<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The wide distribution of mycotoxins, including aflatoxin B1 and ochratoxin A, in the environment and their influence on living organisms make them an interesting research problem. Numerous complications of intoxication with these substances are known, however, particular attention is paid to the effects on the skeletal and nervous systems. The inflammatory effect, presented by the increase in the concentration of cytokines - IL-6 and TNF-α may influence the immune dysregulation present in bone metabolism disorders, as well as in neurodegeneration. Mycotoxins also contribute to osteodegeneration by modifying vitamin D metabolism. Interestingly, and still unexplored, is the mechanism of intrauterine influence on bone metabolism and neurodegeneration processes. Understanding the above mechanisms may help in monitoring the toxic effects of intoxication with these toxins. It can also help develop methods of therapy for poisoning with this compound, in animals and humans.</p>
</abstract>

The wide distribution of mycotoxins, including aflatoxin B1 and ochratoxin A, in the environment and their influence on living organisms make them an interesting research problem. Numerous complications of intoxication with these substances are known, however, particular attention is paid to the effects on the skeletal and nervous systems. The inflammatory effect, presented by the increase in the concentration of cytokines - IL-6 and TNF-α may influence the immune dysregulation present in bone metabolism disorders, as well as in neurodegeneration. Mycotoxins also contribute to osteodegeneration by modifying vitamin D metabolism. Interestingly, and still unexplored, is the mechanism of intrauterine influence on bone metabolism and neurodegeneration processes. Understanding the above mechanisms may help in monitoring the toxic effects of intoxication with these toxins. It can also help develop methods of therapy for poisoning with this compound, in animals and humans.

Ochratoxin A and Aflatoxin B1 as Factors of Bone Damage and Neurodegeneration Through the Influence on the Immunomodulation Processes of TNF-α and IL-6 Concentrations

Department of Animal Physiology, Faculty of Veterinary Medicine

Toxicology Clinic, Clinical Department of Toxicology and Cardiology

Stefan Wyszyński Regional Specialist Hospital, Medical University of Lublin

John Paul II University in Biała Podlaska

Jozef Pilsudski University of Physical Education in Warsaw

Faculty of Physical Education in Biała Podlaska

Department of Epidemiology and Public Health

Polish Hyperbaric Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The wide distribution of mycotoxins, including aflatoxin B1 and ochratoxin A, in the environment and their influence on living organisms make them an...

Ochratoxin A and Aflatoxin B1 as Factors of Bone Damage and Neurodegeneration Through the Influence on the Immunomodulation Processes of TNF-α and IL-6 Concentrations

Publié en ligne: 10 nov. 2023

Pages: 61 - 72

Reçu: 25 févr. 2022

Accepté: 09 mars 2022

DOI: https://doi.org/10.2478/phr-2022-0017

Mots clés
bone metabolism, bone development, bone remodelling, mycotoxin, aflatoxin B1, ochratoxin A, neurodegeneration

© 2022 Agnieszka Radzka-Pogoda et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Ochratoxin A and Aflatoxin B1 as Factors of Bone Damage and Neurodegeneration Through the Influence on the Immunomodulation Processes of TNF-α and IL-6 Concentrations

Publié en ligne: 10 nov. 2023

Pages: 61 - 72

Reçu: 25 févr. 2022

Accepté: 09 mars 2022

DOI: https://doi.org/10.2478/phr-2022-0017

Mots clésbone metabolism, bone development, bone remodelling, mycotoxin, aflatoxin B1, ochratoxin A, neurodegeneration

© 2022 Agnieszka Radzka-Pogoda et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
bone metabolism, bone development, bone remodelling, mycotoxin, aflatoxin B1, ochratoxin A, neurodegeneration