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Bodi D., Ronczka S., Gottschalk C., Behr N., Skibba A., Wagner M., Lahrssen-Wiederholt M., Preiss-Weigert A., These A.: Determination of pyrrolizidine alkaloids in tea, herbal drugs, and honey. Food Addit Contam Part A 2014, 31, 1886–1895.BodiD.RonczkaS.GottschalkC.BehrN.SkibbaA.WagnerM.Lahrssen-WiederholtM.Preiss-WeigertA.TheseA.Determination of pyrrolizidine alkaloids in tea, herbal drugs, and honey2014311886–189510.1080/19440049.2014.96433725222912Search in Google Scholar
Bolechová M., Čáslavský J., Pospíchalová M., Kosubová P.: UPLC–MS/MS method for determination of selected pyrrolizidine alkaloids in feed. Food Chem 2015, 170, 265–270.BolechováM.Čáslavský J., Pospíchalová M., Kosubová PUPLC–MS/MS method for determination of selected pyrrolizidine alkaloids in feed2015170265–27010.1016/j.foodchem.2014.08.07225306344Search in Google Scholar
Boppré M.: The ecological context of pyrrolizidine alkaloids in food, feed, and forage: an overview. Food Addit Contam Part A 2011, 28, 260–281.BoppréM.The ecological context of pyrrolizidine alkaloids in food, feed, and forage: an overview201128260–28110.1080/19440049.2011.55508521360373Search in Google Scholar
Boppré M., Colegate S.M., Edgar J.A.: Pyrrolizidine alkaloids of Echium vulgare honey found in pure pollen. J Agric Food Chem 2005, 53, 594–600.BoppréM.ColegateS.M.EdgarJ.A.Pyrrolizidine alkaloids of Echium vulgare honey found in pure pollen200553594–60010.1021/jf048453115686407Search in Google Scholar
Chen L., Mulder P.P.J., Louisse J., Peijnenburg A., Wesseling S., Rietjens I.M.C.M.: Risk assessment for pyrrolizidine alkaloids detection in (herbal) teas and plant supplements. Regul Toxicol Pharm 2017, 86, 292–302.ChenL.MulderP.P.J.LouisseJ.PeijnenburgA.WesselingS.RietjensI.M.C.M.Risk assessment for pyrrolizidine alkaloids detection in (herbal) teas and plant supplements201786292–30210.1016/j.yrtph.2017.03.01928347763Search in Google Scholar
Cramer L., Schiebel H.M., Ernst L., Beuerle T.: Pyrrolizidine alkaloids in the food chain: development, validation, and application of a new HPLC-ESI-MS/MS sum parameter method. J Agric Food Chem 2013, 61, 11382–11391.CramerL.SchiebelH.M.ErnstL.BeuerleT.Pyrrolizidine alkaloids in the food chain: development, validation, and application of a new HPLC-ESI-MS/MS sum parameter method20136111382–1139110.1021/jf403647u24245544Search in Google Scholar
Crews C., Berthiller F., Krska R.: Update on analytical methods for toxic pyrrolizidine alkaloids. Anal Bioanal Chem 2010, 396, 327–338.CrewsC.BerthillerF.KrskaR.Update on analytical methods for toxic pyrrolizidine alkaloids2010396327–33810.1007/s00216-009-3092-219763547Search in Google Scholar
de Nijs M., Mulder P.P.J., Klijnstra M.D., Driehuis F., Hoogenboom R.L.A.P.: Fate of pyrrolizidine alkaloids during processing of milk of cows treated with ragwort. Food Addit Contam Part A 2017, 34, 2212–2219.deNijs M.MulderP.P.J.KlijnstraM.D.DriehuisF.HoogenboomR.L.A.P.Fate of pyrrolizidine alkaloids during processing of milk of cows treated with ragwort2017342212–221910.1080/19440049.2017.136443228829252Search in Google Scholar
Danezis G.P., Anagnostopoulos C.J., Liapis K., Koupparis M.A.: Multi-residue analysis of pesticides, plant hormones, veterinary drugs, and mycotoxins using HILIC chromatography MS/MS in various food matrices. Anal Chimica Acta 2016, 942, 121–138.DanezisG.P.AnagnostopoulosC.J.LiapisK.KoupparisM.A.Multi-residue analysis of pesticides, plant hormones, veterinary drugs, and mycotoxins using HILIC chromatography MS/MS in various food matrices2016942121–13810.1016/j.aca.2016.09.01127720116Search in Google Scholar
Dreger M., Stanislawska M., Krajewska-Patan A., Mielcarek S., Mikolajczak P.L., Buchwald W.: Pyrrolizidine alkaloids - chemistry, biosynthesis, pathway, toxicity, safety, and perspectives of medicinal usage. Herba Pol 2009, 55, 127–147.DregerM.StanislawskaM.Krajewska-PatanA.MielcarekS.MikolajczakP.L.BuchwaldW.Pyrrolizidine alkaloids - chemistry, biosynthesis, pathway, toxicity, safety, and perspectives of medicinal usage200955127–147Search in Google Scholar
