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Cenobamate in the management of focal-onset epilepsy in adults – practical considerations for daily practice

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Anderson L.L., Thompson C.H., Hawkins N.A., Nath R.D., Petersohn A.A., Rajamani S. et al.: Antiepileptic activity of preferential inhibitors of persistent sodium current. Epilepsia, 2014, 55: 1274–1283. Anderson L.L. Thompson C.H. Hawkins N.A. Nath R.D. Petersohn A.A. Rajamani S. : Antiepileptic activity of preferential inhibitors of persistent sodium current . Epilepsia , 2014 , 55 : 1274 1283 . Search in Google Scholar

Bell G.S., Mula M., Sander J.W.: Suicidality in people taking antiepileptic drugs: what is the evidence? CNS Drugs, 2009, 23: 281–292. doi:10.2165/00023210-200923040-00002. Bell G.S. Mula M. Sander J.W. : Suicidality in people taking antiepileptic drugs: what is the evidence? CNS Drugs , 2009 , 23 : 281 292. doi:10.2165/00023210-200923040-00002 . Open DOISearch in Google Scholar

Bialer M., Johannessen S.I., Levy R.H., Perucca E., Tomson T., White H.S.: Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI). Epilepsy Res., 2013,103: 2–30. doi: 10.1016/j.eplepsyres.2012.10.001. Bialer M. Johannessen S.I. Levy R.H. Perucca E. Tomson T. White H.S. : Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI) . Epilepsy Res ., 2013,103: 2 30 . doi: 10.1016/j.eplepsyres.2012.10.001 . Open DOISearch in Google Scholar

Bocquet H., Bagot M., Roujeau J.C.: Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS). Semin. Cutan. Med. Surg., 1996, 15, 250–257. Bocquet H. Bagot M. Roujeau J.C. : Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS) . Semin. Cutan. Med. Surg ., 1996 , 15 , 250 257 . Search in Google Scholar

Calle A.M., Aguirre N., Ardila J.C., Cardona Villa R.: DRESS syndrome: A literature review and treatment algorithm. World Allergy Organ J., 2023, 16: 100673. doi: 10.1016/j.wao-jou.2022.100673. Calle A.M. Aguirre N. Ardila J.C. Cardona Villa R. : DRESS syndrome: A literature review and treatment algorithm . World Allergy Organ J ., 2023 , 16 : 100673 . doi: 10.1016/j.wao-jou.2022.100673 . Open DOISearch in Google Scholar

Christensen J., Vestergaard M., Mortensen P.B., Sidenius P., Agerbo E.: Epilepsy and risk of suicide: a population-based case-control study. Lancet Neurol., 2007, 6: 693–698. Christensen J. Vestergaard M. Mortensen P.B. Sidenius P. Agerbo E. : Epilepsy and risk of suicide: a population-based case-control study . Lancet Neurol ., 2007 , 6 : 693 698 . Search in Google Scholar

Cherubini E.: Phasic GABAA-mediated inhibition. In: Noebels J.L., Avoli M., Rogawski M.A. et al. (eds).: Jasper’s Basic Mechanisms of the Epilepsies [Internet]. 4th ed. Bethesda (MD): National Center for Biotechnology Information (US), 2012. Cherubini E. : Phasic GABAA-mediated inhibition . In: Noebels J.L. Avoli M. Rogawski M.A. (eds).: Jasper’s Basic Mechanisms of the Epilepsies [Internet]. 4th ed. Bethesda (MD) : National Center for Biotechnology Information (US) , 2012 . Search in Google Scholar

Chung S.S., French J.A., Kowalski J., Krauss G.L., Lee S.K., Maciejowski M. et al.: Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures. Neurology, 2020, 94: e2311–2322. Chung S.S. French J.A. Kowalski J. Krauss G.L. Lee S.K. Maciejowski M. : Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures . Neurology , 2020 , 94 : e2311 2322 . Search in Google Scholar

Coleman C.I., Limone B., Sobieraj D.M., Lee S., Roberts M.S., Kaur R. et al.: Dosing frequency and medication adherence in chronic disease. J. Manag. Care Pharm., 2012, 18: 527–539. Coleman C.I. Limone B. Sobieraj D.M. Lee S. Roberts M.S. Kaur R. : Dosing frequency and medication adherence in chronic disease . J. Manag. Care Pharm ., 2012 , 18 : 527 539 . Search in Google Scholar

