De novo IBD is a paradoxical entity in the setting of rigorous post-transplant immunosuppression.
In this case series, we present three patients who underwent kidney transplantation with a history of an IBD and one patient who developed de novo Crohn’s disease after the deceased donor organ transplant was performed.
</abstract>

Inflammatory bowel diseases are autoimmune disorders affecting the gastrointestinal tract and producing a wide variety of extraintestinal manifestations. Kidneys are a rare target organ of their extraintestinal activity, but if affected, renal function could deteriorate to end-stage kidney disease, which is curable only by organ transplantation. Renal calculi are the most common pathological kidney manifestation in IBD patients, followed by tubulointerstitial nephritis, glomerulonephritis, and other kidney pathologies.
The liver is the most commonly transplanted organ in IBD patients (primary sclerosing cholangitis and autoimmune hepatitis), and a scarcity of literature on kidney recipients is present to date regarding the incidence of renal insufficiency, kidney transplantations, post-transplant IBD course and further complications such as graft rejection or infections in this specific group of patients. De novo IBD is a paradoxical entity in the setting of rigorous post-transplant immunosuppression.
In this case series, we present three patients who underwent kidney transplantation with a history of an IBD and one patient who developed de novo Crohn’s disease after the deceased donor organ transplant was performed.

Inflammatory Bowel Diseases in Renal Transplantat Recipients: A Case Series and Review of the Literature

University of Zagreb, School of medicine, University J.J. Strossmayer, Osijek

Department of nephrology, arterial hypertension, dialysis and transplantation

PRILOZI

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Inflammatory bowel diseases are autoimmune disorders affecting the gastrointestinal tract and producing a wide variety of extraintestinal manifestations....

Inflammatory Bowel Diseases in Renal Transplantat Recipients: A Case Series and Review of the Literature

Publié en ligne: 22 avr. 2022

Pages: 57 - 63

DOI: https://doi.org/10.2478/prilozi-2022-0006

Mots clés
inflammatory bowel disease, end-stage kidney disease, 5-aminosalicylate toxicity, tubulointerstitial nephritis, kidney transplantation, de novo IBD

© 2022 Jakob Vrus et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Inflammatory Bowel Diseases in Renal Transplantat Recipients: A Case Series and Review of the Literature

Publié en ligne: 22 avr. 2022

Pages: 57 - 63

DOI: https://doi.org/10.2478/prilozi-2022-0006

Mots clésinflammatory bowel disease, end-stage kidney disease, 5-aminosalicylate toxicity, tubulointerstitial nephritis, kidney transplantation, de novo IBD

© 2022 Jakob Vrus et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
inflammatory bowel disease, end-stage kidney disease, 5-aminosalicylate toxicity, tubulointerstitial nephritis, kidney transplantation, de novo IBD