Dübecke A., Beckh G., Lüllmann C.: Pyrrolizidine alkaloids in honey and bee pollen. Food Addit Contam Part A 2011, 28, 348–358.DübeckeA.BeckhG.LüllmannC.Pyrrolizidine alkaloids in honey and bee pollen201128348–35810.1080/19440049.2010.54159421360377Search in Google Scholar
Edgar J.A., Colegate S.M., Boppre M., Molyneux R.J.: Pyrrolizidine alkaloids in food: a spectrum of potential health consequences. Food Addit Contam Part A 2011, 28, 308–324.EdgarJ.A.ColegateS.M.BoppreM.MolyneuxR.J.Pyrrolizidine alkaloids in food: a spectrum of potential health consequences201128308–32410.1080/19440049.2010.54752021360376Search in Google Scholar
Edgar J.A., Molyneux R.J., Colegate S.M.: Pyrrolizidine alkaloids: potential role in the aetiology of cancers, pulmonary hypertension, congenital anomalies, and liver disease. Chem Res Toxicol 2015, 28, 4–20.EdgarJ.A.MolyneuxR.J.ColegateS.M.Pyrrolizidine alkaloids: potential role in the aetiology of cancers, pulmonary hypertension, congenital anomalies, and liver disease2015284–2010.1021/tx500403t25483859Search in Google Scholar
Edgar J.A., Roeder E., Molyneaux R.J.: Honey from plants containing pyrrolizidine alkaloids: a potential threat to health. J Agric Food Chem 2002, 50, 2719–2730.EdgarJ.A.RoederE.MolyneauxR.J.Honey from plants containing pyrrolizidine alkaloids: a potential threat to health2002502719–273010.1021/jf011448211982390Search in Google Scholar
European Food Safety Authority, EFSA Panel on Contaminants in the Food Chain (CONTAM). Scientific opinion on pyrrolizidine alkaloids in food and feed. EFSA J 2011, 9:2406, 1–134.European Food Safety Authority, EFSA Panel on Contaminants in the Food Chain (CONTAM). Scientific opinion on pyrrolizidine alkaloids in food and feed2011924061–13410.2903/j.efsa.2011.2406Search in Google Scholar
Fu P.P., Xia Q., Lin G., Chou M.W.: Pyrrolizidine alkaloids-genotoxicity, metabolism enzymes, metabolic activation, and mechanisms. Drug Metab Rev 2004, 36, 1–55.FuP.P.XiaQ.LinG.ChouM.W.Pyrrolizidine alkaloids-genotoxicity, metabolism enzymes, metabolic activation, and mechanisms2004361–5510.1081/DMR-120028426Search in Google Scholar
Griffin C.T., Danaher M., Elliott C.T., Kennedy D.G., Furey A.: Detection of pyrrolizidine alkaloids in commercial honey using liquid chromatography-ion trap mass spectrometry. Food Chem 2013, 136, 1577–1583.GriffinC.T.DanaherM.ElliottC.T.KennedyD.G.FureyA.Detection of pyrrolizidine alkaloids in commercial honey using liquid chromatography-ion trap mass spectrometry20131361577–158310.1016/j.foodchem.2012.02.11223194565Search in Google Scholar
Gottschalk C., Ronczka S., Preiß-Weigert A., Ostertag J., Klaffke H., Schafft H., Lahrssen-Wiederholt M.: Pyrrolizidine alkaloids in natural and experimental grass silages and implications for feed safety. Anim Feed Sci Tech 2015, 207, 253–261.GottschalkC.RonczkaS.Preiß-WeigertA.OstertagJ.KlaffkeH.SchafftH.Lahrssen-WiederholtM.Pyrrolizidine alkaloids in natural and experimental grass silages and implications for feed safety2015207253–26110.1016/j.anifeedsci.2015.06.014Search in Google Scholar
Hoogenboom L.A., Mulder P.P., Zeilmaker M.J., van den Top H.J., Remmelink G.J., Brandon E.F., Klijnstra M., Meijer G.A., Schothorst R., Van Egmond H.P.: Carry-over of pyrrolizidine alkaloids from feed to milk in dairy cows. Food Addit Contam Part A 2011, 28, 359–372.HoogenboomL.A.MulderP.P.ZeilmakerM.J.vanden Top H.J.RemmelinkG.J.BrandonE.F.KlijnstraM.MeijerG.A.SchothorstR.VanEgmond H.P.Carry-over of pyrrolizidine alkaloids from feed to milk in dairy cows201128359–37210.1080/19440049.2010.54752121360378Search in Google Scholar
Huybrechts B., Callebaut A.: Pyrrolizidine alkaloids in food and feed on the Belgian market. Food Addit Contam Part A 2015, 32, 1939–1951.HuybrechtsB.CallebautA.Pyrrolizidine alkaloids in food and feed on the Belgian market2015321939–195110.1080/19440049.2015.108682126373269Search in Google Scholar
