<abstract xmlns="http://www.w3.org/1999/xhtml">

<italic>Introduction:</italic> The doping of high Z nanoparticles into the tumor tissue increases the therapeutic efficiency of radiotherapy called nanoparticle enhanced radiotherapy (NERT). In the present study, we are identifying the effective types of radiation and effective doping concentration of bismuth radiosensitizer for NERT application by analyzing effective atomic number (Zeff) and photon buildup factor (PBF) of bismuth (Bi) doped soft tissue for the photon, electron, proton, alpha particle, and carbon ion interactions.
<italic>Material and methods:</italic> The direct method was used for the calculation of Zeff for photon and electron beams (10 keV-30 MeV). The phy-X/ZeXTRa software was utilized for the particle beams such as proton, alpha particle, and carbon ions (1-15 MeV). Bismuth doping concentrations of 5, 10, 15, 20, 25 and 30 mg/g were considered. The PBF was calculated over 15 keV-15 MeV energies using phy-X/PSD software.
<italic>Results:</italic> The low energy photon (&lt;100 keV) interaction with a higher concentration of Bi dopped tissue gives the higher values of Zeff. The Zeff increased with the doping concentration of bismuth for all types of radiation. The Zeff was dependent on the type of radiation, the energy of radiation, and the concentration of Bi doping. The particle beams such as electron, proton, alpha particle, and carbon ion interaction gives the less values of Zeff has compared to photon beam interaction. On the other hand, the photon buildup factor values were decreased while increasing the Bi doping concentration.
<italic>Conclusions:</italic> According to Zeff and PBF, the low energy photon and higher concentration of radiosensitizer are the most effective for nanoparticle enhanced radiotherapy application. Based on the calculated values of Zeff, the particle beams such as electron, proton, alpha particle, and carbon ions were less effective for NERT application. The presented values of Zeff and PBF are useful for the radiation dosimetry in NERT.
</abstract>

Introduction: The doping of high Z nanoparticles into the tumor tissue increases the therapeutic efficiency of radiotherapy called nanoparticle enhanced radiotherapy (NERT). In the present study, we are identifying the effective types of radiation and effective doping concentration of bismuth radiosensitizer for NERT application by analyzing effective atomic number (Zeff) and photon buildup factor (PBF) of bismuth (Bi) doped soft tissue for the photon, electron, proton, alpha particle, and carbon ion interactions.
Material and methods: The direct method was used for the calculation of Zeff for photon and electron beams (10 keV-30 MeV). The phy-X/ZeXTRa software was utilized for the particle beams such as proton, alpha particle, and carbon ions (1-15 MeV). Bismuth doping concentrations of 5, 10, 15, 20, 25 and 30 mg/g were considered. The PBF was calculated over 15 keV-15 MeV energies using phy-X/PSD software.
Results: The low energy photon (<100 keV) interaction with a higher concentration of Bi dopped tissue gives the higher values of Zeff. The Zeff increased with the doping concentration of bismuth for all types of radiation. The Zeff was dependent on the type of radiation, the energy of radiation, and the concentration of Bi doping. The particle beams such as electron, proton, alpha particle, and carbon ion interaction gives the less values of Zeff has compared to photon beam interaction. On the other hand, the photon buildup factor values were decreased while increasing the Bi doping concentration.
Conclusions: According to Zeff and PBF, the low energy photon and higher concentration of radiosensitizer are the most effective for nanoparticle enhanced radiotherapy application. Based on the calculated values of Zeff, the particle beams such as electron, proton, alpha particle, and carbon ions were less effective for NERT application. The presented values of Zeff and PBF are useful for the radiation dosimetry in NERT.

Effective atomic number and photon buildup factor of bismuth doped tissue for photon and particles beam interaction

Polish Journal of Medical Physics and Engineering

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Introduction: The doping of high Z nanoparticles into the tumor tissue increases the therapeutic efficiency of radiotherapy called nanoparticle enhanced...

Effective atomic number and photon buildup factor of bismuth doped tissue for photon and particles beam interaction

Publié en ligne: 29 mars 2022

Pages: 37 - 51

Reçu: 14 mai 2021

Accepté: 12 déc. 2021

DOI: https://doi.org/10.2478/pjmpe-2022-0005

Mots clés
effective atomic number, photon buildup factor, bismuth, soft tissue

© 2022 K Srinivasan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Effective atomic number and photon buildup factor of bismuth doped tissue for photon and particles beam interaction

Publié en ligne: 29 mars 2022

Pages: 37 - 51

Reçu: 14 mai 2021

Accepté: 12 déc. 2021

DOI: https://doi.org/10.2478/pjmpe-2022-0005

Mots cléseffective atomic number, photon buildup factor, bismuth, soft tissue

© 2022 K Srinivasan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
effective atomic number, photon buildup factor, bismuth, soft tissue