Matrine and icariin can inhibit bovine viral diarrhoea virus replication by promoting type I interferon response in vitro

1. Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A.: Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001, 413, 732–738, doi: 10.1038/35099560. Alexopoulou L. Holt A.C. Medzhitov R. Flavell R.A. : Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3 . Nature 2001 , 413 , 732 – 738 , doi: 10.1038/35099560 . Open DOISearch in Google Scholar

2. Chen Y., Lin J., Zhao Y., Ma X., Yi H.: Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses. J Zhejiang Univ Sci B 2021, 22, 609–632, doi: 10.1631/jzus.B2000808. Chen Y. Lin J. Zhao Y. Ma X. Yi H. : Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses . J Zhejiang Univ Sci B 2021 , 22 , 609 – 632 , doi: 10.1631/jzus.B2000808 . Open DOISearch in Google Scholar

3. Cheng H., Xia B., Zhang L., Zhou F., Zhang Y.X., Ye M., Hu Z.G., Li J., Li J., Wang Z.L.: Matrine improves 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. Pharmacol Res 2006, 53, 202–208, doi: 10.1016/j.phrs.2005.11.001. Cheng H. Xia B. Zhang L. Zhou F. Zhang Y.X. Ye M. Hu Z.G. Li J. Li J. Wang Z.L. : Matrine improves 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice . Pharmacol Res 2006 , 53 , 202 – 208 , doi: 10.1016/j.phrs.2005.11.001 . Open DOISearch in Google Scholar

4. Cui Z., Wang Q., Li D., Zhao S., Zhang Q., Tan Y., Gong Q., Liu T., Shao J., Zhang S., Huang H., Wang J., Pei Z., Dong H., Wang K., Hu G.Li Z.: Icariin, Formononetin and Caffeic Acid Phenethyl Ester Inhibit Feline Calicivirus Replication In Vitro. Arch Virol 2021, 166, 2443–2450, doi: 10.1007/s00705-021-05107-w. Cui Z. Wang Q. Li D. Zhao S. Zhang Q. Tan Y. Gong Q. Liu T. Shao J. Zhang S. Huang H. Wang J. Pei Z. Dong H. Wang K. Hu G. Li Z. : Icariin, Formononetin and Caffeic Acid Phenethyl Ester Inhibit Feline Calicivirus Replication In Vitro . Arch Virol 2021 , 166 , 2443 – 2450 , doi: 10.1007/s00705-021-05107-w . Open DOISearch in Google Scholar

5. Fernandez G.A., Castro E.F., Rosas R.A., Fidalgo D.M., Adler N.S., Battini L., Espana de Marco M.J., Fabiani M., Bruno A.M., Bollini M., Cavallaro L.V.: Design and Optimization of Quinazoline Derivatives: New Non-nucleoside Inhibitors of Bovine Viral Diarrhea Virus. Front Chem 2020, 8, 590235, doi: 10.3389/fchem.2020.590235. Fernandez G.A. Castro E.F. Rosas R.A. Fidalgo D.M. Adler N.S. Battini L. Espana de Marco M.J. Fabiani M. Bruno A.M. Bollini M. Cavallaro L.V. : Design and Optimization of Quinazoline Derivatives: New Non-nucleoside Inhibitors of Bovine Viral Diarrhea Virus . Front Chem 2020 , 8 , 590235 , doi: 10.3389/fchem.2020.590235 . Open DOISearch in Google Scholar

6. Hu Z.L., Zhang J.P., Qian D.H., Lin W., Xie W.F., Zhang X.R., Chen W.Z.: Effects of matrine on mouse splenocyte proliferation and release of interleukin-1 and -6 from peritoneal macrophages in vitro. Zhongguo Yaoli Xuebao 1996, 17, 259–261, doi: 10.1016/0300-483X(96)03306-9. Hu Z.L. Zhang J.P. Qian D.H. Lin W. Xie W.F. Zhang X.R. Chen W.Z. : Effects of matrine on mouse splenocyte proliferation and release of interleukin-1 and -6 from peritoneal macrophages in vitro . Zhongguo Yaoli Xuebao 1996 , 17 , 259 – 261 , doi: 10.1016/0300-483X(96)03306-9 . Open DOISearch in Google Scholar