Kowalczyk E., Kwiatek K.: Determination of pyrrolizidine alkaloids in selected feed materials with gas chromatography-mass spectrometry. Food Addit Contam Part A 2017, 34, 853–863.KowalczykE.KwiatekK.Determination of pyrrolizidine alkaloids in selected feed materials with gas chromatography-mass spectrometry201734853–86310.1080/19440049.2017.130209928278124Search in Google Scholar
Kowalczyk E., Sieradzki Z., Kwiatek K.: Determination of pyrrolizidine alkaloids in honey with sensitive gas chromatography-mass spectrometry method. Food Anal Methods 2018, 11, 1345–1355.KowalczykE.SieradzkiZ.KwiatekK.Determination of pyrrolizidine alkaloids in honey with sensitive gas chromatography-mass spectrometry method2018111345–135510.1007/s12161-017-1115-8Search in Google Scholar
Martinello M., Cristofoli C., Gallina A., Mutinelli F.: Easy and rapid method for the quantitative determination of pyrrolizidine alkaloids in honey by ultra performance liquid chromatography-mass spectrometry: An evaluation in commercial honey. Food Control 2014, 37, 146–152.MartinelloM.CristofoliC.GallinaA.MutinelliF.Easy and rapid method for the quantitative determination of pyrrolizidine alkaloids in honey by ultra performance liquid chromatography-mass spectrometry: An evaluation in commercial honey201437146–15210.1016/j.foodcont.2013.09.037Search in Google Scholar
Merz K.H., Schrenk D.: Interim relative potency factors for the toxicological risk assessment of pyrrolizidine alkaloids in food and herbal medicines. Toxicol Lett 2016, 263, 44–57.MerzK.H.SchrenkD.Interim relative potency factors for the toxicological risk assessment of pyrrolizidine alkaloids in food and herbal medicines201626344–5710.1016/j.toxlet.2016.05.00227157086Search in Google Scholar
Mulder P.P.J., Beumer B., Oosterink E., de Jong J.: Dutch survey pyrrolizidine alkaloids in animal forage, RIKILT Report No 2009.018, Wegeningen 2009.MulderP.P.J.BeumerB.OosterinkE.de JongJ.Dutch survey pyrrolizidine alkaloids in animal forage, RIKILT Report No 2009.0182009Search in Google Scholar
Mulder P.P.J., López Sánchez P., These A., Preiss-Weigert A., Castellari M.: Occurrence of pyrrolizidine alkaloids in food. 2015, EFSA:EN-859, 1–116.MulderP.P.J.LópezSánchez P.TheseA.Preiss-WeigertA.CastellariM.2015EFSA:EN-8591–11610.2903/sp.efsa.2015.EN-859Search in Google Scholar
Mulder P.P.J., de Witte S.L., Stoopen G.M., van der Meulen J., van Wikselaar P.G., Gruys E., Groot M.J., Hoogenboom R.L: Transfer of pyrrolizidine alkaloids from various herbs to eggs and meat in laying hens. Food Addit Contam Part A 2016, 33, 1826–1839.MulderP.P.J.deWitte S.L.StoopenG.M.vander Meulen J.vanWikselaar P.G.GruysE.GrootM.J.HoogenboomR.LTransfer of pyrrolizidine alkaloids from various herbs to eggs and meat in laying hens2016331826–183910.1080/19440049.2016.124143027762672Search in Google Scholar
SANTE/11945/2015 Guidance document on analytical quality control and method validation procedures for pesticides residues analysis in food and feed. Supersedes SANCO/12571/2013, Implemented by 01/01/2016, 1–42.1–42Search in Google Scholar
Schulz M., Meins J., Diemert S., Zagermann-Muncke P., Goebelm R., Schrenkm D., Schubert-Zsilaveczm M., Abdel-Tawabm M.: Detection of pyrrolizidine alkaloids in German licensed herbal medicinal teas. Phytomedicine 2015, 22, 648–656.SchulzM.MeinsJ.DiemertS.Zagermann-MunckeP.GoebelmR.SchrenkmD. Schubert-Zsilaveczm M., Abdel-Tawabm MDetection of pyrrolizidine alkaloids in German licensed herbal medicinal teas201522648–65610.1016/j.phymed.2015.03.02026055130Search in Google Scholar
Stegelmeier B.L., Edgar J.A., Colegate S.M., Gardner D.R., Schoch T.K., Coulombe R.A., Molyneux R.J.: Pyrrolizidine alkaloid plants, metabolism and toxicity. J Nat Toxins 1999, 8, 95–116.StegelmeierB.L.EdgarJ.A.ColegateS.M.GardnerD.R.SchochT.K.CoulombeR.A.MolyneuxR.J.Pyrrolizidine alkaloid plants, metabolism and toxicity1999895–116Search in Google Scholar