<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Biofilms can form on living or inert surfaces and prevail in natural, industrial, and hospital environments. They are made of bacteria organized in a coordinated functional community. Biofilms do not respond to antibiotic treatment due to multiple mechanisms of tolerance and resistance. If bacteria are coordinated in a biofilm form, they are significantly less susceptible to antibiotics, thus making the therapeutic approach difficult. The possibility of using drugs aimed at inhibiting the formation of biofilms in combination with current antibiotics is a therapeutic approach with a major potential for this type of persistent bacterial infection. This bibliographic study aims to present the main compounds that act by inhibiting or destroying the bacterial biofilm.</p></abstract>

Biofilms can form on living or inert surfaces and prevail in natural, industrial, and hospital environments. They are made of bacteria organized in a coordinated functional community. Biofilms do not respond to antibiotic treatment due to multiple mechanisms of tolerance and resistance. If bacteria are coordinated in a biofilm form, they are significantly less susceptible to antibiotics, thus making the therapeutic approach difficult. The possibility of using drugs aimed at inhibiting the formation of biofilms in combination with current antibiotics is a therapeutic approach with a major potential for this type of persistent bacterial infection. This bibliographic study aims to present the main compounds that act by inhibiting or destroying the bacterial biofilm.

Biofilm Inhibition: Compounds with Antibacterial Effects

Department of Orthopedics and Traumatology

University of Medicine, Pharmacy, Science and Technology

Journal of Interdisciplinary Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Biofilm Inhibition: Compounds with Antibacterial Effects"}

Biofilms can form on living or inert surfaces and prevail in natural, industrial, and hospital environments. They are made of bacteria organized in a...

Biofilm Inhibition: Compounds with Antibacterial Effects

Publié en ligne: 01 févr. 2019

Pages: 234 - 238

Reçu: 31 juil. 2018

Accepté: 17 sept. 2018

DOI: https://doi.org/10.2478/jim-2018-0042

Mots clés
biofilm inhibition, bacterial infection, polysaccharides

© 2018 Andrei-Marian Feier et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Biofilm Inhibition: Compounds with Antibacterial Effects

Publié en ligne: 01 févr. 2019

Pages: 234 - 238

Reçu: 31 juil. 2018

Accepté: 17 sept. 2018

DOI: https://doi.org/10.2478/jim-2018-0042

Mots clésbiofilm inhibition, bacterial infection, polysaccharides

© 2018 Andrei-Marian Feier et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
biofilm inhibition, bacterial infection, polysaccharides