7. Jin J., Wang H., Hua X., Chen D., Huang C., Chen Z.: An outline for the pharmacological effect of icariin in the nervous system. Eur J Pharmacol 2019, 842, 20–32, doi: 10.1016/j.ejphar.2018.10.006. Jin J. Wang H. Hua X. Chen D. Huang C. Chen Z. : An outline for the pharmacological effect of icariin in the nervous system . Eur J Pharmacol 2019 , 842 , 20 – 32 , doi: 10.1016/j.ejphar.2018.10.006 . Open DOISearch in Google Scholar

8. Kato H., Oh S.W., Fujita T.: RIG-I-Like Receptors and Type I Interferonopathies. J Interferon Cytokine Res 2017, 37, 207–213, doi: 10.1089/jir.2016.0095. Kato H. Oh S.W. Fujita T. : RIG-I-Like Receptors and Type I Interferonopathies . J Interferon Cytokine Res 2017 , 37 , 207 – 213 , doi: 10.1089/jir.2016.0095 . Open DOISearch in Google Scholar

9. Kirkland P.D., Frost M.J., Finlaison D.S., King K.R., Ridpath J.F., Gu X.: Identification of a novel virus in pigs--Bungowannah virus: a possible new species of pestivirus. Virus Res 2007, 129, 26–34, doi: 10.1016/j.virusres.2007.05.002. Kirkland P.D. Frost M.J. Finlaison D.S. King K.R. Ridpath J.F. Gu X. : Identification of a novel virus in pigs--Bungowannah virus: a possible new species of pestivirus . Virus Res 2007 , 129 , 26 – 34 , doi: 10.1016/j.virusres.2007.05.002 . Open DOISearch in Google Scholar

10. Li X., Tang Z., Wen L., Jiang C., Feng Q.: Matrine: A review of its pharmacology, pharmacokinetics, toxicity, clinical application and preparation researches. J Ethnopharmacol 2021, 269, 113682, doi: 10.1016/j.jep.2020.113682. Li X. Tang Z. Wen L. Jiang C. Feng Q. : Matrine: A review of its pharmacology, pharmacokinetics, toxicity, clinical application and preparation researches . J Ethnopharmacol 2021 , 269 , 113682 , doi: 10.1016/j.jep.2020.113682 . Open DOISearch in Google Scholar

11. Li Y., Peng Z., Gao L., Song D.: Synthesis and biological evaluation of sophocarpinic acid derivatives as anti-HCV agents. Acta Pharm Sin B 2014, 4, 307–312, doi: 10.1016/j.apsb.2014.06.002. Li Y. Peng Z. Gao L. Song D. : Synthesis and biological evaluation of sophocarpinic acid derivatives as anti-HCV agents . Acta Pharm Sin B 2014 , 4 , 307 – 312 , doi: 10.1016/j.apsb.2014.06.002 . Open DOISearch in Google Scholar

12. Magkouras I., Matzener P., Rumenapf T., Peterhans E., Schweizer M.: RNase-dependent inhibition of extracellular, but not intracellular, dsRNA-induced interferon synthesis by Erns of pestiviruses. J Gen Virol 2008, 89, 2501–2506, doi: 10.1099/vir.0.2008/003749-0. Magkouras I. Matzener P. Rumenapf T. Peterhans E. Schweizer M. : RNase-dependent inhibition of extracellular, but not intracellular, dsRNA-induced interferon synthesis by Erns of pestiviruses . J Gen Virol 2008 , 89 , 2501 – 2506 , doi: 10.1099/vir.0.2008/003749-0 . Open DOISearch in Google Scholar

13. McNab F., Mayer-Barber K., Sher A., Wack A., O’Garra A.: Type I interferons in infectious disease. Nat Rev Immunol 2015, 15, 87–103, doi: 10.1038/nri3787. McNab F. Mayer-Barber K. Sher A. Wack A. O’Garra A. : Type I interferons in infectious disease . Nat Rev Immunol 2015 , 15 , 87 – 103 , doi: 10.1038/nri3787 . Open DOISearch in Google Scholar