Connor G.: Long-term Cenobamate for Uncontrolled Focal Seizures in Patients Living in a Group Home or With Developmental Disability (P4-1.006). Neurology, 2023, 100 (Suppl. 2): 0191; doi: 10.1212/WNL.0000000000201804 Connor G. : Long-term Cenobamate for Uncontrolled Focal Seizures in Patients Living in a Group Home or With Developmental Disability (P4-1.006) . Neurology , 2023 , 100 ( Suppl. 2 ): 0191 ; doi: 10.1212/WNL.0000000000201804 Open DOISearch in Google Scholar

Elakkary S., Hagemann A., Klimpel D., Bien C.G., Brandt C.: A retrospective non-interventional study evaluating the pharma-cokinetic interactions between cenobamate and clobazam. Epilepsia, 2023, 64: e36– 42. https://doi.org/10.1111/epi.17515 Elakkary S. Hagemann A. Klimpel D. Bien C.G. Brandt C. : A retrospective non-interventional study evaluating the pharma-cokinetic interactions between cenobamate and clobazam . Epilepsia , 2023 , 64 : e36 42 . https://doi.org/10.1111/epi.17515 Search in Google Scholar

Elliott T., Ridley-Pryor T., Gienapp A.J., Wheless J.W.: Initial real-world experience with cenobamate in adolescents and adults: a single center experience. Pediatr. Neurol., 2022, 129: 19–23. Elliott T. Ridley-Pryor T. Gienapp A.J. Wheless J.W. : Initial real-world experience with cenobamate in adolescents and adults: a single center experience . Pediatr. Neurol ., 2022 , 129 : 19 23 . Search in Google Scholar

French J.A., Chung S.S., Krauss G.L., Lee S.K., Maciejowski M., Rosenfeld W.E. et al.: Long-term safety of adjunctive cenobamate in patients with uncontrolled focal seizures: open-label extension of a randomized clinical study. Epilepsia, 2021, 62: 2142–2150. French J.A. Chung S.S. Krauss G.L. Lee S.K. Maciejowski M. Rosenfeld W.E. : Long-term safety of adjunctive cenobamate in patients with uncontrolled focal seizures: open-label extension of a randomized clinical study . Epilepsia , 2021 , 62 : 2142 2150 . Search in Google Scholar

Gaitatzis A., Sisodiya S.M., Sander J.W.: The somatic comorbidity of epilepsy: a weighty but often unrecognized burden. Epilepsia, 2012, 53: 1282–1293. Gaitatzis A. Sisodiya S.M. Sander J.W. : The somatic comorbidity of epilepsy: a weighty but often unrecognized burden . Epilepsia , 2012 , 53 : 1282 1293 . Search in Google Scholar

Greene S., Kwak C., Kamin M., Vernillet L.: The effect of cenobamate on the single dose pharmacokinetics of multiple cytochrome P450 probes using a cocktail approach in healthy subjects [abstract]. Clin. Pharmacol. Ther., 2019, 105 (suppl. 1): S97. Greene S. Kwak C. Kamin M. Vernillet L. : The effect of cenobamate on the single dose pharmacokinetics of multiple cytochrome P450 probes using a cocktail approach in healthy subjects [abstract] . Clin. Pharmacol. Ther ., 2019 , 105 ( suppl. 1 ): S97 . Search in Google Scholar

Guignet M., Campbell A., White H.S.: Cenobamate (XCOPRI): can preclinical and clinical evidence provide insight into its mechanism of action? Epilepsia, 2020, 61: 1–11. Guignet M. Campbell A. White H.S. : Cenobamate (XCOPRI): can preclinical and clinical evidence provide insight into its mechanism of action? Epilepsia , 2020 , 61 : 1 11 . Search in Google Scholar

Hirsch L.J., Weintraub D.B., Buchsbaum R., Spencer H.T., Straka T., Hager M. et al.: Predictors of lamotrigine-associated rash. Epilepsia, 2006, 47: 318–322. doi: 10.1111/j.1528-1167.2006.00423.x Hirsch L.J. Weintraub D.B. Buchsbaum R. Spencer H.T. Straka T. Hager M. : Predictors of lamotrigine-associated rash . Epilepsia , 2006 , 47 : 318 322 . doi: 10.1111/j.1528-1167.2006.00423.x Open DOISearch in Google Scholar

