[1. Heikkinen AM, Kettunen K, Kovanen L, Haukka J, Elg J, Husu H, Tervahartiala T, Pussinen P, Meurman J, Sorsa T.Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents.Clin Exp Dent Res. 2016 Sep 30; 2(3): 208–215. doi: 10.1002/cre2.40.eCollection 2016 Dec.10.1002/cre2.40.eCollection2016Dec]Open DOISearch in Google Scholar
[2. Offenbacher S. Periodontal diseases: pathogenesis. Ann Periodontol 1996; 1: 821–878.10.1902/annals.1996.1.1.8219118282]Search in Google Scholar
[3. Korrnman KS, Crane A, Wang HY, di Giovine FS, Newman MG, Pirk FW et al. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol 1997; 24(1): 72–7.10.1111/j.1600-051X.1997.tb01187.x]Open DOISearch in Google Scholar
[4. Deppe H, Mücke T, Wagenpfeil S, Kesting M, Karl J, Noe S, Sculean A. Are selected IL-1 polymorphisms and selected subgingival microorganisms significantly associated to periodontitis in type 2 diabetes patients? a clinical study. BMC Oral Health. 2015 Nov 14; 15(1): 143. doi: 10.1186/s12903-015-0132-5.10.1186/s12903-015-0132-5465028826576766]Open DOISearch in Google Scholar
[5. Maney P, Owens JL.Interleukin polymorphisms in aggressive periodontitis: A literature review.J Indian Soc Periodontol. 2015 Mar-Apr; 19(2): 131–41. doi: 10.4103/0972-124X.145787. Review.10.4103/0972-124X.145787.]Open DOISearch in Google Scholar
[6. Lavu V, Venkatesan V, Venkata Kameswara Subrahmanya Lakkakula B, Venugopal P, Paul SF, Rao SR.Polymorphic regions in the interleukin-1 gene and susceptibility to chronic periodontitis: a genetic association study. Genet Test Mol Bio-markers. 2015 Apr; 19(4): 175–81. doi: 10.1089/gtmb.2014.0275. Epub 2015 Feb 24.10.1089/gtmb.2014.0275.Epub2015Feb24]Open DOISearch in Google Scholar
[7. Puri K, Chhokra M, Dodwad V, Puri N. Association of interleukin-1 α (-889) gene polymorphism in patients with generalized aggressive and chronic periodontitis.Dent Res J (Isfahan). 2015 Jan-Feb; 12(1): 76–82.10.4103/1735-3327.150338433697625709679]Search in Google Scholar
[8. Paster BJ, Boches SK, Galvin JL, Ericson RE, Lau CN, Levanos VA, Sahasrabudhe A, Dewhirst FE. Bacterial diversity in human subgingival plaque. J Bacteriol 2001; 183: 3770–3783. [PMC free article][PubMed]10.1128/JB.183.12.3770-3783.20019525511371542]Search in Google Scholar
[9. Shusterman A, Salyma Y, Nashef A, Soller M, Wilensky A, Mott R, Weiss EI, Houri-Haddad Y, Iraqi FA.Genotype is an important determinant factor of host susceptibility to periodontitis in the Collaborative Cross and inbred mouse populations.BMC Genet. 2013 Aug 9; 14: 68. doi: 10.1186/1471-2156-14-6810.1186/1471-2156-14-68375120223937452]Open DOISearch in Google Scholar
[10. Mcleod D. A practical approach to the diagnosis and treatment of periodontal disease. J Am Dent Assoc. 2000; 131(N4): 483–91.10.14219/jada.archive.2000.020510770011]Search in Google Scholar
[11. Li J, Helmerhorst EJ, Leone CW, Troxler RF, Yaskell T, Haffajee AD, Socransky SS, Oppenheim FG. Identification of early microbial colonizers in human dental biofilm. J Appl Microbiol 2004; 97: 1311–1318.[PubMed]10.1111/j.1365-2672.2004.02420.x]Open DOISearch in Google Scholar
[12. Mancl KA, Kirsner RS, Ajdic D. Wound biofilms: lessons learned from oral biofilms.Wound Repair Regen. 2013 May-Jun; 21(3): 352–62. doi: 10.1111/wrr.12034. Epub 2013. Apr 1. Review.10.1111/wrr.12034.Epub2013.Apr1.]Open DOISearch in Google Scholar
[13. Kawada M, Yoshida A, Suzuki N, Nakano Y, Saito T, Oho T, Koga T. Prevalence of Porphyromonas gingivalis in relation to periodontal status assessed by real-time PCR. Oral Microbiol Immunol 2004; 19: 289–292. [PubMed]10.1111/j.1399-302X.2004.00154.x]Search in Google Scholar
[14. Benso B. Virulence factors associated with Aggregatibacter actinomycetemcomitans and their role in promoting periodontal diseases. Virulence. 2017 Feb 17; 8(2): 111–114. doi: 10.1080/21505594.2016.1235128. Epub 2016 Sep 13.]Search in Google Scholar
