<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jvetres-2018-0005_s_005">
<h3>Introduction</h3>
<p>This study consisted in histopathological and immunohistochemical examinations of the central nervous system of 15 sheep suspected of infection with <italic>Coenurus cerebralis</italic>. The sheep displayed compulsive circling and were submitted for necropsy in 2012–2016.</p></sec>
<sec id="j_jvetres-2018-0005_s_006">
<h3>Material and Methods</h3>
<p>Species identification was made on the basis of the PCR analysis and parasitological examination of the cysts.</p></sec>
<sec id="j_jvetres-2018-0005_s_007">
<h3>Results</h3>
<p><italic>Coenurus cerebralis</italic> cysts were detected only in the cerebral tissue of 13 sheep and in the cerebral and cerebellar tissues of 2 animals. Out of the 33 parasite cysts, most (21.21%) were located in the right and left frontal lobes of the cerebrum. The largest cyst measured 6 × 5 cm and the smallest cyst was 2 × 2 cm in size. The highest and lowest numbers of scolices were 55 and 21, and the number of rostellar hooks ranged between 22 and 30. Histopathological examination revealed the presence of typical parasitic granulomatous inflammatory foci. Immunohistochemical staining showed that most common in the periphery of the parasite cysts were, in descending order by cell number, GFAP, CD163, CD3, and CD79α-positive cells.</p></sec>
<sec id="j_jvetres-2018-0005_s_008">
<h3>Conclusion</h3>
<p>The study confirms the role of cellular defence mechanisms in the pathogenesis of <italic>Coenurus cerebralis</italic> infection in sheep.</p></sec>
</abstract>

Introduction
This study consisted in histopathological and immunohistochemical examinations of the central nervous system of 15 sheep suspected of infection with Coenurus cerebralis. The sheep displayed compulsive circling and were submitted for necropsy in 2012–2016.

Material and Methods
Species identification was made on the basis of the PCR analysis and parasitological examination of the cysts.

Results
Coenurus cerebralis cysts were detected only in the cerebral tissue of 13 sheep and in the cerebral and cerebellar tissues of 2 animals. Out of the 33 parasite cysts, most (21.21%) were located in the right and left frontal lobes of the cerebrum. The largest cyst measured 6 × 5 cm and the smallest cyst was 2 × 2 cm in size. The highest and lowest numbers of scolices were 55 and 21, and the number of rostellar hooks ranged between 22 and 30. Histopathological examination revealed the presence of typical parasitic granulomatous inflammatory foci. Immunohistochemical staining showed that most common in the periphery of the parasite cysts were, in descending order by cell number, GFAP, CD163, CD3, and CD79α-positive cells.

Conclusion
The study confirms the role of cellular defence mechanisms in the pathogenesis of Coenurus cerebralis infection in sheep.

Histopathological, immunohistochemical, and parasitological studies on pathogenesis of <italic>Coenurus cerebralis</italic> in sheep

Department of Anatomy, Faculty of Veterinary Medicine

Department of Genetics, Faculty of Veterinary Medicine

Department of Parasitology, Faculty of Veterinary Medicine

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Histopathological, immunohistochemical, and parasitological studies on pathogenesis of  in sheep

Introduction
This study consisted in histopathological and immunohistochemical examinations of the central nervous system of 15 sheep suspected of infection...

Histopathological, immunohistochemical, and parasitological studies on pathogenesis of Coenurus cerebralis in sheep

Publié en ligne: 30 mars 2018

Pages: 35 - 41

Reçu: 19 déc. 2017

Accepté: 09 mars 2018

DOI: https://doi.org/10.2478/jvetres-2018-0005

Mots clés
sheep, histopathology, PCR, immunohistochemistry

© 2018 Y. Rahsan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Histopathological, immunohistochemical, and parasitological studies on pathogenesis of Coenurus cerebralis in sheep

Publié en ligne: 30 mars 2018

Pages: 35 - 41

Reçu: 19 déc. 2017

Accepté: 09 mars 2018

DOI: https://doi.org/10.2478/jvetres-2018-0005

Mots cléssheep, histopathology, PCR, immunohistochemistry

© 2018 Y. Rahsan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
sheep, histopathology, PCR, immunohistochemistry