Kanner A.M.: Suicidality in Patients With Epilepsy: Why Should Neurologists Care? Front. Integr. Neurosci., 2022, 16. https://doi.org/10.3389/fnint.2022.898547 Kanner A.M. : Suicidality in Patients With Epilepsy: Why Should Neurologists Care? Front. Integr. Neurosci ., 2022 , 16 . https://doi.org/10.3389/fnint.2022.898547 Search in Google Scholar

Motika P.V., Spencer D.C.: Treatment of epilepsy in the elderly. Curr. Neurol. Neurosci. Rep., 2016, 16: 96. Motika P.V. Spencer D.C. : Treatment of epilepsy in the elderly . Curr. Neurol. Neurosci. Rep ., 2016 , 16 : 96 . Search in Google Scholar

Kim S.H., Lee H., Kim D.W.: Switching antiepileptic drugs to once-daily dosing regimens in epilepsy patients Acta Neurol Scand., 2021, 143: 51–55. doi: 10.1111/ane.13333Epub 2020 Aug 26.PMID: 32762074 Kim S.H. Lee H. Kim D.W. : Switching antiepileptic drugs to once-daily dosing regimens in epilepsy patients Acta Neurol Scand ., 2021 , 143 : 51 55 . doi: 10.1111/ane.13333 Epub 2020 Aug 26.PMID: 32762074 Open DOISearch in Google Scholar

Klein P., Aboumatar S., Brandt C., Dong F., Krauss G.L., Mizne S. et al.: Long-term efficacy and safety from an open-label extension of adjunctive cenobamate in patients with uncontrolled focal seizures. Neurology, 2022, 99: e989– 998. Klein P. Aboumatar S. Brandt C. Dong F. Krauss G.L. Mizne S. : Long-term efficacy and safety from an open-label extension of adjunctive cenobamate in patients with uncontrolled focal seizures . Neurology , 2022 , 99 : e989 998 . Search in Google Scholar

Klein P., Devinsky O., French J., Harden C., Krauss G.L., Mc-Carter R. et al.: Suicidality risk of newer antiseizure medications: a meta-analysis. JAMA Neurol., 2021, 78: 1118–1127. doi:10.1001/jamaneurol.2021.2480. Klein P. Devinsky O. French J. Harden C. Krauss G.L. Mc-Carter R. : Suicidality risk of newer antiseizure medications: a meta-analysis . JAMA Neurol ., 2021 , 78 : 1118 1127. doi:10.1001/jamaneurol.2021.2480 . Open DOISearch in Google Scholar

Krauss G.L., Klein P., Brandt C.: Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial. Lancet Neurol., 2020, 19: 38–48. https://doi.org/10.1016/S1474-4422(19)30399-0 Krauss G.L. Klein P. Brandt C. : Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial . Lancet Neurol ., 2020 , 19 : 38 48 . https://doi.org/10.1016/S1474-4422(19)30399-0 Search in Google Scholar

Latimer D.R., Edinoff A.N., Ruff R.D., Rooney K.C., Penny K.M., Patel S.B. et al.: Cenobamate, a sodium channel inhibitor and positive allosteric modulator of GABAAion channels, for partial onset seizures in adults: A comprehensive review and clinical implications. Neurol. Int., 2021, 13: 252–265. Latimer D.R. Edinoff A.N. Ruff R.D. Rooney K.C. Penny K.M. Patel S.B. : Cenobamate, a sodium channel inhibitor and positive allosteric modulator of GABAAion channels, for partial onset seizures in adults: A comprehensive review and clinical implications . Neurol. Int ., 2021 , 13 : 252 265 . Search in Google Scholar

Löscher W., Schmidt D.: Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs. Epilepsia, 2006, 47: 1253–1284. Löscher W. Schmidt D. : Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs . Epilepsia , 2006 , 47 : 1253 1284 . Search in Google Scholar

Löscher W., Sills G.J., White H.S.: The ups and downs of alkyl-carbamates in epilepsy therapy: How does cenobamate differ? Epilepsia, 2021, 62: 596–614. Löscher W. Sills G.J. White H.S. : The ups and downs of alkyl-carbamates in epilepsy therapy: How does cenobamate differ? Epilepsia , 2021 , 62 : 596 614 . Search in Google Scholar