[15. Takeuchi Y, Umea M, Sakamoto M, Benn Y, Huang Y, Ishikawa I. Treponema Socranskii, Treponema denticola and Porphyromonas gingivalis are associated with severity of periodontal tissue destruction J Periodontol. 2001; 72(10); 1354–6310.1902/jop.2001.72.10.1354]Search in Google Scholar
[16. Fenollar F, Raoult D. APMIS. 2004 Nov-Dec; 112(11-12): 785–807. Molecular genetic methods for the diagnosis of fastidious microorganisms.[APMIS. 2004]]Search in Google Scholar
[17. Veal DA, Deere D, Ferrari B, Piper J, Attfield PV. Fluorescence staining and flow cytometry for monitoring microbial cells. J Immunol Methods 2000; 243: 191–210. [PubMed]10.1016/S0022-1759(00)00234-9]Search in Google Scholar
[18. Morikawa M, Chiba T, Tomii N, Sato S, Takahashi Y, Konishi K, Numabe Y, Iwata K, Imai K.Comparative analysis of putative periodontopathic bacteria by multiplex polymerase chain reaction. J Periodontal Res. 2008 Jun; 43(3): 268–74. doi: 10.1111/j.1600-0765.2007.01025.x.10.1111/j.1600-0765.2007.01025.x18447853]Open DOISearch in Google Scholar
[19. Welsh AK, McLean RJ.Characterization of bacteria in mixed biofilm communities using denaturing gradient gel electrophoresis (DGGE). Curr Protoc Microbiol. 2007 Feb; Chapter 1:Unit 1E.1. doi: 10.1002/9780471729259.mc01e01s410.1002/9780471729259.mc01e01s418770601]Open DOISearch in Google Scholar
[20. Chatzopoulos GS, Doufexi AE, Kalogirou F.Association of susceptible genotypes to periodontal disease with the clinical outcome and tooth survival after non-surgical periodontal therapy: A systematic review and meta-analysis.Med Oral Patol Oral Cir Bucal. 2016 Jan 1; 21(1): e14-29. Review.10.4317/medoral.20638476574526595831]Search in Google Scholar
[21. Morillo JM, Lau L, Sanz M, Herrera D, Martin C, Silva A. Quantitative real-time polymerase chain reaction based on single copy gene sequence for detection of periodontal pathogens. J Clin Periodontol2004; 31: 1054–1060. [PubMed]10.1111/j.1600-051x.2004.00608.x15560805]Open DOISearch in Google Scholar
[22. Wolff D, Staehle HJ, Wolff B.Amplification of minute amounts of oral bacterial DNA for real-time quantitative PCR analysis.Caries Res. 2010; 44(5): 498–504. doi: 10.1159/000320161. Epub 2010 Sep 2410.1159/000320161.Epub2010Sep24]Open DOISearch in Google Scholar
[23. Nadkarni MA, Martin FE, Hunter N, Jacques NA. Methods for optimizing DNA extraction before quantifying oral bacterial numbers by real-time PCR.FEMS Microbiol Lett. 2009 Jul; 296(1): 45–51. doi: 10.1111/j.1574-6968.2009.01629.x. Epub 2009 May 7.10.1111/j.1574-6968.2009.01629.x.Epub20097]Open DOISearch in Google Scholar
[24. Suzuki N, Nakano Y, Yoshida A, Yamashita Y, Kiyoura Y. J Clin Microbiol. 2004 Aug; 42(8): 3827–30. Real-time TaqMan PCR for quantifying oral bacteria during biofilm formation. [J Clin Microbiol. 2004]]Search in Google Scholar
[25. Price RR, Viscount HB, Stanley MC, Leung KP. Targeted profiling of oral bacteria in human saliva and in vitro biofilms with quantitative real-time PCR. Biofouling. 2007; 23(3-4): 203–13.10.1080/08927010701251169]Open DOISearch in Google Scholar
[26. Park SN, Lim YK, Kook JK. Development of quantitative real-time PCR primers for detecting 42 oral bacterial species.Arch Microbiol. 2013 Jul; 195(7): 473–82. doi: 10.1007/s00203-013-0896-4. Epub 2013 May 2110.1007/s00203-013-0896-4.Epub201321]Open DOISearch in Google Scholar
[27. Milićević R, Brajović G, Nikolić-Jakoba N, Popović B, Pavlica D, Leković V, Milasin J. [Identification of periodontopathogen microorganisms by PCR technique]. Srp Arh Celok Lek. 2008 Sep-Oct; 136(9–10): 476-80. Serbian.10.2298/SARH0810476M]Search in Google Scholar
[28. Grce M.Molecular diagnosis of oral infections]. Acta Med Croatica. 2013 Dec; 67(5): 425–32. Review. Croatian]Search in Google Scholar
[29. Deng DM, Crielaard W.[Microbial genetics. New possibilities for the prevention and treatment of (oral) infections].Ned Tijdschr Tandheelkd. 2008 Feb; 115(2): 93–9. Review. Dutch.]Search in Google Scholar