14. Mishra N., Dubey R., Rajukumar K., Tosh C., Tiwari A., Pitale S. S., Pradhan H.K.: Genetic and antigenic characterization of bovine viral diarrhea virus type 2 isolated from indian goats (capra hircus). Vet Microbiol 2007, 124, 340–347, doi: 10.1016/j.vetmic.2007.04.023. Mishra N. Dubey R. Rajukumar K. Tosh C. Tiwari A. Pitale S. S. Pradhan H.K. : Genetic and antigenic characterization of bovine viral diarrhea virus type 2 isolated from indian goats (capra hircus) . Vet Microbiol 2007 , 124 , 340 – 347 , doi: 10.1016/j.vetmic.2007.04.023 . Open DOISearch in Google Scholar

15. Muller P.Y., Milton M.N.: The determination and interpretation of the therapeutic index in drug development. Nat Rev Drug Discov 2012, 11, 751–761, doi: 10.1038/nrd3801. Muller P.Y. Milton M.N. : The determination and interpretation of the therapeutic index in drug development . Nat Rev Drug Discov 2012 , 11 , 751 – 761 , doi: 10.1038/nrd3801 . Open DOISearch in Google Scholar

16. Peterhans E., Schweizer M.: BVDV: a pestivirus inducing tolerance of the innate immune response. Biologicals 2013, 41, 39–51, doi: 10.1016/j.biologicals.2012.07.006. Peterhans E. Schweizer M. : BVDV: a pestivirus inducing tolerance of the innate immune response . Biologicals 2013 , 41 , 39 – 51 , doi: 10.1016/j.biologicals.2012.07.006 . Open DOISearch in Google Scholar

17. Pinior B., Firth C.L., Richter V., Lebl K., Trauffler M., Dzieciol M., Hutter S.E., Burgstaller J., Obritzhauser W., Winter P., Kasbohrer A.: A systematic review of financial and economic assessments of bovine viral diarrhea virus (BVDV) prevention and mitigation activities worldwide. Prev Vet Med 2017, 137, 77–92, doi: 10.1016/j.prevetmed.2016.12.014. Pinior B. Firth C.L. Richter V. Lebl K. Trauffler M. Dzieciol M. Hutter S.E. Burgstaller J. Obritzhauser W. Winter P. Kasbohrer A. : A systematic review of financial and economic assessments of bovine viral diarrhea virus (BVDV) prevention and mitigation activities worldwide . Prev Vet Med 2017 , 137 , 77 – 92 , doi: 10.1016/j.prevetmed.2016.12.014 . Open DOISearch in Google Scholar

18. Ridpath J.F.: BVDV genotypes and biotypes: practical implications for diagnosis and control. Biologicals 2003, 31, 127–131, doi: 10.1016/s1045-1056(03)00028-9. Ridpath J.F. : BVDV genotypes and biotypes: practical implications for diagnosis and control . Biologicals 2003 , 31 , 127 – 131 , doi: 10.1016/s1045-1056(03)00028-9 . Open DOISearch in Google Scholar

19. Schmitz M.L., Kracht M., Saul V.V.: The intricate interplay between RNA viruses and NF-kappaB. Biochim Biophys Acta 2014, 1843, 2754–2764, doi: 10.1016/j.bbamcr.2014.08.004. Schmitz M.L. Kracht M. Saul V.V. : The intricate interplay between RNA viruses and NF-kappaB . Biochim Biophys Acta 2014 , 1843 , 2754 – 2764 , doi: 10.1016/j.bbamcr.2014.08.004 . Open DOISearch in Google Scholar

