A Simple and Rapid LC-MS/MS Method for Determination of Dexamethasone in Bovine Milk

1. Cherlet, M,. De Baere, S., De Backer, P.J. (2004). Quantitative determination of dexamethasone in bovine milk by liquid chromatography-atmospheric pressure chemical ionizationtandem mass spectrometry. J Chromatogr B. 805(1): 57–65. https://doi.org/10.1016/j.jchromb.2004.02.015 PMid:1511354010.1016/j.jchromb.2004.02.015Search in Google Scholar

2. Van Den Hauwe, O., Schneider, M., Sahin, A., Van Peteghem, C.H., Naegeli, H. (2003). Immunochemical screening and liquid chromatographic−tandem mass spectrometric confirmation of drug residues in edible tissues of calves injected with a therapeutic dose of the synthetic glucocorticoids dexamethasone and flumethasone. J Agric Food Chem. 51(1): 326–330. https://doi.org/10.1021/jf020533m PMid:1250242810.1021/jf020533mSearch in Google Scholar

3. Ferranti, C., Famele, M., Palleschi, L., Bozzetta, E., Pezzolato, M., Draisci, R. (2013). Excretion profile of corticosteroids in bovine urine compared with tissue residues after therapeutic and growthpromoting administration of dexamethasone. Steroids 78(9): 803–812. https://doi.org/10.1016/j.steroids.2013.05.002 PMid:2368452610.1016/j.steroids.2013.05.002Search in Google Scholar

4. The European Union. Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. Off J Eur Union L 15:1–72.Search in Google Scholar

5. De Wasch, K., De Brabander, H., Courtheyn, D., Van Peteghem, C. (1998). Detection of corticosteroids in injection sites and cocktails by MSn. Analyst 123(12): 2415–2422. https://doi.org/10.1039/a804932g PMid:1043527110.1039/a804932gSearch in Google Scholar

6. Hidalgo, O.H., Lopez, M.J., Carazo, E.A., Larrea, MSA., Reuvers, TBA. (2003). Determination of dexamethasone in urine by gas chromatography with negative chemical ionization mass spectrometry. J Chromatogr B. 788(1): 137–146. https://doi.org/10.1016/S1570-0232(02)01039-510.1016/S1570-0232(02)01039-5Search in Google Scholar

7. McDonald, M., Granelli, K., Sjöberg, P. (2007). Rapid multi-residue method for the quantitative determination and confirmation of glucocorticosteroids in bovine milk using liquid chromatography-electrospray ionization-tandem mass spectrometry. Anal Chim Acta. 588(1): 20–25. https://doi.org/10.1016/j.aca.2007.01.075 PMid:1738678910.1016/j.aca.2007.01.075Search in Google Scholar

8. Kumar, V., Mostafa, S., Kayo, M.V., Goldberg, E.P., Derendorf, H. (2006). HPLC determination of dexamethasone in human plasma and its application to an in vitro release study from endovascular stents. Pharmazie 61(11): 908–911.Search in Google Scholar

9. Li, C., Wu, Y., Yang, T., Zhang, Y. (2010). Rapid simultaneous determination of dexamethasone and betamethasone in milk by liquid chromatography tandem mass spectrometry with isotope dilution. J Chromatogr A. 1217(3): 411–414. https://doi.org/10.1016/j.chroma.2009.12.015 PMid:2001550310.1016/j.chroma.2009.12.015Search in Google Scholar

10. Croes, K., Goeyens, L., Baeyens, W., Van Loco, J., Impens, S. (2009). Optimization and validation of a liquid chromatography tandem mass spectrometry (LC/MSn) method for analysis of corticosteroids in bovine liver: evaluation of Keyhole Limpet beta-glucuronidase/sulfatase enzyme extract. J Chromatogr B Analyt Technol Biomed Life Sci. 877(7): 635–644. https://doi.org/10.1016/j.jchromb.2009.01.028 PMid:1921131310.1016/j.jchromb.2009.01.028Search in Google Scholar

11. Commission Decision of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results (2002/657/EC). Off J Eur Commun L221:8–3.Search in Google Scholar

12. Aerts, M.M.L., Hogenboom, A.C., Brinkman, U.A.T. (1995). Analytical strategies for the screening of veterinary drugs and their residues in edible products. J Chromatogr B Biomed Appl. 667(1): 1–40. https://doi.org/10.1016/0378-4347(95)00021-A10.1016/0378-4347(95)00021-ASearch in Google Scholar

13. Malone, E.M., Dowling, G., Elliott, C.T., Kennedy, D.G., Regan, L. (2009). Development of a rapid, multi-class method for the confirmatory analysis of anti-inflammatory drugs in bovine milk using liquid chromatography tandem mass spectrometry. J Chromatogr A. 1216(46): 8132–8140. https://doi.org/10.1016/j.chroma.2009.04.078 PMid:1946766410.1016/j.chroma.2009.04.07819467664Search in Google Scholar