[30. Boutaga K, van Winkelhoff AJ, Vandenbroucke-Grauls CM, Savelkoul PH. The additional value of real-time PCR in the quantitative detection of periodontal pathogens. J Clin Periodontol. 2006 Jun; 33(6): 427–33.10.1111/j.1600-051X.2006.00925.x]Open DOISearch in Google Scholar
[31. Cutress TW, Ainamo J, Sardo-Infirri J. The community periodontal index of treatment needs (CPITN) procedure for population groups and individuals. Int Dent J. 1987; 37: 222–233. [PubMed]]Search in Google Scholar
[32. Lang NP, Joss A, Orsanic T, Gusberti FA, Siegrist BE. Bleeding on probing. A predictor for the progression of periodontal disease? J Clin Periodontol. 1986; 13: 590–596. doi: 10.1111/j.1600-051X.1986.tb00852.x. [PubMed] [CrossRef]10.1111/j.1600-051X.1986.tb00852.x.[PubMed][CrossRef3489010]Open DOISearch in Google Scholar
[33. Yoshida A, Suzuki N, Nakano Y, Oho T, Kawada M, Koga T. Development of a 5′ fluorogenic nuclease-based real-time PCR assay for quantitative detection of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. J Clin Microbiol 2003; 41: 863–866. [PubMed]10.1128/JCM.41.2.863-866.200314971712574302]Open DOISearch in Google Scholar
[34. Yoshida A, Suzuki N, Nakano Y, Kawada M, Oho T, Koga T. Development of a 5′ nuclease-based real-time PCR assay for quantitative detection of cariogenic dental pathogens Streptococcus mutans and Streptococcus sobrinus. J Clin Microbiol 2003; 41: 4438–4441. [PubMed]10.1128/JCM.41.9.4438-4441.200319379612958287]Search in Google Scholar
[35. Suzuki N, Yoshida A, Saito T, Kawada M, Nakano Y. Quantitative microbiological study of subgingival plaque by real-time PCR shows correlation between levels of Tannerella forsythensis and Fusobacterium spp. J Clin Microbiol 2004; 42: 2255–2257. [PubMed]1513120510.1128/JCM.42.5.2255-2257.200440465115131205]Search in Google Scholar
[36. Yoshida A, Kawada M, Suzuki N, Nakano Y, Oho T, Saito T, Yamashita Y. TaqMan real-time polymerase chain reaction assay for the correlation of Treponema denticola numbers with the severity of periodontal disease. Oral Microbiol Immunol 2004; 19: 196–200. [PubMed]10.1111/j.0902-0055.2004.00142.x15107072]Search in Google Scholar
[37. Kornman KS, Polverini PJ.Clinical application of genetics to guide prevention and treatment of oral diseases.Clin Genet. 2014 Jul; 86(1): 44–9. doi: 10.1111/cge.12396. Epub 2014 May 10. Review10.1111/cge.12396.Epub201410.]Open DOISearch in Google Scholar
[38. Cantore S, Mirgaldi R, Ballini A, Coscia MF, Scacco S, Papa F, Inchingolo F, Dipalma G, De Vito D.Cytokine gene polymorphisms associate with microbiogical agents in periodontal disease: our experience.Int J Med Sci. 2014 May 1; 11(7): 674–9. doi: 10.7150/ijms.6962.eCollection 201410.7150/ijms.6962.eCollection2014]Open DOISearch in Google Scholar
[39. Atanasovska-Stojanovska A, Popovska M, Trajkov D, Spiroski M IL1 cluster gene polymorphisms in Macedonian patients with chronic periodontitis Bratisl Lek Listy 2013; 114 (7)376 – 381DOI: 10.4149/BLL201310.4149/BLL2013]Open DOISearch in Google Scholar
[40. Marsh PD. Microbial Ecology of Dental Plaque and its Significance in Health and Disease Advances in Dental Research 8(2): 263–71 · August 1994 [PubMed]10.1177/089593749400800220017865085]Search in Google Scholar
[41. Nagihan Bostanci, Thomas Thurnheer, Joseph Aduse-Opoku, Michael A. Curtis, Annelies S. Zinkernagel, Georgios N. Belibasakis. Porphyromonas gingivalis Regulates TREM-1 in Human Polymorphonuclear Neutrophils via Its Gingi-pains.Plos.org/plosone/article?id=10.1371/journal;2013]Search in Google Scholar
[42. D. Ready, F. D’Aiuto, D. A. Spratt, J. Suvan, M. S. Tonetti, and M. Wilson. Disease Severity Associated with Presence in Subgingival Plaque of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Tannerella forsythia, Singly or in Combination, as Detected by Nested Multiplex PCR. J Clin Microbiol. 2008 Oct; 46(10): 3380–3383.1870166010.1128/JCM.01007-08256610118701660]Search in Google Scholar