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Measuring bone mineral density is key to determining the risk and presence of osteoporosis, a potential comorbidity for people with haemophilia linked to joint bleeds, inflammation and arthropathy. In countries where DEXA scanning facilities are not widely available, bone turnover markers like b-ALP may be useful in assessing joint health.© Shutterstock
Measuring bone mineral density is key to determining the risk and presence of osteoporosis, a potential comorbidity for people with haemophilia linked to joint bleeds, inflammation and arthropathy. In countries where DEXA scanning facilities are not widely available, bone turnover markers like b-ALP may be useful in assessing joint health.© Shutterstock

Parameters included in Pettersson score [18]

RADIOGRAPHIC PARAMETER FINDING(S) SCORE

Osteoporosis Absent 0
Present 1

Enlarged epiphysis Absent 0
Present 1

Irregular subchondral surface Absent 0
Slight 1
Pronounced 2

Narrowing of joint space Absent 0
< 50% 1
> 50% 2

Subchondral cyst formation Absent 0
One cyst 1
More than one cyst 2

Erosions at joint margins Absent 0
Present 1

Gross incongruence of articulating bone ends (angulation/displacement) Absent 0
Slight 1
Pronounced 2

Joint deformity Absent 0
Slight 1
Pronounced 2

Distribution of joint health scoring and biochemical parameters in different age groups

AGE GROUPS 1 TO 5 YEARS (N=21) >5 TO 10 YEARS (N=67) >10 TO 15 YEARS (N=66) > 15 YEARS (N=166)
No. of joints affected (mean ± SD) 3.81±1.47 4.88±2.25 5.22±2.29 5.56±2.37
HJHS (mean ± SD) 13.71±2.81 14.29±2.39 14.60±2.24 14.26±2.37
Peterson score (mean ± SD) 10.14±1.45 9.76±1.98 10.12±1.6316 10.13±1.81
Calcium (mean ± SD) 9.91±0.50 9.66±0.62 9.77±0.60 9.53±0.58
Low serum calcium (age/sex adjusted) 0% (0/21) 8.9% (6/67) 6.06% (4/66) 21.08% (35/166)
Phosphorus (mean ± SD) 4.42±0.73 4.57±0.65 3.95±0.80 3.56±0.61
Low serum phosphorus (age/sex adjusted) 28.57% (6/21) 17.91% (12/67) 13.63% (9/66) 9.03% (15/166)
Vitamin D3 (ng/dl);(mean ± SD) 12.88±5.24 14.84±7.21 16.35±9.31 17.04±7.57
Low vitamin D3 (<20 ng/dl); (% (n)) 90 % (18/21) 82.09% (55/67) 71.2% (47/66) 71.69%(119/166)
b-ALP (ug/L); (mean ± SD) 116.67±11.2 149.62±23.09 197.95±29.02 42.07±29.691
High b-ALP (age/sex adjusted); (% (n)) 76.19 % (16/21) 86.57 % (58/67) 80.33% (53/66) 94.57 % (157/166)
ALP (U/L); (mean ± SD) 119.42±18.92 103.79±20.73 117.09±24.61 104.75±23.72
eISSN:
2055-3390
Langue:
Anglais
Périodicité:
Volume Open
Sujets de la revue:
Medicine, Basic Medical Science, other, Clinical Medicine, Pharmacy, Pharmacology