Lattanzi S., Trinka E., Zaccara G., Striano P., Del Giovane C., Silvestrini M. et al.: Adjunctive cenobamate for focal-onset seizures in adults: a systematic review and meta-analysis. CNS Drugs, 2020, 34: 1105–1120. Lattanzi S. Trinka E. Zaccara G. Striano P. Del Giovane C. Silvestrini M. : Adjunctive cenobamate for focal-onset seizures in adults: a systematic review and meta-analysis . CNS Drugs , 2020 , 34 : 1105 1120 . Search in Google Scholar

Mula M.: Epilepsy and mood disorders. In: The comorbidities of epilepsy. M. Mula (ed.), Elsevier, 2019, pp 299–314. Mula M. : Epilepsy and mood disorders . In: The comorbidities of epilepsy . Mula M. (ed.), Elsevier , 2019 , pp 299 314 . Search in Google Scholar

Mula M., Kanner A.M., Schmitz B., Schachter S.: Antiepileptic drugs and suicidality: an expert consensus statement from the task force Commentary 29 on therapeutic strategies of the ILAE commission on neuropsychobiology. Epilepsia, 2013, 54: 199–203. doi:10.1111/j. 1528-1167.2012.03688.x Mula M. Kanner A.M. Schmitz B. Schachter S. : Antiepileptic drugs and suicidality: an expert consensus statement from the task force Commentary 29 on therapeutic strategies of the ILAE commission on neuropsychobiology . Epilepsia , 2013 , 54 : 199 203. doi: 10.1111/j. 1528-1167.2012.03688.x Open DOISearch in Google Scholar

Nakamura M., Cho J.H., Shin H., Jang I.S.: Effects of ceno-bamate (YKP3089), a newly developed anti-epileptic drug, on voltage-gated sodium channels in rat hippocampal CA3 neurons. Eur. J. Pharmacol., 2019, 855: 175–82. Nakamura M. Cho J.H. Shin H. Jang I.S. : Effects of ceno-bamate (YKP3089), a newly developed anti-epileptic drug, on voltage-gated sodium channels in rat hippocampal CA3 neurons . Eur. J. Pharmacol ., 2019 , 855 : 175 82 . Search in Google Scholar

O’Dwyer R., Stern S., Wade, C., Guggilam A., Rosenfeld W.E.: Safety and Efficacy of Cenobamate for the Treatment of Focal Seizures in Older Patients (P4-1.002) Neurology, 2023, 100 (Suppl. 2): 1897. doi: 10.1212/WNL.0000000000202181 O’Dwyer R. Stern S. Wade C. Guggilam A. Rosenfeld W.E. : Safety and Efficacy of Cenobamate for the Treatment of Focal Seizures in Older Patients (P4-1.002) Neurology , 2023 , 100 ( Suppl. 2 ): 1897 . doi: 10.1212/WNL.0000000000202181 Open DOISearch in Google Scholar

Ontozry. Summary of product characteristics. Accessed July 2023: https://www.ema.europa.eu/en/documents/product-in-formation/ontozry-epar-product-information_en.p Ontozry . Summary of product characteristics . Accessed July 2023 : https://www.ema.europa.eu/en/documents/product-in-formation/ontozry-epar-product-information_en.p Search in Google Scholar

O’Rourke G., O’Brien J.J.: Identifying the barriers to antiepileptic drug adherence among adults with epilepsy. Seizure, 2017, 45: 160–168. O’Rourke G. O’Brien J.J. : Identifying the barriers to antiepileptic drug adherence among adults with epilepsy . Seizure , 2017 , 45 : 160 168 . Search in Google Scholar

Peña-Ceballos J., Moloney P.B., Munteanu T., Doyle M., Colleran N., Liggan B. et al.: Adjunctive cenobamate in highly active and ultra-refractory focal epilepsy: A „real-world” retrospective study. Epilepsia, 2023, 64: 1225–1235. doi: 10.1111/epi.17549. Epub 2023 Feb 27. PMID: 36790345. Peña-Ceballos J. Moloney P.B. Munteanu T. Doyle M. Colleran N. Liggan B. : Adjunctive cenobamate in highly active and ultra-refractory focal epilepsy: A,,real-world” retrospective study . Epilepsia , 2023 , 64 : 1225 1235 . doi: 10.1111/epi.17549 . Epub 2023 Feb 27. PMID: 36790345 . Open DOISearch in Google Scholar

