<abstract xmlns="http://www.w3.org/1999/xhtml">New five ciprofloxacin (CIP) complexes of dioxouranium(II), oxozirconium(II), zirconium(IV), oxovanadium(II) and vanadium(IV) in the proportion 1:2 have been prepared using CIP as a drug chelate with UO2(NO3)2. 6H2O, ZrOCl2. 8H2O, ZrCl4, VOSO4. xH2O and V2O5 respectively. The CIP complexes have been characterized based on the elemental analysis, molar conductance, magnetic, (FTIR &amp; 1HNMR) spectral and thermal studies. The molar conductance studies of the synthesized complexes in DMSO solvent with concentration of 10–3 M indicate their non-electrolytic properties. At room temperature, the magnetic moment measurements revealed a diamagnetic behavior for all CIP prepared complexes. The different formulas of the new complexes can be represented as [UO2(CIP)2(NO3)2] (<bold>I</bold>), [VO(CIP)2(SO4)(H2O)] (<bold>II</bold>), [V2(O)(O2)2(CIP)2] (<bold>III</bold>), [Zr(O)(CIP)2(Cl)2] (<bold>IV</bold>), and [Zr(CIP)2(Cl)4] (<bold>V</bold>). The thermal analysis data of the complexes indicates the absence of coordinated water molecules except for vanadyl(II) complex (<bold>II</bold>). The CIP chelate is a uni-dentate ligand coordinated to the mentioned metal ion through terminal piperazinyl nitrogen. The transmission electron microscopy (TEM) investigation confirms the nano-structured form of the complexes.</abstract>

New five ciprofloxacin (CIP) complexes of dioxouranium(II), oxozirconium(II), zirconium(IV), oxovanadium(II) and vanadium(IV) in the proportion 1:2 have been prepared using CIP as a drug chelate with UO2(NO3)2. 6H2O, ZrOCl2. 8H2O, ZrCl4, VOSO4. xH2O and V2O5 respectively. The CIP complexes have been characterized based on the elemental analysis, molar conductance, magnetic, (FTIR & 1HNMR) spectral and thermal studies. The molar conductance studies of the synthesized complexes in DMSO solvent with concentration of 10–3 M indicate their non-electrolytic properties. At room temperature, the magnetic moment measurements revealed a diamagnetic behavior for all CIP prepared complexes. The different formulas of the new complexes can be represented as [UO2(CIP)2(NO3)2] (I), [VO(CIP)2(SO4)(H2O)] (II), [V2(O)(O2)2(CIP)2] (III), [Zr(O)(CIP)2(Cl)2] (IV), and [Zr(CIP)2(Cl)4] (V). The thermal analysis data of the complexes indicates the absence of coordinated water molecules except for vanadyl(II) complex (II). The CIP chelate is a uni-dentate ligand coordinated to the mentioned metal ion through terminal piperazinyl nitrogen. The transmission electron microscopy (TEM) investigation confirms the nano-structured form of the complexes.

Synthesis, spectroscopic and thermogravimetric interpretations of UO2(II), ZrO(II), Zr(IV), VO(II) and V(V) ciprofloxacin antibiotic drug complexes

Department of Chemistry, College of Science

Princess Nourah Bint Abdulrahman University

Polish Journal of Chemical Technology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Synthesis, spectroscopic and thermogravimetric interpretations of UO(II), ZrO(II), Zr(IV), VO(II) and V(V) ciprofloxacin antibiotic drug complexes

New five ciprofloxacin (CIP) complexes of dioxouranium(II), oxozirconium(II), zirconium(IV), oxovanadium(II) and vanadium(IV) in the proportion 1:2 have been...

Synthesis, spectroscopic and thermogravimetric interpretations of UO₂(II), ZrO(II), Zr(IV), VO(II) and V(V) ciprofloxacin antibiotic drug complexes

Publié en ligne: 05 mai 2021

Pages: 45 - 52

DOI: https://doi.org/10.2478/pjct-2021-0007

Mots clés
ciprofloxacin, complexation, FTIR, diamagnetic, TEM, nanoscale

© 2021 Lamia A. Albedair, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Synthesis, spectroscopic and thermogravimetric interpretations of UO2(II), ZrO(II), Zr(IV), VO(II) and V(V) ciprofloxacin antibiotic drug complexes

Publié en ligne: 05 mai 2021

Pages: 45 - 52

DOI: https://doi.org/10.2478/pjct-2021-0007

Mots clésciprofloxacin, complexation, FTIR, diamagnetic, TEM, nanoscale

© 2021 Lamia A. Albedair, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Synthesis, spectroscopic and thermogravimetric interpretations of UO₂(II), ZrO(II), Zr(IV), VO(II) and V(V) ciprofloxacin antibiotic drug complexes

Mots clés
ciprofloxacin, complexation, FTIR, diamagnetic, TEM, nanoscale