20. Shan Y., Tong Z., Jinzhu M., Yu L., Zecai Z., Chenhua W., Wenjing H., Siyu L., Nannan C., Siyu S., Tongtong B., Jiang H., Biaohui B., Xin J., Yulong Z., Zhanbo Z.: Bovine viral diarrhea virus NS4B protein interacts with 2CARD of MDA5 domain and negatively regulates the RLR-mediated IFN-beta production. Virus Res 2021, 302, 198471, doi: 10.1016/j.virusres.2021.198471. Shan Y. Tong Z. Jinzhu M. Yu L. Zecai Z. Chenhua W. Wenjing H. Siyu L. Nannan C. Siyu S. Tongtong B. Jiang H. Biaohui B. Xin J. Yulong Z. Zhanbo Z. : Bovine viral diarrhea virus NS4B protein interacts with 2CARD of MDA5 domain and negatively regulates the RLR-mediated IFN-beta production . Virus Res 2021 , 302 , 198471 , doi: 10.1016/j.virusres.2021.198471 . Open DOISearch in Google Scholar

21. Song L., Chen X., Mi L., Liu C., Zhu S., Yang T., Luo X., Zhang Q., Lu H.Liang X.: Icariin-induced inhibition of SIRT6/NF-kappaB triggers redox mediated apoptosis and enhances anti-tumor immunity in triple-negative breast cancer. Cancer Sci 2020, 111, 4242–4256, doi: 10.1111/cas.14648. Song L. Chen X. Mi L. Liu C. Zhu S. Yang T. Luo X. Zhang Q. Lu H. Liang X. : Icariin-induced inhibition of SIRT6/NF-kappaB triggers redox mediated apoptosis and enhances anti-tumor immunity in triple-negative breast cancer . Cancer Sci 2020 , 111 , 4242 – 4256 , doi: 10.1111/cas.14648 . Open DOISearch in Google Scholar

22. Stetson D.B., Medzhitov R.: Type I interferons in host defense. Immunity 2006, 25, 373–381, doi: 10.1016/j.immuni.2006.08.007. Stetson D.B. Medzhitov R. : Type I interferons in host defense . Immunity 2006 , 25 , 373 – 381 , doi: 10.1016/j.immuni.2006.08.007 . Open DOISearch in Google Scholar

23. Sun N., Wang Z.W., Wu C.H., Li E., He J.P., Wang S.Y., Hu Y.L., Lei H.M., Li H.Q.: Antiviral activity and underlying molecular mechanisms of Matrine against porcine reproductive and respiratory syndrome virus in vitro. Res Vet Sci 2014, 96, 323–327, doi: 10.1016/j.rvsc.2013.12.009. Sun N. Wang Z.W. Wu C.H. Li E. He J.P. Wang S.Y. Hu Y.L. Lei H.M. Li H.Q. : Antiviral activity and underlying molecular mechanisms of Matrine against porcine reproductive and respiratory syndrome virus in vitro . Res Vet Sci 2014 , 96 , 323 – 327 , doi: 10.1016/j.rvsc.2013.12.009 . Open DOISearch in Google Scholar

24. Tang Y., Li Y., Xin D., Chen L., Xiong Z., Yu X.: Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling. Bioengineered 2021, 12, 2984–2999, doi: 10.1080/21655979.2021.1943602. Tang Y. Li Y. Xin D. Chen L. Xiong Z. Yu X. : Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling . Bioengineered 2021 , 12 , 2984 – 2999 , doi: 10.1080/21655979.2021.1943602 . Open DOISearch in Google Scholar

25. Tian B., Cai D., He T., Deng L., Wu L., Wang M., Jia R., Zhu D., Liu M., Yang Q., Wu Y., Zhao X., Chen X., Zhang S., Huang J., Ou X., Mao S., Yu Y., Zhang L., Liu Y., Cheng A.: Isolation and selection of duck primary cells as pathogenic and innate immunologic cell models for duck plague virus. Front Immunol 2020, 10, 3131, doi: 10.3389/fimmu.2019.03131. Tian B. Cai D. He T. Deng L. Wu L. Wang M. Jia R. Zhu D. Liu M. Yang Q. Wu Y. Zhao X. Chen X. Zhang S. Huang J. Ou X. Mao S. Yu Y. Zhang L. Liu Y. Cheng A. : Isolation and selection of duck primary cells as pathogenic and innate immunologic cell models for duck plague virus . Front Immunol 2020 , 10 , 3131 , doi: 10.3389/fimmu.2019.03131 . Open DOISearch in Google Scholar