Roberti R., De Caro C., Iannone L.F., Zaccara G., Lattanzi S., Russo E.: Pharmacology of cenobamate: mechanism of action, pharmacokinetics, drug-drug interactions and tolerability. CNS Drugs, 2021, 35: 609–618. doi: 10.1007/s40263-021-00819-88. Roberti R. De Caro C. Iannone L.F. Zaccara G. Lattanzi S. Russo E. : Pharmacology of cenobamate: mechanism of action, pharmacokinetics, drug-drug interactions and tolerability . CNS Drugs , 2021 , 35 : 609 618 . doi: 10.1007/s40263-021-00819-88 . Open DOISearch in Google Scholar

Rosenfeld W.E., Abou-Khalil B., Aboumatar S., Bhatia P., Biton V., Krauss G.L. et al.: Post hoc analysis of a phase 3, multicenter, open-label study of cenobamate for treatment of uncontrolled focal seizures: effects of dose adjustments of concomitant antiseizure medications. Epilepsia, 2021, 62: 3016–3028. Rosenfeld W.E. Abou-Khalil B. Aboumatar S. Bhatia P. Biton V. Krauss G.L. : Post hoc analysis of a phase 3, multicenter, open-label study of cenobamate for treatment of uncontrolled focal seizures: effects of dose adjustments of concomitant antiseizure medications . Epilepsia , 2021 , 62 : 3016 3028 . Search in Google Scholar

Sander J.W., Rosenfeld W.E., Halford J.J., Steinhoff B.J,. Biton V., Toledo M.: Long-term individual retention with cenobamate in adults with focal seizures: pooled data from the clinical development program. Epilepsia, 2022, 63: 139–149. Sander J.W. Rosenfeld W.E. Halford J.J. Steinhoff B. J,. Biton V. Toledo M. : Long-term individual retention with cenobamate in adults with focal seizures: pooled data from the clinical development program . Epilepsia , 2022 , 63 : 139 149 . Search in Google Scholar

Sharma R., Nakamura M., Neupane C., Jeon B.H., Shin H., Melnick S.M. et al.: Positive allosteric modulation of GABAA receptors by a novel antiepileptic drug cenobamate. Eur. J. Pharmacol., 2020, 879: 173117. Sharma R. Nakamura M. Neupane C. Jeon B.H. Shin H. Melnick S.M. : Positive allosteric modulation of GABAA receptors by a novel antiepileptic drug cenobamate . Eur. J. Pharmacol ., 2020 , 879 : 173117 . Search in Google Scholar

Singh A.: Cenobamate for treatment-resistant focal seizures: current evidence and place in therapy. J. Cent. Nerv. Syst. Dis., 2022, 14: 1–5. Singh A. : Cenobamate for treatment-resistant focal seizures: current evidence and place in therapy . J. Cent. Nerv. Syst. Dis ., 2022 , 14 : 1 5 . Search in Google Scholar

Smith M.C., Klein P., Krauss G.L., Rashid S., Seiden L.G., Stern J.M. et al.: Dose adjustment of concomitant antiseizure medications during cenobamate treatment: expert opinion consensus recommendations. Neurol. Ther., 2022, 11: 1705–1720. Smith M.C. Klein P. Krauss G.L. Rashid S. Seiden L.G. Stern J.M. : Dose adjustment of concomitant antiseizure medications during cenobamate treatment: expert opinion consensus recommendations . Neurol. Ther ., 2022 , 11 : 1705 1720 . Search in Google Scholar

Sperling M.R., Abou-Khalil B., Aboumatar S., Bhatia P., Biton V., Klein P. et al.: Efficacy of cenobamate for uncontrolled focal seizures: post hoc analysis of a phase 3, multicenter, open-label study. Epilepsia, 2021, 62: 3005–3015. Sperling M.R. Abou-Khalil B. Aboumatar S. Bhatia P. Biton V. Klein P. : Efficacy of cenobamate for uncontrolled focal seizures: post hoc analysis of a phase 3, multicenter, open-label study . Epilepsia , 2021 , 62 : 3005 3015 . Search in Google Scholar

