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2-Methoxyestradiol Attenuates the Development and Retards the Progression of Hypoxia-And Alpha-Naphthylthiourea-Induced Pulmonary Hypertension

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1. Benza, R.L., et al., An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry. Chest, 2012. 142(2): p. 448-456.10.1378/chest.11-146022281797Search in Google Scholar

2. Escribano-Subias, P., et al., Survival in pulmonary hypertension in Spain: insights from the Spanish registry. Eur Respir J, 2012. 40(3): p. 596-603.10.1183/09031936.0010121122362843Search in Google Scholar

3. Jing, Z.C., et al., Registry and survival study in chinese patients with idiopathic and familial pulmonary arterial hypertension. Chest, 2007. 132(2): p. 373-9.10.1378/chest.06-291317400671Search in Google Scholar

4. Tamura, Y., et al., Effectiveness and Outcome of Pulmonary Arterial Hypertension-Specific Therapy in Japanese Patients With Pulmonary Arterial Hypertension. Circ J, 2017. 82(1): p. 275-282.10.1253/circj.CJ-17-013928747612Search in Google Scholar

5. Batton, K.A., et al., Sex differences in pulmonary arterial hypertension: role of infection and autoimmunity in the pathogenesis of disease. Biol Sex Differ, 2018. 9(1): p. 15.10.1186/s13293-018-0176-8590745029669571Search in Google Scholar

6. Chung, L., et al., Unique predictors of mortality in patients with pulmonary arterial hypertension associated with systemic sclerosis in the REVEAL registry. Chest, 2014. 146(6): p. 1494-1504.10.1378/chest.13-3014425161324992469Search in Google Scholar

7. Tofovic, S.P., et al., Estradiol metabolites attenuate monocrotaline-induced pulmonary hyper-tension in rats. J Cardiovasc Pharmacol, 2005. 46(4): p. 430-7.10.1097/01.fjc.0000175878.32920.1716160593Search in Google Scholar

8. Tofovic, S.P., et al., 2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension. Vascul Pharmacol, 2006. 45(6): p. 358-67.10.1016/j.vph.2006.05.00716872912Search in Google Scholar

9. Tofovic, S.P., et al., 2-methoxyestradiol attenuates bleomycin-induced pulmonary hypertension and fibrosis in estrogen-deficient rats. Vascul Pharmacol, 2009. 51(2-3): p. 190-7.10.1016/j.vph.2009.06.002276030019540933Search in Google Scholar

10. Tofovic, S.P., Estrogens and development of pulmonary hypertension: interaction of estradiol metabolism and pulmonary vascular disease. J Cardiovasc Pharmacol, 2010. 56(6): p. 696-708.10.1097/FJC.0b013e3181f9ea8d302783920881610Search in Google Scholar

11. Austin, E.D., et al., Gender, sex hormones and pulmonary hypertension. Pulm Circ, 2013. 3(2): p. 294-314.10.4103/2045-8932.114756375782424015330Search in Google Scholar

12. Tofovic, S.P. and E.K. Jackson, Estradiol Metabolism: Crossroads in Pulmonary Arterial Hyper-tension. Int J Mol Sci, 2019. 21(1).10.3390/ijms21010116698232731877978Search in Google Scholar

13. Austin, E.D., et al., Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females. Eur Respir J, 2009. 34(5): p. 1093-9.10.1183/09031936.00010409374212419357154Search in Google Scholar

14. Kawut, S.M., et al., Determinants of right ventricular ejection fraction in pulmonary arterial hypertension. Chest, 2009. 135(3): p. 752-759.10.1378/chest.08-1758283478518849396Search in Google Scholar

15. Kawut, S.M., et al., Anastrozole in Pulmonary Arterial Hypertension. A Randomized, Double-Blind, Placebo-controlled Trial. Am J Respir Crit Care Med, 2017. 195(3): p. 360-368.10.1164/rccm.201605-1024OCSearch in Google Scholar

16. Ventetuolo, C.E., et al., Higher Estradiol and Lower Dehydroepiandrosterone-Sulfate Levels Are Associated with Pulmonary Arterial Hypertension in Men. Am J Respir Crit Care Med, 2016. 193(10): p. 1168-75.10.1164/rccm.201509-1785OC487266526651504Search in Google Scholar

17. Ventetuolo, C.E., et al., Oestradiol metabolism and androgen receptor genotypes are associated with right ventricular function. Eur Respir J, 2016. 47(2): p. 553-63.10.1183/13993003.01083-2015483113526647441Search in Google Scholar

18. Tofovic, S.P. and E.K. Jackson, Complexities of oestradiol pharmacology in pulmonary arterial hypertension. Eur Respir J, 2013. 41(6): p. 1465-6.10.1183/09031936.0016491223728411Search in Google Scholar

