<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jvetres-2022-0011_s_005">
<h3>Introduction</h3>
<p>Nontuberculous mycobacteria (NTM) are increasingly recognised as causative agents of opportunistic infections in humans for which effective treatment is challenging. There is very little information on the prevalence of NTM drug resistance in Poland. This study was aimed to evaluate the susceptibility to antibiotics of NTM, originally isolated from diseased ornamental fish.</p>
</sec>
<sec id="j_jvetres-2022-0011_s_006">
<h3>Material and Methods</h3>
<p>A total of 99 isolates were studied, 50 of them rapidly growing mycobacteria (RGM) (among which three-quarters were <italic>Mycobacterium chelonae</italic>, <italic>M. peregrinum</italic>, and <italic>M. fortuitum</italic> and the rest <italic>M. neoaurum</italic>, <italic>M. septicum</italic>, <italic>M. abscessus</italic>, <italic>M. mucogenicum</italic>, <italic>M. salmoniphilum</italic>, <italic>M saopaulense</italic>, and <italic>M. senegalense</italic>). The other 49 were slowly growing mycobacteria (SGM) isolates (among which only one was <italic>M. szulgai</italic> and the bulk <italic>M. marinum</italic> and <italic>M. gordonae</italic>). Minimum inhibitory concentrations for amikacin (AMK), kanamycin (KAN), tobramycin (TOB), doxycycline (DOX), ciprofloxacin (CIP), clarithromycin (CLR), sulfamethoxazole (SMX), isoniazid (INH) and rifampicin (RMP) were determined.</p></sec>
<sec id="j_jvetres-2022-0011_s_007">
<h3>Results</h3>
<p>The majority of the isolates were susceptible to KAN (95.95%: RGM 46.46% and SGM 49.49%), AMK (94.94%: RGM 45.45% and SGM 49.49%), CLR (83.83%: RGM 36.36% and SGM 47.47%), SMX (79.79%: RGM 30.30% and SMG 49.49%), CIP (65.65%: RGM 24.24% and SGM 41.41%), and DOX (55.55%: RGM 9.06% and SGM 46.46%). The majority were resistant to INH (98.98%: RGM 50.50% and SGM 48.48%) and RMP (96.96%: RGM 50.50% and SGM 46.46%).</p></sec>
<sec id="j_jvetres-2022-0011_s_008">
<h3>Conclusion</h3>
<p>The drug sensitivity of NTM varies from species to species. KAN, AMK, CLR and SMX were the most active against RGM isolates, and these same four plus DOX and CIP were the best drugs against SGM isolates.</p>
</sec>
</abstract>

Introduction
Nontuberculous mycobacteria (NTM) are increasingly recognised as causative agents of opportunistic infections in humans for which effective treatment is challenging. There is very little information on the prevalence of NTM drug resistance in Poland. This study was aimed to evaluate the susceptibility to antibiotics of NTM, originally isolated from diseased ornamental fish.


Material and Methods
A total of 99 isolates were studied, 50 of them rapidly growing mycobacteria (RGM) (among which three-quarters were Mycobacterium chelonae, M. peregrinum, and M. fortuitum and the rest M. neoaurum, M. septicum, M. abscessus, M. mucogenicum, M. salmoniphilum, M saopaulense, and M. senegalense). The other 49 were slowly growing mycobacteria (SGM) isolates (among which only one was M. szulgai and the bulk M. marinum and M. gordonae). Minimum inhibitory concentrations for amikacin (AMK), kanamycin (KAN), tobramycin (TOB), doxycycline (DOX), ciprofloxacin (CIP), clarithromycin (CLR), sulfamethoxazole (SMX), isoniazid (INH) and rifampicin (RMP) were determined.

Results
The majority of the isolates were susceptible to KAN (95.95%: RGM 46.46% and SGM 49.49%), AMK (94.94%: RGM 45.45% and SGM 49.49%), CLR (83.83%: RGM 36.36% and SGM 47.47%), SMX (79.79%: RGM 30.30% and SMG 49.49%), CIP (65.65%: RGM 24.24% and SGM 41.41%), and DOX (55.55%: RGM 9.06% and SGM 46.46%). The majority were resistant to INH (98.98%: RGM 50.50% and SGM 48.48%) and RMP (96.96%: RGM 50.50% and SGM 46.46%).

Conclusion
The drug sensitivity of NTM varies from species to species. KAN, AMK, CLR and SMX were the most active against RGM isolates, and these same four plus DOX and CIP were the best drugs against SGM isolates.

Antibiotic susceptibility of mycobacteria isolated from ornamental fish

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Antibiotic susceptibility of mycobacteria isolated from ornamental fish"}

Introduction
Nontuberculous mycobacteria (NTM) are increasingly recognised as causative agents of opportunistic infections in humans for which effective...

Antibiotic susceptibility of mycobacteria isolated from ornamental fish

Publié en ligne: 25 mars 2022

Pages: 69 - 76

Reçu: 03 sept. 2021

Accepté: 01 mars 2022

DOI: https://doi.org/10.2478/jvetres-2022-0011

Mots clés
spp, antimicrobial susceptibility, minimum inhibitory concentration, fish

© 2022 L. Guz, K. Puk., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Antibiotic susceptibility of mycobacteria isolated from ornamental fish

Publié en ligne: 25 mars 2022

Pages: 69 - 76

Reçu: 03 sept. 2021

Accepté: 01 mars 2022

DOI: https://doi.org/10.2478/jvetres-2022-0011

Mots clésspp, antimicrobial susceptibility, minimum inhibitory concentration, fish

© 2022 L. Guz, K. Puk., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
spp, antimicrobial susceptibility, minimum inhibitory concentration, fish