Sperling M.R., Klein P., Aboumatar S., Gelfand M., Halford J.J., Krauss G.L. et al.: Cenobamate (YKP3089) as adjunctive treatment for uncontrolled focal seizures in a large, phase 3, multicenter, open-label safety study. Epilepsia, 2020, 61:1099–1108 Sperling M.R. Klein P. Aboumatar S. Gelfand M. Halford J.J. Krauss G.L. : Cenobamate (YKP3089) as adjunctive treatment for uncontrolled focal seizures in a large, phase 3, multicenter, open-label safety study . Epilepsia , 2020 , 61 : 1099 1108 Search in Google Scholar

Stafstrom C.E.: Persistent sodium current and its role in epilepsy. Epilepsy Curr., 2007, 7: 15. https://doi.org/10.1111/j.1535-7511.2007.00156.x. Stafstrom C.E. : Persistent sodium current and its role in epilepsy . Epilepsy Curr ., 2007 , 7 : 15 . https://doi.org/10.1111/j.1535-7511.2007.00156.x . Search in Google Scholar

Steinhoff B.J., Sanchez-Alvarez J., Majkowska-Zwolinska B., Maciejowski M., Steinhoff B.J, Rosenfeld W., Serratosa J.M, Brandt C., Klein P., Toledo M., Krauss G.L. et al.: Practical guidance for the management of adults receiving adjunctive cenobamate for the treatment of focal epilepsy – expert opinion. Epilepsy Behav., 2021, 123: 10827 Steinhoff B.J. Sanchez-Alvarez J. Majkowska-Zwolinska B. Maciejowski M. Steinhoff B. J, Rosenfeld W. Serratosa J. M, Brandt C. Klein P. Toledo M. Krauss G.L. : Practical guidance for the management of adults receiving adjunctive cenobamate for the treatment of focal epilepsy – expert opinion . Epilepsy Behav ., 2021 , 123 : 10827 Search in Google Scholar

St Louis E.K.: Truly “rational” polytherapy: maximizing efficacy and minimizing drug interactions, drug load, and adverse effects. Curr. Neuropharmacol., 2009, 7: 96–105. St Louis E.K. : Truly “rational” polytherapy: maximizing efficacy and minimizing drug interactions, drug load, and adverse effects . Curr. Neuropharmacol ., 2009 , 7 : 96 105 . Search in Google Scholar

Vernillet, L.; Greene, S.A.; Kamin, M.: Pharmacokinetics of Cenobamate: Results From Single and Multiple Oral Ascending-Dose Studies in Healthy Subjects. Clin. Pharmacol. Drug Dev., 2020, 9: 428–443. Vernillet L. Greene S.A. Kamin M. : Pharmacokinetics of Cenobamate: Results From Single and Multiple Oral Ascending-Dose Studies in Healthy Subjects . Clin. Pharmacol. Drug Dev ., 2020 , 9 : 428 443 . Search in Google Scholar

Vernillet L., Kamin M.: Drug–drug interactions between cenobamate and other antiepileptic drugs: results from phase I studies with carbamazepine, phenobarbital, phenytoin, and divalproex sodium [abstract]. Clin. Pharmacol. Ther., 2018, 103 (Suppl. S1): 91. Vernillet L. Kamin M. : Drug–drug interactions between cenobamate and other antiepileptic drugs: results from phase I studies with carbamazepine, phenobarbital, phenytoin, and divalproex sodium [abstract] . Clin. Pharmacol. Ther ., 2018 , 103 ( Suppl. S1 ): 91 . Search in Google Scholar

Vernillet L., Greene S.A., Kamin M.: Pharmacokinetics of cenobamate: Results from single and multiple oral ascending-dose studies in healthy subjects. Clin. Pharmacol. Drug Dev., 2020, 4: 428–443. Vernillet L. Greene S.A. Kamin M. : Pharmacokinetics of cenobamate: Results from single and multiple oral ascending-dose studies in healthy subjects . Clin. Pharmacol. Drug Dev ., 2020 , 4 : 428 443 . Search in Google Scholar

