<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Benzimidazoles, which interfere with the complex life cycle of worms, are essential in the treatment of helminthiasis. Four benzimidazole antihelmintics have been used in human therapy: albendazole, mebendazole, thiabendazole, triclabendazole. The history, representatives, synthesis, physicochemical properties, structure-activity relationships of anthelmintic benzimidazoles are presented in the review, as well as the pharmacological properties and mechanism of action of these agents.</p>
<p>In the last decade, benzimidazole carbamate-structured anthelmintics have also been studied for their antitumor activity.</p>
</abstract>

Benzimidazoles, which interfere with the complex life cycle of worms, are essential in the treatment of helminthiasis. Four benzimidazole antihelmintics have been used in human therapy: albendazole, mebendazole, thiabendazole, triclabendazole. The history, representatives, synthesis, physicochemical properties, structure-activity relationships of anthelmintic benzimidazoles are presented in the review, as well as the pharmacological properties and mechanism of action of these agents.
In the last decade, benzimidazole carbamate-structured anthelmintics have also been studied for their antitumor activity.

Chemical and pharmacological characterization of anthelmintic benzimidazoles

„George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș

Bulletin of Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Chemical and pharmacological characterization of anthelmintic benzimidazoles"}

Benzimidazoles, which interfere with the complex life cycle of worms, are essential in the treatment of helminthiasis. Four benzimidazole antihelmintics have...

Chemical and pharmacological characterization of anthelmintic benzimidazoles

Publié en ligne: 31 oct. 2022

Pages: 88 - 96

DOI: https://doi.org/10.2478/orvtudert-2021-0013

Mots clés
benzimidazole, anthelmintic, analytics, mechanism of action, pharmacokinetics

© 2021 Kelemen Hajnal et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Chemical and pharmacological characterization of anthelmintic benzimidazoles

Publié en ligne: 31 oct. 2022

Pages: 88 - 96

DOI: https://doi.org/10.2478/orvtudert-2021-0013

Mots clésbenzimidazole, anthelmintic, analytics, mechanism of action, pharmacokinetics

© 2021 Kelemen Hajnal et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
benzimidazole, anthelmintic, analytics, mechanism of action, pharmacokinetics