19. Tofovic, S.P. and E.K. Jackson, Estrogens in Men: Another Layer of Complexity of Estradiol Metabolism in Pulmonary Hypertension. Am J Respir Crit Care Med, 2016. 193(10): p. 1087-90.10.1164/rccm.201512-2541ED487267327174480Search in Google Scholar

20. Tofovic, S.P.a.J., E.K., 2-Methoxyestradiol in Pulmonary Arterial Hypertension: A New Disease Modifier, in Pulmonary Circulation and Ventilation. 2019, IntechOpen.10.5772/intechopen.86812Search in Google Scholar

21. Kay, J.M., Effect of intermittent normoxia on chronic hypoxic pulmonary hypertension, right ventricular hypertrophy, and polycythemia in rats. Am Rev Respir Dis, 1980. 121(6): p. 993-1001.Search in Google Scholar

22. Swigart, R.H., Polycythemia and Right Ventricular Hypertrophy. Circ Res, 1965. 17: p. 30-8.10.1161/01.RES.17.1.3014302550Search in Google Scholar

23. Naeije, R. and C. Dedobbeleer, Pulmonary hypertension and the right ventricle in hypoxia. Exp Physiol, 2013. 98(8): p. 1247-56.10.1113/expphysiol.2012.06911223625956Search in Google Scholar

24. Tofovic SP, Z.X., Jones T,Jackson EK, Petrusevska G., 2-Methoxyestradiol attenuates the development and retards the progression of chronic hypoxia-induced pulmonary hypertension in rats. Circulation, 2005. 112: p. 98-99.Search in Google Scholar

25. Hao, S., et al., 2-Methoxyestradiol attenuates chronic-intermittent-hypoxia-induced pulmonary hypertension through regulating microRNA-223. J Cell Physiol, 2019. 234(5): p. 6324-6335.10.1002/jcp.2736330246291Search in Google Scholar

26. Docherty, C.K., M. Nilsen, and M.R. MacLean, Influence of 2-Methoxyestradiol and Sex on Hypoxia-Induced Pulmonary Hypertension and Hypoxia-Inducible Factor-1-alpha. J Am Heart Assoc, 2019. 8(5): p. e011628.10.1161/JAHA.118.011628647494030819028Search in Google Scholar

27. Tofovic, S.P., T. Jones, and G. Petrusevska, Dose-dependent therapeutic effects of 2-Methoxyestradiol on Monocrotaline-Induced pulmonary hypertension and vascular remodelling. Prilozi, 2010. 31(1): p. 279-95.Search in Google Scholar

28. Tofovic, S.P., et al., Synergistic therapeutic effects of 2-methoxyestradiol with either sildenafil or bosentan on amelioration of monocrotaline-induced pulmonary hypertension and vascular remodeling. J Cardiovasc Pharmacol, 2010. 56(5): p. 475-83.10.1097/FJC.0b013e3181f215e720881615Search in Google Scholar

29. Havill, A.M., et al., alpha-Naphthylthiourea produces dose-dependent lung vascular injury in sheep. Am J Physiol, 1982. 243(4): p. H505-11.10.1152/ajpheart.1982.243.4.H5056812437Search in Google Scholar

30. Hesse, F.E. and C.G. Loosli, The lining of the alveoli in mice, rats, dogs, and frogs following acute pulmonary edema produced by ANTU poisoning. Anat Rec, 1949. 105(2): p. 299-323, incl 6 pl.10.1002/ar.109105020715398723Search in Google Scholar

31. Michel, R.P., Lung microvascular permeability to dextran in alpha-naphthylthiourea-induced edema. Sites of filtration, patterns of accumulation, and effects of fixation. Am J Pathol, 1985. 119(3): p. 474-84.Search in Google Scholar

32. Verenich, S. and P.M. Gerk, Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges. Mol Pharm, 2010. 7(6): p. 2030-9.10.1021/mp100190f305989920831190Search in Google Scholar

33. Berg, D., R. Sonsalla, and E. Kuss, Concentrations of 2-methoxyoestrogens in human serum measured by a heterologous immunoassay with an 125I-labelled ligand. Acta Endocrinol (Co-penh), 1983. 103(2): p. 282-8.10.1530/acta.0.10302826858558Search in Google Scholar

34. Tofovic SP, Jackson EK, Piche C, Pharmacokinetics and safety of a subcutaneously injected long-acting formulation of 2-methoxyestradiol(2ME) in healthy volunteers. Basic & Clinical Pharmacology & Toxicology, 2009. 105: p. 107.Search in Google Scholar

35. Ba, M. and Y. Duan, Advance of 2-methoxyestradiol as a promising anticancer agent for cancer therapy. Future Med Chem, 2020. 12(4): p. 273-275.10.4155/fmc-2019-025831983223Search in Google Scholar

36. Kumar, B.S., et al., Recent Advances in chemistry and pharmacology of 2-methoxyestradiol: An anticancer investigational drug. Steroids, 2016. 110: p. 9-34.10.1016/j.steroids.2016.03.01727020471Search in Google Scholar

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