26. Uttenthal Å., Hoyer M., Grøndahl C., Houe H., van Maanen C., Rasmussen T.B., Larsen L.E.: Vertical transmission of bovine viral diarrhoea virus (BVDV) in mousedeer (Tragulus javanicus) and spread to domestic cattle. Arch Virol 2006, 151, 2377–2387, doi: 10.1007/s00705-006-0818-8. Uttenthal Å. Hoyer M. Grøndahl C. Houe H. van Maanen C. Rasmussen T.B. Larsen L.E. : Vertical transmission of bovine viral diarrhoea virus (BVDV) in mousedeer (Tragulus javanicus) and spread to domestic cattle . Arch Virol 2006 , 151 , 2377 – 2387 , doi: 10.1007/s00705-006-0818-8 . Open DOISearch in Google Scholar

27. Wang J., Yang G., Zhang L., Zhang J., Wang J., Zou Y., Wang J.: Berbamine hydrochloride inhibits bovine viral diarrhea virus replication via interfering in late-stage autophagy. Virus Res 2022, 321, 198905, doi: 10.1016/j.virusres.2022.198905. Wang J. Yang G. Zhang L. Zhang J. Wang J. Zou Y. Wang J. : Berbamine hydrochloride inhibits bovine viral diarrhea virus replication via interfering in late-stage autophagy . Virus Res 2022 , 321 , 198905 , doi: 10.1016/j.virusres.2022.198905 . Open DOISearch in Google Scholar

28. Wegelt A., Reimann I., Granzow H., Beer M.: Characterization and purification of recombinant bovine viral diarrhea virus particles with epitope-tagged envelope proteins. J Gen Virol 2011, 92, 1352–1357, doi: 10.1099/vir.0.029330-0. Wegelt A. Reimann I. Granzow H. Beer M. : Characterization and purification of recombinant bovine viral diarrhea virus particles with epitope-tagged envelope proteins . J Gen Virol 2011 , 92 , 1352 – 1357 , doi: 10.1099/vir.0.029330-0 . Open DOISearch in Google Scholar

29. Xiong W., Zhang W., Yuan W., Du H., Ming K., Yao F., Bai J., Chen Y., Liu J., Wang D., Hu Y., Wu Y.: Phosphorylation of Icariin Can Alleviate the Oxidative Stress Caused by the Duck Hepatitis Virus A through Mitogen-Activated Protein Kinases Signaling Pathways. Front Microbiol 2017, 8, 1850, doi: 10.3389/fmicb.2017.01850. Xiong W. Zhang W. Yuan W. Du H. Ming K. Yao F. Bai J. Chen Y. Liu J. Wang D. Hu Y. Wu Y. : Phosphorylation of Icariin Can Alleviate the Oxidative Stress Caused by the Duck Hepatitis Virus A through Mitogen-Activated Protein Kinases Signaling Pathways . Front Microbiol 2017 , 8 , 1850 , doi: 10.3389/fmicb.2017.01850 . Open DOISearch in Google Scholar

30. Yoneyama M., Kikuchi M., Natsukawa T., Shinobu N., Imaizumi T., Miyagishi M., Taira K., Akira S., Fujita T.: The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 2004, 5, 730–737, doi: 10.1038/ni1087. Yoneyama M. Kikuchi M. Natsukawa T. Shinobu N. Imaizumi T. Miyagishi M. Taira K. Akira S. Fujita T. : The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses . Nat Immunol 2004 , 5 , 730 – 737 , doi: 10.1038/ni1087 . Open DOISearch in Google Scholar

31. Zhang M.F., Shen Y.Q.: Research Progress on Clinical Pharmacological Effects of Matrine Alkaloids against Hepatitis B Virus. Anti-infective Pharm (Chinese) 2018, 15, 1–6. Zhang M.F. Shen Y.Q. : Research Progress on Clinical Pharmacological Effects of Matrine Alkaloids against Hepatitis B Virus . Anti-infective Pharm (Chinese) 2018 , 15 , 1 – 6 . Search in Google Scholar