Villanueva V., Brandt C.: Efficacy and safety of cenobamate as adjunctive therapy in patients with uncontrolled focal seizures: results from two doubleblind, placebo-controlled, international studies [abstract]. Eur. J. Neurol., 2020, 27 (suppl. 1): 60. Villanueva V. Brandt C. : Efficacy and safety of cenobamate as adjunctive therapy in patients with uncontrolled focal seizures: results from two doubleblind, placebo-controlled, international studies [abstract] . Eur. J. Neurol ., 2020 , 27 ( suppl. 1 ): 60 . Search in Google Scholar

Villanueva V., Santos-Carrasco D., Cabezudo-García P., Gómez-Ibáñez A., Garcés M., Serrano-Castro P. et al.: Real-world safety and effectiveness of cenobamate in patients with focal onset seizures: Outcomes from an Expanded Access Program. Epilepsia Open, 2023 May 7. doi:10.1002/epi4.12757. Villanueva V. Santos-Carrasco D. Cabezudo-García P. Gómez-Ibáñez A. Garcés M. Serrano-Castro P. : Real-world safety and effectiveness of cenobamate in patients with focal onset seizures: Outcomes from an Expanded Access Program . Epilepsia Open , 2023 May 7. doi: 10.1002/epi4.12757 . Open DOISearch in Google Scholar

Wang L., Mei X.-L.: Drug reaction with eosinophilia and systemic symptoms: retrospective analysis of 104 cases over one decade. Chin. Med. J., 2017, 130: 943–949. Wang L. Mei X.-L. : Drug reaction with eosinophilia and systemic symptoms: retrospective analysis of 104 cases over one decade . Chin. Med. J ., 2017 , 130 : 943 949 . Search in Google Scholar

Vossler D.G.: Remarkably high efficacy of cenobamate in adults with focal-onset seizures: A double-blind, randomized, placebo-controlled trial. Epilepsy Curr., 2020, 20: 85–87. Vossler D.G. : Remarkably high efficacy of cenobamate in adults with focal-onset seizures: A double-blind, randomized, placebo-controlled trial . Epilepsy Curr ., 2020 , 20 : 85 87 . Search in Google Scholar

Wolfson A.R., Zhou L., Li Y., Phadke N.A., Chow O.A., Blumenthal K.G.: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome identified in the electronic health record allergy module. J. Allergy Clin. Immuno Pract., 2019, 7: 633–640. Wolfson A.R. Zhou L. Li Y. Phadke N.A. Chow O.A. Blumenthal K.G. : Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome identified in the electronic health record allergy module . J. Allergy Clin. Immuno Pract ., 2019 , 7 : 633 640 . Search in Google Scholar

Zaccara G., Lattanzi S.: Comorbidity between epilepsy and cardiac arrhythmias: implication for treatment. Epilepsy Behav., 2019, 97: 304–312. doi:10.1016/j.yebeh.2019.05.038. Zaccara G. Lattanzi S. : Comorbidity between epilepsy and cardiac arrhythmias: implication for treatment . Epilepsy Behav ., 2019 , 97 : 304 312. doi: 10.1016/j.yebeh.2019.05.038 . Open DOISearch in Google Scholar

Zaccara G., Franciotta D., Perucca E.: Idiosyncratic adverse reactions to antiepileptic drugs. Epilepsia, 2007, 48: 1223–1244. doi:10.1111/j.1528-1167.2007.01041.x. Zaccara G. Franciotta D. Perucca E. : Idiosyncratic adverse reactions to antiepileptic drugs . Epilepsia , 2007 , 48 : 1223 1244. doi: 10.1111/j.1528-1167.2007.01041.x . Open DOISearch in Google Scholar

Zhang L., Wang J., Wang C.: Efficacy and safety of cenobamate in patients with uncontrolled focal seizures: a meta-analysis. Acta Neurol. Scand., 2021, 144: 58–66. Zhang L. Wang J. Wang C. : Efficacy and safety of cenobamate in patients with uncontrolled focal seizures: a meta-analysis . Acta Neurol. Scand ., 2021 , 144 : 58 66 . Search in Google Scholar

Zhang N., Shon J., Kim M.J., Yu C., Zhang L., Huang S.M.: Role of CYP3A in Oral Contraceptives Clearance. Clin. Transl. Sci., 2018, 11: 251–260. Zhang N. Shon J. Kim M.J. Yu C. Zhang L. Huang S.M. : Role of CYP3A in Oral Contraceptives Clearance . Clin. Transl. Sci ., 2018 , 11 : 251 260 . Search in Google Scholar

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